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Dosage form: & nbsplozenges
Composition:

1 lozenge contains:

Active substance:

a-tocopherol acetate 50% granulate 200 mg, equivalent to alpha-tocopherol acetate 100 mg.

Excipients: lactose monohydrate, sorbitol, dextrose liquid [dextrose, oligo- and polysaccharides], antifoaming agent, polysorbate-80, glycerol, castor oil, magnesium stearate, silicon dioxide colloidal, anhydrous, dye Opalux As-F-2833 G (dye Crimson Ponce 4R E124 + dye sunset yellow E110), wax emulsion, sucrose.

Description:

Round, biconvex pastilles, covered with a shell of red color.

Inclusions are allowed.

Pharmacotherapeutic group:Vitamin.
Pharmacodynamics:

Fat-soluble vitamin. Stimulates the synthesis of heme and heme-containing enzymes - hemoglobin, myoglobin, cytochromes, catalase, peroxidase. It improves tissue respiration, stimulates the synthesis of proteins (collagen, enzyme, structural and contractile proteins of skeletal and smooth muscles, myocardium), protects against oxidation of vitamin A.

Vitamin E has antioxidant activity, participates in processes of tissue metabolism; prevents hemolysis of erythrocytes, increased permeability and fragility of capillaries, disruption of the function of the seminiferous tubules and testicles,placenta, normalizes reproductive function.

Indications:

- Treatment and prevention of Vitamin E hypovitaminosis

Contraindications:

- Increased individual sensitivity to the components of the drug;

- Acute myocardial infarction;

- Deficiency of lactase or isomaltose enzyme, galactosemia or glucose malabsorption / galactose syndrome, congenital intolerance to fructose;

- Children and adolescents under 18 years.

Carefully:

increased risk of thromboembolism, increased sensitivity to acetylsalicylic acid in history, diabetes mellitus, hypoprothrombinemia (against a background of vitamin K deficiency - may increase with a dose of vitamin E more than 400 ME).

Pregnancy and lactation:

Pregnant women should take vitamin E only on the advice of a doctor. Since vitamin E is excreted into breast milk, therefore, during the period of breastfeeding, taking the drug is not recommended.

Dosing and Administration:

Inside. The lozenge is absorbed in the mouth or swallowed whole, with water. Treatment of hypovitaminosis E: 2 - 3 lozenges per day during or after meals for 20-40 days; after 3-6 months, the course of treatment is repeated.

Prevention of vitamin E vitamin hypovitaminosis: 1 lozenge per day during or after a meal for a month.

Do not take a double dose if you missed the previous dose of the drug.

Side effects:

Allergic reactions and dyspeptic disorders are possible.

In case of appearance, an allergic reaction should stop taking the drug and consult a doctor ....

Overdose:

Symptoms: when taken for a long period of vitamin E at doses of 400-800 units / day - blurred vision, dizziness, headache, nausea, unusual fatigue, diarrhea, gastralgia, asthenia; when taking 800 units / day for a long period - an increased risk of bleeding in patients with hypovitaminosis K, a disorder of thyroid hormone metabolism, a disorder of sexual function, thrombophlebitis, pulmonary embolism, thrombosis, increased activity of creatine phosphokinase, hypercholesterolemia, white hair growth in areas of alopecia with bubble epidermolysis.

Treatment: symptomatic, withdrawal of the drug, the appointment of glucocorticosteroids.
Interaction:

If you are taking other medicines, check with your doctor.Simultaneous reception of large doses of vitamin E and anticoagulants (coumarin and indanedione derivatives) increases the risk of hypoprothrombinemia and bleeding. Avitol is not recommended to be taken concomitantly with iron preparations, vitamin K or anticoagulants.

Pastilles Avitol should not be taken with colestyramine, colestipol, orlistat and mineral oils, since the latter reduce the absorption of vitamin E. It is recommended that you observe a two-hour break between taking these medications.

Enhances the effect of glucocorticosteroids, nonsteroidal anti-inflammatory drugs and antioxidants. .

Increases the effectiveness and toxicity of vitamins A, D and cardiac glycosides. The appointment of vitamin E in high doses can cause vitamin A deficiency in the body.

Increases the effectiveness of antiepileptic drugs in patients with epilepsy (who have increased blood levels of lipid peroxidation products).

Special instructions:

Tocopherols are found in green parts of plants, especially in young sprouts of cereals; large amounts of tocopherols found in vegetable oils (sunflower, cottonseed, corn, peanut, soybean, sea buckthorn).Some of them are found in meat, fat, eggs, milk. It should be borne in mind that in low birth weight babies it is possible to develop hypovitaminosis E with a low permeability of the placenta (fetal blood contains only 20-30% of vitamin E from its concentration in the mother's blood). A diet with an increased content of selenium and sulfur-containing amino acids reduces the need for vitamin E.

Patients with diabetes can take Evitol, but they should consider that each lozenge contains: 0.17 g of lactose, 0.54 g of sucrose and 0.135 g of glucose and 0.119 g of sorbitol.

If you simultaneously take Avitol and other vitamin and vitamin-mineral preparations containing vitamin E, you should consult a doctor.

Pastilles Evitol can be taken with food and drinks.

In 1 lozenge contains 170 mg of lactose, so the drug should not be taken to patients with a deficiency of the enzyme lactase, galactosemia or malabsorption of glucose / galactose.

In 1 lozenge contains 540 mg of sucrose, the drug should not be taken to patients with the following diseases: congenital fructose intolerance, glucose malabsorption / galactose syndrome or isomaltase deficiency.

In 1 lozenge contains 119 mg of sorbitol, the drug should not be taken to patients with congenital intolerance to fructose, tk. this can cause disturbances in the gastrointestinal tract.

Azo dyes E 110 and E 124 may cause an allergic reaction, including bronchospasm. Allergic reactions are often found in people with hypersensitivity to acetylsalicylic acid.

The appointment of Evitol (with a dose of vitamin E more than 400 ME) against a background of vitamin K deficiency increases the risk of hypoprothrombinemia and bleeding.

Effect on the ability to drive transp. cf. and fur:

There is no information that the drug has an effect on the ability to drive vehicles and other mechanisms.


Form release / dosage:

Lozenges 100 mg.

10 lozenges in a blister. For 3 blisters, together with instructions for use, put in a pack of cardboard.

Packaging:packings, cellular, planimetric (3), cardboard
Storage conditions:

Store in a dry place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

2 years.

Do not take the drug after the expiration date.

Terms of leave from pharmacies:Without recipe
Registration number:П N014711 / 01
Date of registration:29.08.2008
The owner of the registration certificate:KRKA, dd, Novo mesto, AOKRKA, dd, Novo mesto, AO
Manufacturer: & nbsp
Representation: & nbspKRKA, dd, Novo mesto, AOKRKA, dd, Novo mesto, AO
Information update date: & nbsp29.08.2008
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