From the nervous system: at the beginning of treatment (especially in elderly patients) - drowsiness, fatigue, dizziness, decreased ability to concentrate, ataxia, disorientation, unsteadiness of gait, slowing of mental and motor reactions, confusion; rarely headache, euphoria, depression, tremor, memory loss, movement coordination disorders (especially at high doses), depression of mood, dystonic extrapyramidal reactions (uncontrolled movements, including eyes), asthenia, myasthenia gravis, dysarthria, epileptic seizures (in patients with epilepsy); extremely rarely - paradoxical reactions (aggressive outbursts, psychomotor agitation, fear, suicidal thoughts, muscle spasm, hallucinations, agitation, irritability, anxiety, insomnia).
On the part of the organs of hematopoiesis: leukopenia, neutropenia, agranulocytosis (chills, hyperthermia, sore throat, excessive fatigue or weakness), anemia, thrombocytopenia.
From the digestive system: dry mouth or salivation, heartburn, nausea, vomiting, decreased appetite, constipation, or diarrhea; violations of liver function, increased activity of "liver" trances and called alkaline phosphatases, jaundice.
From the genitourinary system: urinary incontinence, urinary retention, impaired renal function, decreased or increased libido, dysmenorrhea.
Allergic reactions: skin rash, itching of the skin.
Local reactions: phlebitis or venous thrombosis (redness, swelling, or pain at the injection site).
Other: addiction, drug dependence; lowering blood pressure; rarely - visual impairment (diplopia), weight loss, tachycardia.
With a sharp decrease in dose or discontinuation of reception, there may be a withdrawal syndrome (irritability, nervousness, sleep disturbances, dysphoria, spasm of smooth muscles of the internal organs and skeletal muscles, depersonalization, increased sweating, depression, nausea, vomiting, tremor, perceptual disorders, in tons .h.hyperaemia, paresthesia, photophobia; tachycardia, convulsions, rarely - acute psychosis).