Fenkarol - instructions for use, dose, side effects, contraindications

Active substanceHifenadineHifenadine

Similar drugsTo uncover

Fenkarol®

pills inwards

Olainfarm, AO Latvia

Fenkarol®

solution w / m

Olainfarm, AO Latvia

Fenkarol®

pills inwards

Olainfarm, AO Latvia

Dosage form: & nbspPills

Composition:

active substance: hifenadine hydrochloride 50.0 mg;

Excipients: potato starch 74.0 mg, sucrose 55.0 mg, corn modified starch 20.0 mg, calcium stearate 1.0 mg.

Description:

Round flat-cylindrical tablets of white or almost white color with a bevel.

Pharmacotherapeutic group:Antiallergic agent - H1-histamine receptor blocker.

ATX: & nbsp

R.06.A.X.31 Hifenadine

Pharmacodynamics:Hifenadine - a blocker of H1-histamine receptors, prevents the development and facilitates the course of allergic reactions. Has antiallergic, antiexudative and antipruritic action, preventing the development of allergic inflammation in the tissue. Weaken the effect of histamine, reduce its effect on vascular permeability (reducing permeability, has anti-edematous effect), reduces its bronchospastic effect and spasmogenic effect on the smooth muscles of the intestine, weakens the hypotensive effect of histamine. Hifenadine reduces histamine content in tissues (due to the ability to activate diamino oxidase - an enzyme that inactivates histamine). At course treatment, the antihistamine effect of hifenadine does not decrease.Has a moderate antiserotonin effect, shows a weak M-cholinoblocking activity. Does not have a depressing effect on the central nervous system.

Pharmacokinetics:

45% Hifenadine is rapidly absorbed from the gastrointestinal tract and 30 minutes is found in the tissues of the body. The maximum concentration of active substance in the blood plasma is reached in an hour. Has low lipophilicity, poorly penetrates the blood-brain barrier. The highest content of active substance is found in the liver, slightly less in the lungs and kidneys, the lowest in the brain (less 0,05%, which explains the absence of depressing influence on the central nervous system). Hifenadine is metabolized in the liver. Metabolites are excreted by the kidneys and intestines. The non-absorbed part of the drug is excreted from the intestine.

Indications:

Pollinosis, acute and chronic urticaria, angioedema, allergic rhinitis, dermatosis, including eczema, neurodermatitis, skin itching.

Contraindications:

- Hypersensitivity to any of the components of the drug.

- Pregnancy, lactation.

- Deficiency of sugarase / isomaltase, intolerance to fructose, glucose / galactose malabsorption, since the drug contains sucrose.

- Children under 18 years of age (for a dosage of 50 mg).

Carefully:With caution in diseases of the gastrointestinal tract, liver and kidneys.

Pregnancy and lactation:

The use of the drug during pregnancy is contraindicated. If it is necessary to treat the drug, breastfeeding should be discontinued.

Dosing and Administration:

Inside after eating.

The dose of the drug and the treatment regimen does not change with the indications specified in the instructions. Adults 50 mg 1-4 times a day. The maximum daily dose is 200 mg. The duration of the course of treatment is on average 10-20 days. If necessary, repeat the treatment.

The severity of the allergic reaction and side effects, the individual sensitivity of the patient, can influence the choice of the multiplicity of the drug.

Side effects:

Dryness of the oral mucosa, nausea, vomiting, drowsiness, allergic reactions, headache.

Overdose:

Symptoms: dry mucous membranes, headache, vomiting, abdominal pain and other dyspepsia. Treatment symptomatic. It is necessary to rinse the stomach, take Activated carbon, immediately consult a doctor.

Interaction:

Hyphenadine does not enhance the depressant effect of alcohol and hypnotics on the central nervous system. Possessing weak M-holinoblokiruyuschimi properties, can reduce the motility of the gastrointestinal tract and increase the absorption of slowly absorbed drugs (for example, anticoagulants of indirect action - coumarin derivatives).

Special instructions:

A weak M-holinoblokiruyuschy effect allows you to assign hifenadine patients who are contraindicated with antihistamines that have M-cholinoblocking activity.

Children. Children recommended the use of tablets Fenkarol 25 mg or Fenkarol 10 mg.

Effect on the ability to drive transp. cf. and fur:

Fenkarol is approved for use by individuals whose work requires increased concentration of attention and rapid psychomotor reaction (vehicle management and work with mechanisms), however, it is recommended to determine in advance (by short-term appointment) whether the drug has a sedative effect.

Form release / dosage:Tablets of 50 mg.

Packaging:For 15 tablets in a planar cell packaging made of polyvinylchloride film and aluminum foil. For 1 or 2 contour mesh packages along with the instruction for use are placed in a pack of cardboard.

Storage conditions:

In a dry, protected from light place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

Shelf life:

4 years. Do not use after expiry date.

Terms of leave from pharmacies:Without recipe

Registration number:LP-002704

Date of registration:10.11.2014

The owner of the registration certificate:Olainfarm, AOOlainfarm, AO Latvia

Information update date: & nbsp18.09.2015

Illustrated instructions

Instructions

Fenkarol® (Phencarol®)