Ferrovir - instructions for use, dose, side effects, contraindications

Active substanceDeoxyribonucleate sodium with iron complexDeoxyribonucleate sodium with iron complex

Similar drugsTo uncover

Ferrovir®

solution w / m

FarmPack, LLC Russia

Dosage form: & nbspRAsterol for intramuscular injection.

Composition:

1 ml of the solution contains:

Active substance: sodium deoxyribonucleate 0.015 g, iron oxide chloride 0.000048 g.

Excipient: water for injections.

Description:Transparent liquid of yellow color without foreign inclusions.

Pharmacotherapeutic group:antiviral and immunostimulating agent

ATX: & nbsp

J.05.A.X Other antiviral drugs

Pharmacodynamics:

Ferrovir® is a biologically active substance-extracting milk from sturgeon or salmon fish (purified and standardized complex salt of sodium deoxyribonucleate with iron). The drug of the eyecalls antiviral and immunomodulatory actions, activates antiviral, antifungal and antimicrobial immunities. It exhibits antiviral action in relation to various RNA and DNA-containing viruses. Clinical experience of the drug showed its high activity, good tolerability, lack of toxicity (IFROM₅₀> 4000 μg / ml) and undesirable side effects.

In the treatment of AIDS / HIV infection, a 14-day course of use of the drug Ferrovir ® increases the level of CD4 + lymphocytes in the blood. This increase continues for 1-1,5 months after the end of the course of treatment.Simultaneously, the viral load in the body decreases, which is expressed in a decrease in the concentration of HIV RNA in comparison with the baseline level.

With recurrent herpetic infection, the severity and duration of relapse is reduced, there is a rapid and long-term remission after a 10-day course of treatment.

The use of Ferrovir ® in the complex treatment of patients with chronic hepatitis C contributes to improving the tolerability of treatment (reducing dizziness, nausea, etc.), reducing the replicative activity of all genotypes of the virus HCV, transfer of the process to a latent phase with the restoration of liver cells and the absence of viral replication. The drug is characterized by a high degree of activity in the joint presence of primary and opportunistic viruses.

Pharmacokinetics:

With intramuscular administration of the recommended dose, the drug is rapidly absorbed and distributed in organs and tissues involving the endolymphatic transport pathway; has a high tropism to the organs of the hematopoietic system; takes an active part in cellular metabolism, integrating into cellular structures.In the course of daily course use has the property of cumulating in organs and tissues.

The time to reach the maximum concentration for a single dose is 0.5 hours, after which the concentration of the drug in the blood begins to decrease, due to its distribution in organs and tissues. With repeated administration of the drug every 24 hours for 4 days, its greatest accumulation in the spleen, lymph nodes and bone marrow is observed. After the 5th administration, the concentration of the drug in subsequent administration in all organs and tissues does not increase, its gradual decrease is observed.

Metabolism and excretion

The drug is excreted from the body (in the form of metabolites), partially intestinal and mostly kidney. The average retention time in organs and tissues is 72 hours. Half-life is 36 hours.

Indications:Ferrovir ® is used in combination therapy of HIV-infected patients and AIDS patients, HIV-infected patients with hepatitis C, HIV-infected patients with recurrent herpetic infection.

In the treatment of patients with tick-borne encephalitis, hepatitis C, herpes.

Contraindications:

Individual intolerance.

Pregnancy and lactation period, children's age.

Dosing and Administration:

In the treatment of HIV infection or AIDS adults, the drug is administered intramuscularly: 5 ml (15 mg / ml) solution for intramuscular administration (75 mg in terms of dry matter) 2 times a day, for 14 days. If necessary, depending on the dynamics of the number of T4-lymphocytes and the level of HIV-1 RNA in peripheral blood, after 1-1,5 months a second course of therapy is prescribed.

In the treatment of herpes - 5 ml (15 mg / ml) solution for intramuscular injection 2 times a day, for 10 days.

In the treatment of hepatitis C Ferrovir® is administered intramuscularly 2 times a day for 5 ml (15 mg / ml) solution for intramuscular injection for 14 days. In the next 14 days, the drug is administered at the same daily dose every other day.

In tick-borne encephalitis the drug is administered 2 times a day for 5 ml (15 mg / ml) solution for intramuscular injection for 5-10 days.

When using an intramuscular solution of 2 ml, recalculate before reaching the exchange rate of 750-2100 mg.

Side effects:Perhaps a short-term increase in body temperature (up to 38 ° C), hyperemia and moderate soreness at the injection site.

Overdose:

There were no negative effects from an overdose.

Interaction:Havemeasures the effect of anticoagulants.

In complex therapy reduces the toxicity and negative impact of the drugs (antibacterial, antiviral, antifungal and cytotoxic drugs) using cytoprotective properties and optimizing the metabolic processes of the hepatocyte.

Special instructions:

To reduce morbidity Ferrovir® administered intramuscularly slowly, within 1-2 min.

The solution for injection should be fully used immediately after opening the bottle, do not store open bottles.

Intravenous administration of the drug is not allowed!

Effect on the ability to drive transp. cf. and fur:

Effect of the drug on the ability to drive vehicles or moving mechanisms are not noted.

Form release / dosage:RAsterol for intramuscular injection, 15 mg / ml.

Packaging:

ATabout bottles of 2 ml, 5 ml of colorless or brown glass.

Original packaging by 5 ml glass bottles, sealed with a rubber stopper and rolled with an aluminum cap with detachable plastic packing in pallets of blisters in cardboard pack No. 5,or 2 ml glass bottles, sealed with a rubber stopper and rolled with an aluminum cap with a detachable plastic nozzle in pallets of blisters in cardboard pack No. 10.

Storage conditions:

In the dark place at a temperature of +4 to +20 ° C.

Keep out of the reach of children.

Shelf life:

5 years.

Do not use the product after the expiry date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:P N000630 / 01

Date of registration:05.08.2011 / 19.07.2016

Expiration Date:Unlimited

The owner of the registration certificate:FarmPack, LLCFarmPack, LLC Russia

Manufacturer: & nbsp

Immunnoleks FZ, LLC Russia

Representation: & nbspImmunnoleks FZ, LLCImmunnoleks FZ, LLCRussia

Information update date: & nbsp07.01.2017

Illustrated instructions

Instructions

Ferrovir® (Ferrovir®)