Adverse reactions are listed according to the following gradation frequency of their occurrence: very often (> 10%); often (> 1% to <10%); infrequently (> 0.1% to <1%).
From the hematopoiesis: often - anemia *; in isolated cases - febrile neutropenia.
On the part of the digestive system: often - diarrhea, nausea, increased activity of "liver" transaminases; infrequent - constipation, vomiting, decreased appetite, abdominal pain, discomfort in the abdominal cavity, dry mouth, increased bilirubin concentration, increased activity of alkaline phosphatase.
From the cardiovascular system: very often - "tides" *; infrequent - arrhythmias (including atrial fibrillation), palpitations, atrioventricular block of degree I, increased interval Q-T*, increased blood pressure, vasovagal syncope, varicose veins; in isolated cases - myocardial infarction, acute heart failure.
From the respiratory system: infrequently - shortness of breath, cough.
From the nervous system and psyche: often - dizziness, headache, insomnia; infrequently - hypostasis, irritability, decreased intellectual activity, depression, ringing in the ears, decreased libido *.
From the urinary system: very often - an increase in the concentration of urea in the blood serum; often - increased serum creatinine concentration; infrequent - frequent urination, mandatory urination, dysuria, nocturia, urinary incontinence, renal insufficiency.
From the skin and skin appendages: often - increased sweating (including night sweats) *, skin rash; infrequently - urticaria rash, alopecia, skin itch, erythema, hyperpigmentation of the skin, softening of the nail plates.
From the musculoskeletal system: often - musculoskeletal pain; infrequently - osteoporosis / osteopenia, muscle weakness, muscle cramps, swelling and joint stiffness.
On the part of the reproductive system: often - gynecomastia *, testicular atrophy *, erectile dysfunction *; infrequent - soreness of the testicles, tenderness of the mammary glands, pain in the pelvic region, irritation of the genitals, frustration of the ejaculation.
From the immune system: infrequently - hypersensitivity.
Local reactions: very often - redness and pain at the injection site; often - swelling, condensation in the area of injection.
Metabolic disorders: often - hyperkalemia; infrequently - hyperglycemia, diabetes mellitus, increased cholesterol concentration, changes in calcium concentration in the blood serum.
Other: often - fever, chills, fatigue *, flu-like syndrome, weight gain *; infrequent - a feeling of malaise, peripheral edema, weight loss, decreased visual acuity.
* - reactions associated with the suppression of testosterone production, which are of a temporary nature and, as a rule, do not require withdrawal of the drug.