When fluoxetine is used, as in the case of the use of drugs of the group of selective serotonin reuptake inhibitors, the following undesirable effects are noted.
From the side of the cardiovascular system
Often (> 1% - <10%): atrial flutter, hot flashes (hot flushes).
Infrequently (> 0,1% - <1%): hypotension.
Rarely (<0.1%): vasculitis, vasolilation.
From the side of the digestive system Very often (> 10%) diarrhea, nausea.
Often (> 1% - <10%): dry mouth, indigestion, vomiting.
Infrequently (> 0.1% - <1%): dysphagia, a taste perversion.
Rarely (<0.1%): pain along the esophagus.
From the hepatobiliary system Rarely (<0.1%): idiosyncratic hepatitis.
From the immune system:
Very rarely (<0.1%): anaphylactic reactions, serum sickness.
Metabolic and nutritional disorders
Often (> 1% - <10%): anorexia (including weight loss) of the body.
From the musculoskeletal system infrequently (> 0.1% - <1%): muscle twitching.
From the side of the central nervous system
Very often (> 10%): headache.
Often (> 1% - <10%): attention disturbance, dizziness, lethargy, drowsiness (including hypertonia, sedation), tremor.
Infrequently (> 0.1% - <1%): psychomotor agitation, hyperactivity, ataxia, impaired coordination, bruxism, dyskinesia, myoclonus.
Rarely (<0.1%): bucco-glossal syndrome, seizures, serotonin syndrome.
Mental disorders
Very often (> 10%): insomnia (including early morning awakening, primary and secondary insomnia).
Often (> 1% - <10%): unusual dreams (including nightmares), nervousness, tension, decreased libido (including lack of libido), euphoria, sleep disorder.
Infrequently (> 0,1% - <1%): depersonalization, hypertension, violation of orgasm (including anorgasmia), impaired thinking.
Rarely (<0.1%): manic disorders.
From the skin
Often (> 1% - <10%): hyperhidrosis, itchy skin, polymorphous skin rash, urticaria. Infrequently ((> 0,1% - <1%): ecchymosis, tendency to bruising, alopecia, cold sweat.
Rarely (<0.1%): angioedema, photosensitivity reactions.
From the sense organs
Often (> 1% - <10%): blurred vision.
Infrequently ((> 0,1% - <1%): mydriasis.
From the genitourinary system
Often (> 1% - <10%): frequent urination (including pollakiuria), ejaculation disorder (including lack of ejaculation, dysfunctional ejaculation, early ejaculation, ejaculation delay, retrograde ejaculation), erectile dysfunction, gynecological bleeding (including bleeding from the cervix, dysfunctional uterine bleeding, bleeding from the genital tract, menometrorrhagia, menorrhagia, metrorrhagia, polymenorrhoea, postmenopausal bleeding, uterine bleeding, vaginal bleeding).
Infrequently (> 0.1% - <1%): dysuria.
Rarely (<0.1%): sexual dysfunction, priapism.
Post-marketing messages
From the side of the endocrine system, cases of an antidiuretic hormone deficiency were noted.
These side effects often occur at the beginning of fluoxetine therapy or with an increase in the dose of the drug.