Frequency of development of side effects is stated in accordance with the followinggradation: most often (10 % and higher), less often (from 1 to 10%), rarely (less than 1%).
When the drug is used in monotherapy
Most often: gynecomastia and / or pain in the mammary gland, sometimes followed by galactorrhea. These phenomena disappear after abolition of ledose reduction.
Less often: diarrhea, nausea, vomiting, increased appetite, insomnia, increased fatigue, transient liver dysfunction.
Rarely: hepatitis or jaundice (including cholestatic), liver necrosis, hepatic encephalopathy, increased transaminase activity (these side effects are usually reversible after discontinuation of therapy, but there have been reports of fatal outcomes due to severe hepatic insufficiency with flutamide therapy); subcutaneous hemorrhages, shingles, skin itching, lupus-like syndrome; anorexia, heartburn, constipation, diarrhea; decreased libido, headache, hot flashes (fever, sweating), increased blood pressure, dizziness, weakness, visual acuity, thirst, chest pain, swelling (fingers, feet, shins), anxiety , depression and thrombocytopenia. With prolonged treatment, suppression of spermatogenesis was noted.Some cases of development of hemolytic anemia, macrocytic anemia, methemoglobinemia, reaction of increased photosensitivity (including erythema, ulceration of the skin, bullous rash, epidermal necrolysis) have been noted. Sometimes, patients experience a change in the color of urine from amber to yellow-green.
When treated in combination with GnRH agonists
Most often: "hot flashes" (fever, increased sweating), decreased libido, impotence, diarrhea, nausea, vomiting. The incidence of these side effects, with the exception of diarrhea (more pronounced when used in conjunction with flutamins - home), is the same as in monotherapy with agonists G nRG.
Less often: gynecomastia, anemia, leukopenia, thrombocytopenia, lack of appetite, swelling, symptoms of neuromuscular disorders, difficulty urinating, increased blood pressure and side effects from the central nervous system (drowsiness, depressionthis, confusion, anxiety, neurosis).
Rarely: impaired respiration, hepaticinsufficiency, hepatitis, cholestattic jaundice, liver necrosis, hepatic encephalopathy, increasedphotosensitivity, methemoglobinemia.