From the central nervous system: headache, dizziness, depressed mood.
From the gastrointestinal tract, liver, pancreas: nausea, vomiting, diarrhea, oral lesions (stomatitis, gingivitis, glossitis, etc.), gastritis, cholangitis, hepatitis, insufficiency of B vitamins (due to oppression of the intestinal microflora).
From the urinary system: urolithiasis disease.
From the respiratory system: eosinophilic pneumonia.
From the side of the cardiovascular system: myocarditis, cyanosis.
On the part of the blood system: in rare cases - leukopenia, thrombocytopenia, agranulocytosis, hemolysis of erythrocytes. With prolonged use, anemia may occur due to a deficiency of pantothenic and pteroylglutaric acids produced by microbial cells.
Allergic and toxic-allergic reactions: drug allergy, incl. cutaneous manifestations of drug allergy in the form of a variety of rashes, up to nodular and multiforme exudative erythema, in some cases - epidermal necrolysis (Lyell's syndrome). In some cases, there is an allergic edema of the lips and face, nodular periarteritis.