Phthivazide (Ftivazide)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substancePhthivazidePhthivazide
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  • Phthivazide
    pills inwards 
    FARMASINTEZ, JSC (Irkutsk)     Russia
  • Phthivazide
    pills inwards 
    AVEKSIMA, JSC     Russia
  • Phthivazide
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    ROSFARM, LLC     Russia
  • Phthivazide
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    UZOLE-SIBERIAN CHEMICAL PLANT, OJSC     Russia
  • Phtivazide MS
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    MEDISORB, CJSC     Russia
    • Dosage form: & nbsppills
    Composition:

    active substance: 0.3 g or 0.5 g of ftivazide;

    Excipients: potato starch, calcium stearate, low molecular weight polyvinylpyrrolidone.

    Description:

    tablets of light yellow or yellow color, flat-cylindrical shape with a facet and a risk with a weak smell of vanillin.

    Pharmacotherapeutic group:Anti-tuberculosis drug.
    ATX: & nbsp

    J.04.A.C   Derivatives of isonicotinic acid hydrazide

    Pharmacodynamics:

    Anti-tuberculosis drug, derivative of hydrazide isonicotinic acid (GINC). Has a pronounced selective activity against mycobacteria tuberculosis. It causes damage to the membrane of mycobacteria, inhibits metabolic and oxidative processes, inhibits the synthesis of nucleic acids, acts on mycobacteria both inside the cell and outside it.

    Pharmacokinetics:

    Absorption is high. TSam - 1-2 hours. Connection with plasma proteins - less than 10%. It penetrates the placental barrier and into the mother's milk.Metabolised in the liver with the formation of the main metabolite - GINK, which later undergoes hydrolysis and acetylation. T1/2 - 2-5 hours. It is excreted by the kidneys (95% in the form of metabolites), a small amount - by the intestine.

    Indications:

    Treatment of active tuberculosis of all forms and localizations in adults and children.

    Contraindications:

    Hypersensitivity, angina pectoris, chronic heart failure II-III st. (including decompensated heart defects), epilepsy, organic lesions of the central nervous system, liver and / or kidney disease (non-tuberculosis), chronic renal failure, alcoholism, pregnancy, lactation. Children under 3 years (for this dosage form).

    Dosing and Administration:

    Inside. Adults - 500 mg 2-3 times / day. Higher doses for adults: single -1 g, daily - 2 g.

    Children - at the rate of 30-40 mg / kg / day (maximum daily dose - 1.5 g) in 3 divided doses. In case of tuberculous lupus - 250-300 mg 3-4 times / day. On the course - 40-60 g. If necessary, the course of treatment is repeated 2-3 times with a monthly break.

    Side effects:

    Headache, dizziness, nausea, vomiting, dry mouth, decreased appetite, pain in the heart and in the epigastrium, skin allergic reactions, arthralgia.Euphoria, worsening of sleep, increased fatigue, depressive states, in rare cases - the development of psychosis, memory disorders, peripheral neuritis and optic neuritis, drug hepatitis, in men - gynecomastia, in women - menorrhagia. In patients with epilepsy, convulsive seizures may increase. Adverse events occur with a reduced dose or a temporary break in taking the drug.

    Interaction:

    Strengthens the side effects of paracetamol, alcohol, benzodiazepines, carbamazepine, the effect of anticoagulants and antiplatelet agents, decreases the mineralocorticoids and glucocorticoids. Enhances the effect of hepatotoxic drugs. Simultaneous reception of antacids slows the absorption of ftyvazid.

    Special instructions:

    During the period of treatment, periodic examination of the fundus is necessary. To prevent the development of neuritis, concomitantly with the drug, vitamins B1 and B6 . The drug can be used to treat patients with increased sensitivity to isoniazid. The maximum efficiency is manifested with "fresh", acute processes.

    Form release / dosage:

    Tablets of 300 mg or 500 mg.


    Packaging:

    10 contour packs in a pack. For 10 tablets in a planar cell package. For 50 or 100 tablets in a can of polyethylene.

    For 10 contour packs with instructions for use in a pack of cardboard. Bank with instructions for use in a pack of cardboard.

    Storage conditions:

    List B.

    In a dry place, protected from light, at a temperature of no higher than 25 0 ะก. Store in a place inaccessible to children.

    Shelf life:

    4 years.

    Do not use the product after the expiry date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:P N000592 / 01
    Date of registration:31.08.2007
    The owner of the registration certificate:ROSFARM, LLC ROSFARM, LLC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp05.11.2015
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