"Fluodeoxyglucose, 18F" in the form of a sterile solution is injected intravenously.
From the pharmacokinetic data on the time of maximum accumulation of fluorodezox-siglucose, 18F in the organs and the rate of its removal, it follows that the optimal time for the onset of myocardial and brain scans is 35-40 minutes after drug administration, while the conditions for the study of the brain and myocardium persist within 60-70 minutes after its administration.
In the "whole body" study, the optimal time to start scanning is 90-120 minutes after intravenous RFP. Optimal conditions for the study of the whole body in cancer patients are preserved within 4 hours after the administration of RFP.
The diagnostic dose of RFP for conducting positron emission tomography of the brain and myocardium is 100-120 MBq per 1 m2 of the body surface of the patient, with a typical use of 150-240 MBq per study. The surface of the body is calculated from the nomogram based on the weight and height of the patient. The drug is injected intravenously in a volume of 0.5-2.0 ml.
With a PET whole-body examination, the diagnostic dose of the drug is 220 MBq per 1 m2 of the body surface of the patient; as a rule, use 300-550 MBq per study.The drug is administered intravenously slowly in a volume of 5.0-10.0 ml. Usually, before administration, the dose of "Fluodeoxyglucose, 18F" required for a given patient is diluted with sterile saline, bringing the contents of the syringe to 5.0-10.0 ml, which is necessary to accurately dose the injected activity and reduce RFP uptake in the brain and myocardium. The radioactivity of the drug remaining in the syringe after the administration should be measured to clarify the dose administered.
Radiation loads
Dose coefficients for calculation of effective radiation doses for patients using the drug "fluorodeoxyglucose, 18F" (MU 2.6.1.1798-03).
Compound | Dose factors, mSv / MBq |
| Adults | 1-2 years | 3-7 years | 8-12 years old | 13-15 years old |
Fluorodeoxyglucose, F | 0,019 | 0,095 | 0,05 | 0,036 | 0,025 |
Dose factor for intravenous administration of "fluorodeoxyglucose,18F " in adults is 19x10'3 mSv / MBq. When the diagnostic dose of the drug is administered (from 150 to 550 MBq), the effective dose is 2.85-10.45 mSv.
Absorbed doses of radiation in adult patients with intravenous administration of the drug "fluorodeoxyglucose,18P "by the authorities.
Organs and tissues | The absorbed dose of 10 3 mGy / MBq |
Red marrow | 11 |
Skeleton | 14 |
Eggs | 14 |
Ovaries | 15 |
Liver | 16 |
Lungs | 16 |
A heart | 17 |
Kidneys | 19 |
Stomach | 25 |
Pancreas | 27 |
Spleen | 39 |
Brain | 43 |
Bladder | 114 |