Gastal® (Gastal®)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbsptablets for resorption [mint, cherry]
Composition:1 tablet contains:

active substances: aluminum hydroxide-magnesium carbonate gel 450.0 mg, magnesium hydroxide 300.0 mg;

Excipients: lactose monohydrate 111.5 / 112.0 / 112.0 mg, mannitol 110.0 / 112.0 / 112.0 mg, pregelatinized starch 32.0 / 32.0 / 32.0 mg, silicon dioxide colloid 2, 0 / 2.0 / 2.0 mg, croscarmellose sodium (type A) 50.0 / 50.0 / 50.0 mg, aspartame 2.5 (2.0 / 2.0 mg, magnesium stearate 6.0 / 6,0 / 6,0 mg, mint flavor 11890-71 (mint tablets) 6.0 mg or cherry flavor E 9407963 (cherry tablets) 4.0 mg or orange flavoring 1016042 (orange tablets) 4.0 mg.

Description:

Round flat tablets white or almost white with a smooth surface and bevel.

Pharmacotherapeutic group:Antacid agent
ATX: & nbsp
  • Antacids in combination with other drugs
    • Pharmacodynamics:

    The drug Gastal® is a buffer antacid that eliminates the increased acidity and associated abnormalities of the stomach.

    The aluminum hydroxide-magnesium carbonate gel acts as an antacid buffer, reducing the increased acidity of the gastric juice to a physiological level (pH 3-5), thereby promoting normal digestion without increasing secretory activity. Magnesium carbonate quickly has a neutralizing effect for a long time, enhancing the antacid effect.

    The antacid effect of the drug begins immediately after taking the pill, the duration is about 2 hours. One Gastal® tablet neutralizes 21.5 mmol of hydrochloric acid. In the recommended dose, the drug raises the pH to 3-5, thus eliminating free hydrochloric acid. Gastal® inhibits the action of pepsin, lysolecithin, and bile acids.

    It has been proved that antacids containing aluminum hydroxide strengthen protective and regenerative processes in the gastric mucosa.

    The cytoprotective effect of aluminum ions includes: increased secretion of mucin and sodium hydrogencarbonate activation of prostaglandin E2 and NO, the accumulation of epidermal growth factor at the site of damage to the mucous membrane, increasing the concentration of phospholipids in the walls of the stomach. The mechanism of this action is not fully understood.
    Pharmacokinetics:

    The drug Gastal® does not have a systemic effect in patients with normal renal function.

    After interaction with hydrochloric acid of gastric juice of aluminum, the hydroxide reacts with phosphates and carbonates in the alkaline environment of the intestine and is excreted by the intestines in the form of insoluble salts.

    Magnesium hydroxide reacts with hydrochloric acid in gastric juice to form magnesium chloride, which has an osmotic soft laxative effect that neutralizes the fixing action of aluminum hydroxide in the small intestine. Magnesium ions are excreted by the intestine in the form of insoluble carbonate.
    Indications:

    Symptomatic treatment of hyperacid conditions (including those accompanied by heartburn), associated with peptic ulcer of the stomach and duodenum, gastritis, reflux esophagitis.

    Contraindications:

    - Hypersensitivity to salts of aluminum, magnesium or other components of the drug;

    - severe renal insufficiency;

    - Children's age is less than 6 years.

    Carefully:

    - Chronic renal insufficiency;

    - Children age over 6 years.

    Pregnancy and lactation:The drug Gastal® does not have a systemic effect, it does not excrete with breast milk. Nevertheless, the appointment of the drug during pregnancy and lactation is possible only under the supervision of a doctor.
    Dosing and Administration:

    Adults

    The drug is recommended to take 1-2 tablets 4-6 times a day about an hour after meals and at bedtime, but not more than 8 tablets per day.

    Duration of reception should not exceed 2 weeks.

    Similar doses are recommended for the treatment of heartburn regardless of food intake.

    Children from 6 to 12 years old

    The drug is recommended to take in a dose that is half of the recommended dose for adults.

    Tablets should be taken orally, gradually dissolving in the mouth.
    Side effects:

    When using the drug at recommended doses, adverse side effects are rare: nausea, constipation, diarrhea, changes in taste.

    In exceptional cases, allergic reactions occur.

    Overdose:

    Symptoms of acute overdose have not been documented. Perhaps the development of more pronounced adverse reactions from the gastrointestinal tract (constipation, diarrhea).

    Symptomatic treatment is indicated.

    Interaction:The drug Gastal® enhances the activity of levodopa and nalidixic acid.
    The activity of tetracyclines, quinolones, acetylsalicylic acid, isoniazid, naproxen, iron preparations, indomethacin, aminazine, β-blockers, diflunizal, H2-gistaminovogo blockers, vitamins A, D, E, K, indirect anticoagulants, barbiturates and cardiac glycosides is reduced.In this regard, the above drugs should be taken one hour before or 2 hours after taking Gastal®.
    M-holinoblokatory, slowing the motor motility of the stomach, lengthen the action of the drug.
    Special instructions:
    Reduced doses and a shorter treatment period are indicated for patients with reduced weight and for children.
    Patients with reduced renal function should avoid prolonged use of the drug in elevated doses.
    Continuous intake of more than 2 weeks is possible only after consulting a doctor.
    Effect on the ability to drive transp. cf. and fur:Does not affect.
    Form release / dosage:Tablets for resorption [mint, cherry and orange].
    Packaging:
    For 6 tablets in a blister of PVC / PVDC and aluminum foil.
    For 2, 4 or 8 blisters together with instructions for use in a cardboard box.
    Storage conditions:

    At a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    3 years.

    Do not use after the expiry date printed on the package.

    Terms of leave from pharmacies:Without recipe
    Registration number:LS-002166
    Date of registration:12.05.2011 / 04.07.2016
    Expiration Date:Unlimited
    The owner of the registration certificate:Pliva of Hrvatska dooPliva of Hrvatska doo Croatia
    Manufacturer: & nbsp
    Representation: & nbspTeva Teva Israel
    Information update date: & nbsp02.03.2016
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