Included in the formulation
АТХ:D.07.C.B.04 Dexamethasone in combination with antibiotics
Pharmacodynamics:Combination drug for topical application in ophthalmology. Has anti-allergic, anti-inflammatory and antibacterial action.
Gentamicin
Antibiotic from the group of aminoglycosides. It binds to the 30S subunit of the ribosome of the bacterial cell and disrupts the movement of the ribosome along the RNA strands. It also changes the processes of reading the code of the RhK, which leads to the synthesis of functionally inactive proteins. Is able to disrupt the permeability of the cytoplasmic membrane of microorganisms. Has a bactericidal action type in a relationship Neisseria gonorrhoeae, including strains producing penicillinase.
Dexamethasone
Has anti-inflammatory, antipruritic, anti-allergic, decongestant and vasoconstrictive. It prevents the accumulation of neutrophils on the skin, reducing inflammatory exudate and production of lymphokines, inhibits the migration of macrophages, reduces the processes of infiltration and granulation.
By inhibiting the activity of phospholipase A2 and reducing the release of arachidonic acid from the phospholipids of cell membranes, the production of leukotrienes andprostaglandins. Reduces the main substance of the connective tissue, weakening the exudative and proliferative processes in the skin. Inhibits cellular kinins, which have proteolytic activity.
Pharmacokinetics:Means for topical application, practically not absorbed into the bloodstream and does not have a systemic effect.
Indications:
It is used to treat infections of the anterior chamber of the eye: conjunctivitis, keratitis, blepharitis, meibomite (barley); with allergic eye diseases with bacterial superinfections. Used for the prevention and treatment of inflammatory complications after operations in ophthalmology.
VII.H00-H06.H00.0 Gordoleum and other deep inflammation of the eyelids
VII.H00-H06.H01.0 Blepharitis
VII.H00-H06.H04.3 Acute and unspecified inflammation of lacrimal ducts
VII.H00-H06.H04.4 Chronic inflammation of lacrimal ducts
VII.H10-H13.H10.1 Acute atopic conjunctivitis
VII.H10-H13.H10.2 Other acute conjunctivitis
VII.H10-H13.H10.4 Chronic conjunctivitis
VII.H10-H13.H10.5 Blepharoconjunctivitis
VII.H15-H22.H16 Keratite
XXI.Z20-Z29.Z29.8 Other specified preventive measures
XIX.T80-T88.T88 Other complications of surgical and therapeutic interventions, not elsewhere classified
XXI.Z100.Z100 * CLASS XXII Surgical Practice
Contraindications:Herpetic keratitis, zakratougolnaya and open angle glaucoma, ulcerous lesions and injuries of the cornea, tuberculosis and fungal infections of the eyes, individual intolerance, children under 18 years.
Carefully:Wearing contact lenses.
Pregnancy and lactation:
Recommendations for FDA - Category B. Contraindicated in the first trimester of pregnancy. Possible use in the II-III trimester of pregnancy in the event that the intended benefit for the mother exceeds the possible risk to the fetus.
Dosing and Administration:Eye drops in the conjunctival sac 4-6 times a day.
A strip of ointment up to 1 cm is placed in the conjunctival sac 2-3 times a day.
Duration of treatment is 2-3 weeks.
Side effects:Burning in the eye immediately after applying the drug, allergic reactions.
Overdose:
Cases of overdose are not described.
Treatment is symptomatic.
Interaction:Simultaneous use of atropine and other cholinergic drugs increases the risk of increased intraocular pressure.
In topical application with heparin, amphotericin B, cloxacillin, sulfadiazine and cephalothin, deposition of precipitates in the conjunctival cavity is possible.
Special instructions:Control of intraocular pressure.
The use of a cornea after injury can lead to a slowing of its healing. With prolonged use - the development of secondary glaucoma, steroid cataracts.
Patients are advised not to drive for 30 minutes after using the drug and work with moving mechanisms.