Heparin sodium + Prednisolone + Lauromacrogol 600 (Heparinum natrium + Prednisolonum + Lauromacrogolum 600)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Anticoagulants

Local Anesthetics

Glucocorticosteroids

Included in the formulation
  • Hepatrombin G
    suppositories rect. 
    Hemofarm AD     Serbia
    • АТХ:

    C.05.B.A.53   Heparin in combination with other drugs

    C.05.B.A   Heparin-containing preparations for topical application

    Pharmacodynamics:

    Combination agent for topical application.

    Sodium Heparin

    Anticoagulant direct action. By activating antithrombin III accelerates its anticoagulant effect. It blocks the synthesis of thrombin, reduces the aggregation of platelets. Reduces the activity of hyaluronidase. Prevents formation and promotes resorption of existing thrombi, improves local blood flow, has anti-inflammatory and anti-edematous effect.

    Prednisolone

    By inhibition of phospholipase A activity2 and reducing the release of arachidonic acid from the phospholipids of cell membranes reduces the production of leukotrienes and prostaglandins. Reduces the main substance of the connective tissue, weakening the exudative and proliferative processes in the skin. Inhibits cellular kinins, which have proteolytic activity. Prevents the access of macrophages and T-sensitized lymphocytes to the foci of inflammation.

    It has anti-inflammatory, anti-edematous and anti-allergic effect. Reduces pain, itching and eczematous manifestations in the anorectal area.

    Lauromacrogol 600

    Helps sclerosis of hemorrhoids, has a local analgesic effect.

    Pharmacokinetics:The drug for topical application, systemic action on the body does not.
    Indications:

    It is used as a monotherapy and as part of the complex treatment of hemorrhoids and anal fissures. Used for thrombophlebitis of hemorrhoidal veins, inflammatory itching in the anus.

    ICD-10

    IX.I80-I89.I84   Hemorrhoids

    XI.K55-K63.K60   Fissure and fistula of the anus and rectum area

    XII.L20-L30.L29.3   Anogenital itching, unspecified

    Contraindications:Tuberculosis, bleeding, syphilis, individual intolerance, children under 12 years.

    Carefully:

    Thrombocytopenia, hypersensitivity.

    Pregnancy and lactation:

    Recommendations for FDA - Category C. Contraindicated during pregnancy and lactation.

    Dosing and Administration:

    Rectally, 1 suppository 2 times a day. Outer, in the form of ointment applications on the affected areas 2-4 times a day.

    The highest daily dose: 2 suppositories.

    The highest single dose: 1 suppository.

    Side effects:

    Allergic reactions.

    Overdose:

    Cases of overdose are not described.

    Treatment is symptomatic.

    Interaction:

    Clinically significant interactions are not described.

    Special instructions:

    It is used after emptying the bowels or performing a cleansing enema.

    Instructions
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