The pharmacological action is determined by the properties of the constituent components.
Heparin prevents the formation of blood clots, prevents coagulation of blood in the hemorrhoids, has anti-edematous action, promotes regeneration of connective tissue, accelerates healing and reduces the number of relapses of the disease. Heparin inhibits reactions that cause blood coagulation and form a fibrin clot. Heparin in this dosage in combination with plasma antithrombin III inhibits thrombosis, deactivating factor Xa, and also by inhibiting the conversion of prothrombin in
thrombin. Heparin inhibits the formation of a stable fibrin thrombus, inhibiting the activation of the fibrin-stabilizing factor.Heparin also exhibits an anti-inflammatory effect, affecting the endothelium of the vessels, preventing edema.
Prednisolone belongs to the group of synthetic glucocorticosteroids of medium duration, reduces the formation, release and activity of inflammatory mediators (histamine, kinin, prostaglandin, lysosomal enzymes). Suppresses the migration of cells to the site of inflammation; reduces vasodilation and increased vascular permeability in the focus of inflammation. Reduces exudation due to vasoconstrictor action. Suppresses the effect of macrophages, target cells, cytokines, which are involved in the development of allergic reactions. Prevents the access of sensitized T-lymphocytes and macrophages to target cells. It has anti-inflammatory, anti-exudative and anti-allergic effect, reduces inflammation and accompanying subjective sensations (itching, burning, pain, sensation of moisture due to eczematous changes) in the anorectal area.
Lidocaine has a local anesthetic effect, which is caused by blockade of voltage-dependent sodium channels, which prevents the generation of pulses in the endings of the sensory nerves and pain impulses along nerve fibers.The combined effect of the constituents of the drug achieves the best effect.