Hypersensitivity to the components of the preparation and plants of the family Compositae; pregnancy, breastfeeding, age under 18, progressive systemic diseases (tuberculosis, leukemia, multiple sclerosis, autoimmune diseases),diffuse diseases of connective tissue (collagenoses), AIDS and HIV infection, arterial hypertension, acute period of infectious diseases, increased excitability, epilepsy, craniocerebral trauma, brain diseases, insomnia, chronic liver diseases, alcoholism.