Included in the formulation
АТХ:G.03.C.A Natural and semi-synthetic estrogens
Pharmacodynamics:
The derivative of stilbene, a synthetic estrogen of a nonsteroidal structure. Has estrogenic activity on a par with natural estrone. Interacts with specific receptors, affecting the target organs. Stimulates the proliferation of the epithelium of the vulva, vagina, cervix, uterine walls and fallopian tubes. Increases the sensitivity of the myometrium and fallopian tubes to substances that stimulate their motor skills. Increases insulin sensitivity, helps accelerate the utilization of glucose. In high doses, inhibits erythropoiesis, delays sodium and water in the body, inhibits the secretion of follicle-stimulating hormone. In low doses, on the contrary, it stimulates the secretion of follicle-stimulating hormone. Promotes the ovulatory type of luteinizing hormone, facilitates menopausal symptoms, prevents the development of postmenopausal osteoporosis.
Pharmacokinetics:After oral intake quickly and completely absorbed in the gastrointestinal tract, after intramuscular injection, the maximum concentration in the blood plasma is achieved in 2-3 hours. Metabolism in the liver.
The half-life is 24 hours. Elimination by the kidneys.
Indications:
It is used to treat ovarian hypofunction: with amenorrhea, oligomenorrhea, hypomenorrhea, dysmenorrhea; with infertility, vaginitis (in postmenopausal women and girls), in breast cancer in women over 60, prostate cancer, in order to suppress lactation, with weakness of labor, hypertrichosis in women.
XIV.N80-N98.N91 Absence of menstruation, meager and rare menstruation
XIV.N80-N98.N95.1 Menopause and menopause in women
XIV.N80-N98.N95.3 Conditions associated with artificially induced menopause
II.C50 Malignant neoplasm of breast)
II.C60-C63.C61 Malignant neoplasm of prostate
IV.E20-E35.E28 Dysfunction of the ovaries
IV.E20-E35.E28.3 Primary ovarian failure
XIII.M80-M85.M81.0 Postmenopausal osteoporosis
XIII.M80-M85.M81.1 Osteoporosis after removal of ovaries
XIV.N40-N51.N40 Hyperplasia of the prostate
Contraindications:
Severe renal and hepatic insufficiency, cancer of female genital organs, breast cancer in women under 60, uterine bleeding of unknown origin, individual intolerance.
Carefully:
Hepatic insufficiency of moderate severity, increased individual sensitivity.
Pregnancy and lactation:
Recommendations for FDA - Category C.Contraindicated in pregnancy and lactation.
Dosing and Administration:
Inside, 2 mg 1-2 times a day.
The highest single dose: 2 mg (2 ml of 0.1% solution).
The highest daily dose: 4 mg.
When treating malignant neoplasms - intramuscularly:
The highest single dose: 60 mg (3 ml of 2% solution).
The highest daily dose: 100 mg (5 ml of 2% solution).
Side effects:
Central and peripheral nervous system: dizziness.
The cardiovascular system: thrombophilia.
Digestive system: nausea, vomiting.
Reproductive system: decreased libido, feminization in men.
Allergic reactions.
Overdose:
Increased side effects.
Treatment is symptomatic.
Interaction:
Increases the effectiveness of antiarrhythmic and hypolipidemic agents.
It reduces the effect of diuretics, anticoagulants and male sex hormones.
Anti-estrogenic agents (clomiphene and others) weaken the action of the drug, as it blocks estrogen receptors.
Preparations of thyroid hormones and folic acid enhance the effect of hexestrol.
Special instructions:
Before use, the drug should be heated to body temperature.