Clinical and pharmacological group: & nbsp

Glucocorticosteroids

Ophthalmic products

Other antibiotics

Included in the formulation
  • SofraDex®
    drops d / eye tion. 
  • АТХ:

    S.03.C.A.01   Dexamethasone in combination with antimicrobials

    Pharmacodynamics:

    Combination agent for topical application.

    Gramicidin C

    Increases the permeability of membranes of microbial cells, which leads to their death. Active against infectious agents of the oral cavity and pharynx.

    Dexamethasone

    Has anti-inflammatory, antipruritic, anti-allergic, decongestant and vasoconstrictive. It prevents the accumulation of neutrophils on the skin, reducing inflammatory exudate and production of lymphokines, inhibits the migration of macrophages, reduces the processes of infiltration and granulation.

    By inhibiting the activity of phospholipase A2 and reducing the release of arachidonic acid from the phospholipids of cell membranes, it reduces the production of leukotrienes and prostaglandins. Reduces the main substance of the connective tissue, weakening the exudative and proliferative processes in the skin. Inhibits cellular kinins, which have proteolytic activity.

    Framicetin

    Antibiotic from the group of aminoglycosides. It binds to the 30S subunit of the ribosome of the bacterial cell and disrupts the movement of the ribosome along the RNA strands.It also changes the processes of reading the code of the RhK, which leads to the synthesis of functionally inactive proteins. Is able to disrupt the permeability of the cytoplasmic membrane of microorganisms.

    Pharmacokinetics:

    The drug for topical application, systemic action on the body does not.

    Indications:

    It is used for the treatment of bacterial infections of the anterior part of the eye: blepharitis, conjunctivitis, keratitis, iridocyclitis, scleritis, eczema of the eyelids. Used for external otitis.

    VII.H00-H06.H01.0   Blepharitis

    VII.H10-H13.H10.2   Other acute conjunctivitis

    VII.H10-H13.H10.4   Chronic conjunctivitis

    VII.H15-H22.H15.0   Sclerite

    VII.H15-H22.H15.1   Episcleritis

    VII.H15-H22.H16   Keratite

    VII.H15-H22.H20.0   Acute and subacute iridocyclitis

    VII.H15-H22.H20.1   Chronic iridocyclitis

    VIII.H60-H62.H60   External otitis media

    Contraindications:

    Tuberculosis, fungal lesions, herpetic infection, glaucoma, perforation of the tympanic membrane, individual intolerance.

    Carefully:

    Pregnancy and lactation, infantile age.

    Pregnancy and lactation:

    Recommendations for FDA - category is not defined. It is used in pregnancy and lactation with caution.

    Dosing and Administration:

    Conjunctival, 1-2 drops every 1-2 hours during the day, then 1-2 drops 3-4 times a day.

    In the external auditory meatus, 2-3 drops 3-4 times a day.

    Side effects:

    Increased intraocular pressure, rarely - perforation of the cornea. With prolonged use (more than 7 days) - the development of subcapsular cataracts.

    Allergic reactions.

    Overdose:

    Cases of overdose are not described.

    Treatment is symptomatic.

    Interaction:

    Clinically significant interactions are not described.

    Special instructions:

    Monitoring of intraocular pressure.

    During the treatment of the eyes, it is not recommended to drive vehicles and work with moving mechanisms.

    Instructions
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