Guaifenesin + Paracetamol + Phenylephrine (Guaifenesin * + Paracetamol * + Phenylephrine *)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Different means

Included in the formulation
  • Wix Active Symptomax Plus
    powder inwards 
    Procter and Gamble Distributing Company, LLC     Russia
    • АТХ:

    N.02.B.E.51   Paracetamol in combination with other drugs, excluding psycholeptics

    Pharmacodynamics:

    Combined drug. Has analgesic, antipyretic, antihistamine, vasoconstrictive, sedative, bronchodilating and antitussive action.

    Guaifenesin

    Increases the activity of ciliated epithelium, increases the secretion of liquid components of bronchial mucus due to depolymerization of acidic polysaccharides. Increases the volume of sputum, reducing its viscosity and facilitating its evacuation from the respiratory tract.

    Paracetamol

    Has antipyretic, analgesic and anti-inflammatory effect. Inhibits cyclooxygenase, mainly in the central nervous system, affects the centers of pain and thermoregulation. It does not have a negative effect on water-salt metabolism and mucous membranes of the gastrointestinal tract, and therefore has little effect on the synthesis of prostaglandins in peripheral tissues.

    Phenylephrine

    α1-adrenomimetic. It causes a narrowing of the arterioles and reduces the permeability of the vessels of the nasal mucosa, reduces edema, facilitates breathing, reduces rhinorrhea and lacrimation.Causes pupil dilatation without affecting accommodation, lowers intraocular pressure in glaucoma
    Pharmacokinetics:

    Guaifenesin

    After oral administration, it is rapidly absorbed in the gastrointestinal tract. The maximum concentration in the blood plasma is reached after 25-30 minutes.

    Metabolism in the liver with the formation of the main metabolite - β- (2-methoxyphenoxy) lactic acid.

    The elimination half-life is 1 hour. Elimination by the kidneys.

    Paracetamol

    After oral administration, it is completely absorbed in the gastrointestinal tract. The maximum concentration in the blood plasma is reached in 20-30 minutes. The connection with plasma proteins is 15%. Penetrates through the blood-brain barrier, enters the breast milk.

    Metabolism in the liver by glucuronation and sulfation (80%) with the formation of inactive metabolites, about 17% is hydroxylated to active metabolites, which are subsequently deactivated after conjugation with sulfates and glutathione. With a lack of glutathione, these metabolites block the enzyme systems of the liver, causing necrosis of hepatocytes.

    Half-life is 2-3 hours. Elimination by the kidneys, about 3% unchanged.

    Phenylephrine

    After ingestion, up to 30% is absorbed in the gastrointestinal tract. The maximum concentration in the blood plasma is achieved after 3 hours. The connection with plasma proteins is 70%. Penetrates through the blood-brain barrier.

    Metabolism in the liver.

    The elimination half-life is 2 hours. Elimination by the kidneys.

    Indications:

    It is used to treat influenza and colds accompanied by headache, fever, rhinitis.

    ICD-10

    X.J00-J06.J00   Acute nasopharyngitis (runny nose)

    X.J00-J06.J06   Acute upper respiratory tract infections of multiple and unspecified sites

    X.J10-J18.J11   Influenza, virus not identified

    XIII.M70-M79.M79.1   Myalgia

    XVIII.R00-R09.R06.7   Sneeze

    XVIII.R50-R69.R50.0   Fever with chills

    XVIII.R50-R69.R51   Headache

    XVIII.R50-R69.R52.9   Pain, unspecified

    Contraindications:

    Bleeding in the gastrointestinal tract, phenylketonuria, deficiency of glucose-6-phosphate dehydrogenase, portal hypertension, anemia, leukopenia, thrombocytopenia, age 12 years, pregnancy and lactation, individual intolerance.

    Carefully:

    Gilbert's syndrome, viral hepatitis, old age, alcoholism.

    Pregnancy and lactation:

    Recommendations for FDA - category is not defined. Contraindicated in pregnancy and lactation.

    Dosing and Administration:

    Inside, 1 packet 3 times a day after 4 hours.

    The highest daily dose: 4 sachets.

    The highest single dose: 1 sachet.

    Side effects:

    Central and peripheral nervous system: weakness, drowsiness, hallucinations, impaired coordination of movements.

    Hemopoietic system: rarely - aplastic anemia, pancytopenia.

    Digestive system: dry mouth, constipation.

    Dermatological reactions: exfoliative dermatitis.

    Sense organs: diplopia.

    urinary system: difficulty urinating.

    Allergic reactions.

    Overdose:

    Necrosis of liver cells due to the formation of a toxic metabolite of acetaminophen - N-acetyl-p-benzoquinonimine.

    Treatment: application of donators SH-groups, precursors of the synthesis of glutathione-methionine and N-acetylcysteine ​​for 12 hours after an overdose.

    Interaction:

    Strengthens the effect of indirect coagulants and toxicity of chloramphenicol.

    The intake of ethanol in the treatment of the drug leads to the development of acute pancreatitis.

    Simultaneous use with stimulators of microsomal oxidation in the liver (barbiturates, rifampicin, ethanol, phenylbutazone, phenytoin) increases the toxicity of paracetamol.

    Reduces the risk of hepatotoxic effects of microsomal oxidation inhibitors (cimetidine).

    Special instructions:

    Monitoring of glucose and uric acid in the plasma, the composition of peripheral blood, the functional state of the liver.

    Patients during treatment are not recommended to drive vehicles and work with moving mechanisms.

    Instructions
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