Ibuprofen + Pitophenone + Fenpiperinia bromide - instructions for use, dose, side effects, contraindications

Clinical and pharmacological group: & nbsp

NSAIDs - Propionic acid derivatives

Included in the formulation

Novigan®

pills inwards

Dr. Reddy's Laboratories Ltd. India

АТХ:

M.01.A.E.51 Ibuprofen in combination with other drugs

Pharmacodynamics:

Combined drug.

Ibuprofen

Non-selectively suppresses COX₁ and COX₂, regulating the synthesis of prostaglandins. It indiscriminately suppresses synthetases of prostaglandins. Suppresses the production of anti-inflammatory cytokines. Violates the synthesis of arachidonic acid. Has analgesic, antipyretic and anti-inflammatory effect. Inhibits the aggregation of platelets. With long-term use has a desensitizing effect.

Pitophenone

Inhibits phosphodiesterase, resulting in cAMP accumulation and reducing the concentration of calcium ions within the cells, thereby reducing the smooth muscle tone of the vascular walls and internal organs: respiratory, gastrointestinal, genital, urinary system.

Fentipierinium bromide

m-holinolitik, relaxes the smooth muscles of internal organs.

Pharmacokinetics:

After ingestion fasting all drugs until 90% absorbed in the gastrointestinal tract. The maximum concentration in the blood plasma is achieved in 1-2 hours. The connection with plasma proteins is 99%.

Therapeutic effect develops after the reception. Metabolism in the liver.

The elimination half-life is 2 hours. Elimination by the kidneys.

Indications:

It is used for relief of mild to moderate pain syndrome with bile, intestinal and renal colic, dyskinesia of bile ducts, headache, migraine. Used for arthralgia, myalgia, sciatica.

ICD-10

VI.G40-G47.G43 Migraine

XI.K80-K87.K80 Gallstone disease [cholelithiasis]

XI.K80-K87.K82.8 Other specified diseases of the gallbladder

XIII.M20-M25.M25.5 Pain in the joint

XIII.M50-M54.M54.1 Radiculopathy

XIII.M50-M54.M54.3 Sciatica

XIII.M50-M54.M54.4 Lumbago with sciatica

XIII.M70-M79.M79.1 Myalgia

XIII.M70-M79.M79.2 Neuralgia and neuritis, unspecified

XIV.N20-N23.N23 Renal colic, unspecified

XIV.N80-N98.N94.4 Primary dysmenorrhea

XIV.N80-N98.N94.5 Secondary dysmenorrhea

XVIII.R10-R19.R10.4 Other and unspecified abdominal pain

XVIII.R50-R69.R51 Headache

XVIII.R50-R69.R52.0 Acute pain

XVIII.R50-R69.R52.2 Another constant pain

Contraindications:

Liver and kidney failure, hemophilia, asthma, gastric ulcer and duodenal ulcers, granulocytopenia, porphyria, lack of glucose-6-phosphate dehydrogenase, intestinal obstruction, angle-closure glaucoma, tachyarrhythmia, age under 16 years, pregnancy and lactation, hypersensitivity.

Carefully:

Ischemic heart disease, diabetes, arterial hypertension, peripheral arterial disease, anemia, hyperbilirubinemia, nephrotic syndrome.

Pregnancy and lactation:

Recommendations for FDA - Category C. Contraindicated in pregnancy and lactation.

Dosing and Administration:

Inside, for 1 hour or 3 hours after eating 1 tablet 3 times a day.

The highest daily dose: 3 tablets.

The highest single dose: 1 tablet.

Side effects:

Central and peripheral nervous system: dizziness, headache, irritability, increased excitability, confusion, hallucinations.

Respiratory system: bronchospasm, shortness of breath.

Hemopoietic system: anemia, agranulocytosis, leukopenia, thrombocytopenia.

The cardiovascular system: tachycardia, arterial hypertension, heart failure.

Digestive system: heartburn, gastralgia, aphthous stomatitis, hepatitis, pancreatitis, flatulence, diarrhea.

Dermatological reactions: hyperhidrosis, rash, Lyell's syndrome.

Sense organs: ringing in the ears, hearing loss, impaired vision, paresis of accommodation.

Urinary system: nephrotic syndrome, polyuria, cystitis, proteinuria, staining of urine in red.

Allergic reactions.

Overdose:

Nausea, anorexia, diarrhea, impaired consciousness, bradycardia, respiratory arrest.

Treatment is symptomatic. Effective hemodialysis.

Interaction:

Simultaneous use with other non-steroidal anti-inflammatory drugs leads to increased toxic effects.

Increases the concentration in the blood plasma of digoxin and probenecid.

Increases the toxic effects of preparations of gold, colchicine, methotrexate, lithium.

Strengthens the action of insulin and oral hypoglycemic agents.

Reduces the effects of diuretics and antihypertensive drugs.

Special instructions:

The drug is intended for short-term use, not more than 5 days.

The drug is not compatible with alcohol.

During the treatment it is not recommended to drive vehicles and work with moving mechanisms.

Instructions

Ibuprofen + Pitophenone + Fentpiperinium bromide (Ibuprophenum + Pitophenonum + Phenpiverinii bromidum)