Immunoglobulin is injected intramuscularly into the upper outer quadrant of the gluteus muscle or to the external surface of the thigh.
DO NOT INSERT.
Before the injection, the ampoule with the drug is kept for 2 hours at room temperature (20 ± 2) ° C. To prevent the formation of foam, the drug is drawn into the syringe with a needle with a wide lumen.
The dose of immunoglobulin and the frequency of its administration depend on the indications for use.
Prevention
Introduction before the tick bite
The drug can be used before a probable contact with tick-borne encephalitis virus - a tick bite in an endemic area (pre-exposure prevention).The protective effect manifests itself in 24-48 hours and lasts about 4 weeks. To maintain immune protection, in case of danger of infection, it is recommended to repeat the administration of immunoglobulin after 4 weeks.
For the purpose of prevention, the drug is administered intramuscularly once at a rate of 0.1 ml per 1 kg of body weight.
Introduction after a tick bite
For the purpose of emergency prophylaxis, the drug is administered primarily unvaccinated against tick-borne encephalitis or who received an incomplete vaccination course that noted the sucking of ticks in endemic areas, as well as suspected laboratory infection with tick-borne encephalitis virus.
In cases of increased risk of infection (infection of sucking tick, multiple bites or simultaneous suction of several mites), the drug is administered to vaccinated individuals.
In the case of a new contact with mites, it is possible to reapply the drug 1 month after the first administration.
In all cases, the drug should be administered at the earliest possible time from the date of the alleged infection, no later than the 4th day after the tick bite.
Prophylactic dosages of human immunoglobulin against tick-borne encephalitis
| Weight bodies | 5 kg | 10 kg | 20 kg | 30 kg | 40 kg | 50 kg | 60 kg | 70 kg | 80 kg |
| Scope injections | 0.5ml | 1.0ml | 2.0ml | 3.0ml | 4,0ml | 5,0ml | 6,0ml | 7.0ml | 8.0ml |
Treatment
With therapeutic purpose, immunoglobulin is administered at the earliest possible time after the onset of the disease in various dosages, depending on the body weight, the clinical form of the infection, the severity of the course and the period of the disease.
- Patients with erased and abortive forms of tick-borne encephalitis (febrile forms of infection), immunoglobulin is administered daily in a single dose of 0.1 ml / kg of body weight, 3-5 days before the regression of common infectious symptoms (general improvement, disappearance of fever). The average course dose for an adult is at these forms at least 21.0 ml of the drug;
- with meningeal form of tick-borne encephalitis The drug is used daily in a single dose of 0.1 ml / kg of body weight at intervals of 10-12 hours for at least 5 days until the patient's overall condition improves on objective indicators (disappearance of fever, regression of common infectious symptoms, stabilization and reduction of meningeal symptoms). The average course of an immunoglobulin for an adult is at least 70.0 ml.
- patients with focal forms of tick-borne encephalitis depending on the severity of the disease, the drug is administered daily in a single dose of 0.1 ml / kg of body weight with an interval of 8-12 hours for at least 5-6 days before the temperature decreases and the neurological symptoms stabilize. The average course dose for an adult is not less than 80.0-130.0 ml of immunoglobulin.
In extremely severe disease, a single dose of the drug can be increased to 0.15 ml / kg body weight.
If specific meningeal and focal forms of tick-borne encephalitis have not been carried out for any reason in the febrile stage of the disease, it is possible to administer the immunoglobulin at the acute stage of the apyrexia for a 5-6 days in a single dose of 0.1 ml / kg body weight after 10-12 hours.
In the case of a two-wave flow of tick-borne encephalitis, the drug is used repeatedly according to the scheme of treatment of meningeal or focal forms depending on the nature of the clinical manifestations.