Included in the formulation
Included in the list (Order of the Government of the Russian Federation No. 2782-r of 30.12.2014):VED
АТХ:J.06.B.B.08 Staphylococcal human immunoglobulin
Pharmacodynamics:It binds staphylococcal exotoxin due to the high content of antibodies that have specific activity against staphylococcal exotoxin.
Pharmacokinetics:After intramuscular injection, the maximum concentration in the blood plasma is reached after 24 hours.
The half-life is 4-5 weeks.
Indications:It is used to treat diseases caused by staphylococcal infection.
I.B95-B97.B95.6 Staphylococcus aureus as the cause of diseases classified elsewhere
I.B95-B97.B95.7 Other staphylococci as a cause of diseases classified elsewhere
XXI.Z20-Z29.Z29.1 Prophylactic immunotherapy
Contraindications:Individual intolerance.
Carefully:Allergic diseases in the anamnesis, autoimmune diseases.
Pregnancy and lactation:Recommendations for FDA - Category C. It is used in pregnancy and lactation only for life indications.
Dosing and Administration:Use in children
Less than 5 years with generalized staphylococcal infection, the minimum dose is 100 IU.
Adults
Intramuscularly, at 5 IU / kg daily or every other day. 3-5 injections per course of treatment.
Side effects:Local (edema, infiltration at the injection site) and allergic reactions.
Overdose:Cases of overdose are not described.
Treatment is symptomatic.
Interaction:Compatible with all drugs, including antibiotics.
Reduces the effectiveness of active immunization against rubella, chicken pox, measles, mumps. It is recommended to use antiviral vaccines 3 months after the application of the anti-staphylococcal immunoglobulin.
Special instructions:After the introduction of immunoglobulin, a passive increase in the antibody content in the patient's blood is noted, which can lead to erroneous false positive interpretation of the results of serological testing.