Ingarone® (Ingaron®)

INGARON® - recombinant interferon gamma human, consists of 144 amino acid residues (aa), is deprived of the first three a. about. Cys-Tyr-Cys, replaced by Met. Molecular weight 16.9 kDa. It was obtained by microbiological synthesis in a recombinant strain of Escherichia coli and purified by column chromatography. Specific antiviral activity on cells (human fibroblasts) infected with vesicular stomatitis virus is 2 * 107 U / mg protein. Interferon Gamma (immune interferon) is the most important anti-inflammatory cytokine, the producers of which in the human body are natural killer cells, CD4 Th1 cells and CD8 cytotoxic suppressor cells. Receptors for interferon gamma have macrophages, neutrophils, natural killer cells, cytotoxic T-lymphocytes.Activates the effector functions of these cells, in particular their microbicide, cytotoxicity, their production of cytokines, superoxide and nitroxide radicals (thereby causing the death of intracellular parasites). Interferon Gamma blocks the replication of viral DNA and RNA, the synthesis of viral proteins and the assembly of mature viral particles. This causes a cytotoxic effect on the virus-infected cells.

Inhibits the B-cell response to interleukin-4, inhibits the production of IgE and the expression of CD23 antigen. It is an inducer of apoptosis of differentiated B cells, giving rise to autoreactive clones. Suppresses the suppressive effect of interleukin-4 on interleukin-2-dependent proliferation and generation of lymphokine-activated killers. Activates the production of proteins of the acute phase of inflammation, enhances the expression of the C₂ and C₄ components of the complement system. Unlike other interferons, it increases the expression of MHC antigens of both the first and second classes on different cells, and induces the expression of these molecules even on those cells that do not express them constitutively. This improves the efficiency of antigen presentation and the ability to recognize them by T lymphocytes.