Intravenous (jet or drip for 30 minutes) or intramuscularly.
For intramuscular administration, the contents of the vial with 250 mg, 500 mg, 1000 mg of Isodep® are dissolved in 2 ml, 5 ml, 10 ml of water for injection, respectively.
For intravenous fluid administration, the contents of the vial of 250 mg, 500 mg, 1000 mg or 2000 mg of Isodep® are dissolved in 2 ml, 5 ml, 10 ml or 20 ml of 0.9% sodium chloride solution, Ringer's solution, 5% dextrose solution, 5 % solution of fructose.
For intravenous drip administration, 250 mg, 500 mg, 1000 mg or 2000 mg of the drug are dissolved respectively in 25 ml, 50 ml, 100 ml or 200 ml of 0.9% sodium chloride solution, Ringer's solution, 5% dextrose solution, 5% fructose solution.
The daily dose is administered 2 times, with an interval of 12 hours.
With infections of the urinary system, skin or soft tissues, the daily dose is 2 g (in severe cases, the dose may be increased to 4 g); with respiratory infections - 2-4 g; at a sepsis and infections against a background of a neutropenia - 4.
The duration of treatment depends on the severity and characteristics of the course of the infectious process, the sensitivity of the microflora and is determined individually by the attending physician, usually 5-10 days.
If the renal function is impaired, dose adjustment is performed depending on the QC. The first dose (initial) is 1-2 g, in the future, with KK 5-20 ml / min 0.5-1 g administered once a day; with KK 20-50 ml / min - 0.5-1 g 2 times a day. In patients on hemodialysis, the daily dose is 0.5-1 g; after each procedure of hemodialysis, add 0.25-0.5 g.