Isoniazid + Levofloxacin + Pyrazinamide + Rifampicin + [Pyridoxine] (Isoniazidum + Levofloxacinum + Pyrazinamidum + Rifampicinum + [Pyridoxinum])

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Included in the formulation
  • Levofloripin®
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    M. J. Biofarm Pvt. Ltd.     India
    • Included in the list (Order of the Government of the Russian Federation No. 2782-r of 30.12.2014):

    VED

    АТХ:

    J.04.A.M   Combinations of antituberculous drugs

    Pharmacodynamics:

    Combined anti-tuberculosis drug

    Isoniazid

    Inhibits the enzymes necessary for the synthesis of mycolic acids, which are the main structural fragments of the cell walls of mycobacterium tuberculosis.

    The most intensive synthesis of mycolic acids is carried out in growing cells, so isoniazid has a bactericidal action on them, and bacteriostatic action on mature cells.

    The high selectivity of the chemotherapeutic effect of isoniazid is due to the fact that there are no mycolic acids in the tissues of the macroorganism, as well as in other microorganisms.

    Levofloxacin

    The broad-spectrum antibacterial drug inhibits the synthesis of DNA by blocking the DNA gyrase and topoisomerase IV, breaks the cross-linking of DNA breaks, destroys the cytoplasm, cell wall and bacterial membranes. It acts on extra- and intracellularly located microorganisms.

    It is active against Mycobacterium avium and Mycobacterium tuberculosis.

    Pyrazinamide

    In the body it turns into pyrazinic acid, which is active only in acidic medium (foci of caseous decay). Prevents the synthesis of mycolic acid, the main substrate of mycobacterium tuberculosis membranes.

    Rifampicin

    Semisynthetic antibacterial agent of bactericidal action. Selectively inhibits the DNA-dependent and RNA polymerase of mycobacteria tuberculosis and leprosy.

    Pyridoxine

    Vitamin B6. In the body, phosphorylation is converted to pyridoxal-5-phosphate, which is part of the enzymes involved in the decarboxylation, transamination and racemization of amino acids. Prevents the development of peripheral polyneuropathy, which develops due to the impact of anti-tuberculosis drugs.

    Pharmacokinetics:

    Not described.

    Indications:

    It is used for the treatment of tuberculosis of any form and localization.

    ICD-10

    I.A15-A19.A15   Tuberculosis of respiratory organs, confirmed bacteriologically and histologically

    Contraindications:

    Peptic ulcer of stomach and duodenum, cardiovascular insufficiency, epilepsy, propensity to convulsive seizures, violations of liver and kidney function, age under 18, pregnancy and lactation, individual intolerance.

    Carefully:

    Atherosclerosis, psoriasis, bronchial asthma, diseases of the nervous system, eczema in the phase of exacerbation, myxedema.

    Pregnancy and lactation:

    Recommendations for FDA - Category C. Contraindicated in pregnancy and lactation.

    Dosing and Administration:

    Inside, 1 tablet 1 time / day in the first half of the day.

    The highest daily dose: 1 tablet.

    The highest single dose: 1 tablet.

    Side effects:

    Central and peripheral nervous system: memory disorders, insomnia, mental disorders disorders, euphoria, peripheral neuritis, muscle twitching.

    Hemopoietic system: eosinophilia, anemia, pancytopenia, agranulocytosis, porphyria, hemorrhages.

    The cardiovascular system: tachycardia, pain in the heart.

    Digestive system: nausea, vomiting, diarrhea, hyperbilirubinemia, jaundice, hepatomegaly, dysbiosis, rarely - toxic hepatitis.

    Musculoskeletal system: muscle weakness, myalgia, arthralgia, rupture of tendons, rhabdomyolysis.

    Dermatological reactions: acne, Lyell's syndrome, urticaria, photosensitivity.

    Sense organs: optic neuritis, decreased sense of smell, hearing, tactile and taste sensitivity.

    urinary system: interstitial nephritis, dysuria, acute renal failure.

    Reproductive system: dysmenorrhea.

    Allergic reactions.

    Overdose:

    Metabolic acidosis, neurotoxic effect: dysarthria, lethargy, disorientation, hyperreflexia, convulsions, coma.

    Treatment is symptomatic. Effective hemodialysis.

    Interaction:

    Strengthens the action indirect hemocoagulants.

    Inhibits the metabolism of benzodiazepines, phenytoin and theophylline.

    Simultaneous use with paracetamol and other hepatotoxic substances increases the risk of developing toxic hepatonecrosis.

    Antatsidnye means slow down and reduce the absorption of isoniazid in the intestine, it is recommended to take them with an interval of 1 hour.

    With the simultaneous use of certain fish species (tuna, sardinella) and cheeses (Swiss), there may be hyperemia of the skin, itching, headache due to isoniazid suppression of monoamine oxidase and diamino oxidase activity in the blood plasma and metabolic disturbances of histamine and tyramine.

    Special instructions:

    It is recommended to use reliable contraceptive methods during taking the drug.

    In the treatment it is not recommended to drive vehicles and work with moving mechanisms.

    Instructions
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