Active substanceMethyl ethylpyridinolMethyl ethylpyridinol
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  • Dosage form: & nbspsolution for intravenous and intramuscular administration
    Composition:Methyl ethylpyridinol hydrochloride (emoxypine) 30 g; sodium phosphate di-substituted 12-aqueous (sodium hydrogen phosphate to decahydrate) - 7.0 g, sodium sulphite (sodium sulfite) -1.0 g, water for injection - up to 1 liter.
    Description:Transparent colorless or slightly colored liquid.
    Pharmacotherapeutic group:Antioxidant
    ATX: & nbsp

    S.01.X.A   Other drugs for the treatment of eye diseases

    Pharmacodynamics:

    Cardioksipin reduces the permeability of the vascular wall, the viscosity and coagulability of blood, the ability of erythrocytes to glue. Strengthens the process of fibrinolysis. Improves microcirculation.

    Effectively inhibits free radical oxidation of lipids of biomembranes, increases the activity of antioxidant enzymes. Stabilizes cytochrome P-450, has an antitoxic effect. In extreme situations, accompanied by increased lipid peroxidation and hypoxia, it optimizes bioenergetic processes.

    The drug protects the retina from the damaging effect of high-intensity light, promotes resorption of intraocular hemorrhages.

    Cardiocipine reduces the signs of cerebral hemodysfunction. Increases brain resistance to hypoxia and ischemia. With violations of cerebral circulation (ischemic and hemorrhagic) contributes to the correction of vegetative dysfunctions, facilitates the restoration of integrative activity of the brain, improves mnestic functions.

    Has hypolipidemic action, reduces the synthesis of triglycerides.

    The drug has a pronounced cardioprotective effect. Expands coronary vessels, reduces ischemic damage to the myocardium. With myocardial infarction limits the magnitude of the focus of necrosis, accelerates reparative processes, contributes to the normalization of myocardial metabolism. Has a beneficial effect on the clinical course of myocardial infarction, reducing the incidence of acute heart failure. Promotes regulation of the oxidation-reduction system in case of circulatory failure.

    Effective in conditions accompanied by increased lipid peroxidation (including skin diseases, glaucoma, etc.).

    Pharmacokinetics:When intravenously administered at a dose of 10 mg / ml, a low half-elimination period (T1 / 2 - 18 min, indicating a high rate of elimination of the drug from the blood.The value of the elimination constant is 0.041 min; total clearance CI -214.8 ml / min, apparent volume of distribution Vg. - 5.2 liters. The drug quickly penetrates into the organs and tissues, where it is deposited and metabolized. 5 metabolites of car-dioxypin, represented by dealkylated and conjugated products of its transformation, were detected. Metabolites of cardiocapine are excreted by the kidneys. In significant quantities, 2-ethyl-6-methyl-3-hydroxypyridine phosphate is found in the liver.
    Indications:

    In neurology and neurosurgery: hemorrhagic stroke in the recovery period, ischemic stroke, transient disorders of cerebral circulation, chronic cerebral circulatory insufficiency, craniocerebral trauma, accompanied by bruises of the brain; postoperative period in patients with craniocerebral trauma, operated for epi-, subdural and intracerebral hematomas, combined with bruises of the brain.

    In cardiology: acute myocardial infarction, prevention of "reperfusion syndrome", unstable angina.

    Contraindications:

    The use of the drug is contraindicated for individual intolerance, pregnancy.

    During lactation it is not recommended to apply, becausethere is no conclusive safety data.

    Due to the lack of safety data, it is not recommended for children under 18 years of age.

    Dosing and Administration:Neurology, neurosurgery and cardiology begin with an intravenous drop (20-40 drops per minute) of 20-30 ml of a 3% solution of emoxipin (600-900 mg) in 200 ml of a solution of sodium chloride isotonic or 5% glucose solution 1-3 times in day for 5-15 days depending on the course of the disease, followed by a transition to intramuscular injection of 2-10 ml of a 3% solution 2-3 times a day for 10-30 days.
    Side effects:With intravenous injection - a burning sensation along the vein, there may be an increase in blood pressure, agitation or drowsiness. When predisposed to allergic reactions in rare cases, there is an itching and redness of the skin.
    Interaction:α-Tocopherol acetate potentiates the antioxidant effect of cardiocipine. Cardiocipine should not be mixed with other injections in one syringe.
    Special instructions:Treatment with cardiocipine, in the case of its intravenous administration, should be carried out under the control of blood pressure and the functional state of the coagulation andanticoagulant systems of blood.
    Form release / dosage:Solution for intravenous and intramuscular injection 30 mg / ml.
    Packaging:

    1 ml or 5 ml into ampoules.

    10 ampoules of 1 ml are placed in carton boxes with a paper insert.

    5 ampoules of 1 ml or 5 ml are placed in a contour mesh package made of a polyvinyl chloride film. Two contour squares are placed in packs of cardboard.

    In each box or bundle, insert a knife ampoule or scarifier and instructions for use (when packaging ampoules with a break ring, dots, notches knife ampoule or scarifier do not invest).

    Storage conditions:In dry, protected from light and out of reach of children, at a temperature of no higher than 25 ° C.
    Shelf life:2 years. Do not use after the expiration date.
    Terms of leave from pharmacies:On prescription
    Registration number:LSR-001805/08
    Date of registration:17.03.2008
    Expiration Date:Unlimited
    The owner of the registration certificate:BIOSINTEZ, PAO BIOSINTEZ, PAO Russia
    Manufacturer: & nbsp
    Information update date: & nbsp10.12.2017
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