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Dosage form: & nbspconcentrate for solution for infusion
Composition:

1 liter of solution contains:

active substance: carnitine chloride 100 g;

adjuvant: water for injection up to 1 liter.

Description:

Transparent colorless or slightly yellowish liquid.

Pharmacotherapeutic group:Metabolic means
Pharmacodynamics:

Stimulates metabolic processes, participating in various links of energy metabolism. It has anabolic, antihypoxic and antithyroid effect, activates fat metabolism, stimulates regeneration, increases appetite.

Carnitine is a natural substance related to vitamins of group B. It is a cofactor of metabolic processes that ensure the maintenance of CoA activity. Reduces the basal metabolism, slows down the breakdown of protein and carbohydrate molecules. Promotes penetration through the membranes of mitochondria and the cleavage of long chain fatty acids (palmitic, etc.) with the formation of acetyl-CoA, necessary to ensure the activity of pyruvate carboxylase in the process of gluconeogenesis, the formation of ketone bodies, the synthesis of choline and its esters, oxidative phosphorylation and the formation of ATP. Mobilizes fat (the presence of 3 labile metal groups) from fat stores.Competitively superseding glucose, includes a fatty acid metabolic shunt whose activity is not limited by oxygen (in contrast to aerobic glycolysis), in connection with which the drug is effective in conditions of acute hypoxia (including brain) and other critical conditions. It has a neurotrophic effect, improves protein and fat metabolism, increased basal metabolism in thyrotoxicosis (being a partial antagonist of thyroxin).

It restores the alkaline blood reserve, does not affect the blood coagulation system, reduces the formation of keto acids, increases the resistance of tissues to the effect of toxic decomposition products, activates anaerobic glycolysis, has antihypoxic properties, stimulates and accelerates reparative processes.

Pharmacokinetics:

After 3 hours after intravenous administration, it is almost completely removed from the blood. Easily penetrates into the liver and myocardium, more slowly - into the muscles. It is excreted by the kidneys mainly in the form of acyl esters.

Indications:

Acute and recovery periods of ischemic stroke, transient disorders of cerebral circulation, discirculatory encephalopathy, traumatic and toxic brain lesions.

Contraindications:

Hypersensitivity. Pregnancy and lactation (due to lack of data).

Dosing and Administration:

Intravenously drip, slowly (no more than 60 cap / min). Preliminary, 5-10 ml of the solution (0.5-1 g) is diluted in 200 ml of 0.9% sodium chloride solution. In acute disorders of cerebral circulation - 1 g / day for the first 3 days, then 0.5 g / day for 7 days. After 10-12 days, repeated courses of 0.5 g / day are recommended for 3-5 days. In the subacute and recovery periods of stroke, with discirculatory encephalopathy, toxic and traumatic brain lesions - 0.5-1 g / day for 3-5 days. If necessary, after 12-14 days, appoint a second course.

Side effects:

Allergic reactions, muscle weakness in patients with uremia. With rapid administration (80 cap / min and more), pain along the vein can occur when the rate of administration is reduced.

Overdose:

Cases of overdose are unknown.

Interaction:

Glucocorticosteroids contribute to the accumulation of the drug in tissues (except the liver), other anabolic agents enhance the effect.

Form release / dosage:

Concentrate for the preparation of a solution for infusions of 100 mg / ml.

Packaging:

5 ml per ampoule.

5 ampoules are placed in a contour mesh package.

1 or 2 contour mesh packages together with the instruction for use and the ampoule scarifier are placed in a pack of cardboard.

When using ampoules with a break ring, it is allowed to pack the ampoules without an ampoule scarifier.

Storage conditions:

In the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

4 years.

Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:On prescription
Registration number:LSR-006466/09
Date of registration:13.08.2009
Expiration Date:Unlimited
The owner of the registration certificate:BELMEDPREPARATY, RUP BELMEDPREPARATY, RUP Republic of Belarus
Manufacturer: & nbsp
BELMEDPREPARATY, JSC Republic of Belarus
Information update date: & nbsp14.12.2017
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