Kestin® (Kestine®)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceEbastinEbastin
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  • Kestin®
    syrup inwards 
    Nycomed Denmark APS     Denmark
  • Kestin®
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    • Dosage form: & nbspsyrup
    Composition:

    1 ml of the preparation contains:

    Active substance:

    Ebastin

    1,000 mg

    Excipients:

    Lactic acid 85%

    6.600 mg

    Glycerol oxystearate

    10,000 mg

    Neohesperidin dihydrochalcone

    1.060 mg

    Anetol

    0.250 mg

    Sodium propyl parahydroxybenzoate

    0.300 mg

    Sodium methyl parahydroxybenzoate

    1,200 mg

    Glycerol

    200,000 mg

    Sorbitol solution 70%

    100,000 mg

    Dimethylpolysiloxane

    0.014 mg

    Sodium hydroxide

    to pH 4.2

    Distilled water

    1,000 ml
    Description:Transparent colorless or slightly yellowish solution with anise smell.
    Pharmacotherapeutic group:Antiallergic agent - H1-histamine receptor blocker
    ATX: & nbsp

    R.06.A.X.22   Ebastin

    Pharmacodynamics:

    After taking the drug inside, the expressed antiallergic effect begins after 1 hour and lasts for 48 hours. After a 5-day course of treatment with Kestin®, antihistamine activity persists for 72 hours due to the action of active metabolites. The drug has no pronounced anticholinergic and sedative effect. No effect of Kestin® on the interval QT ECG even in a dose of 80 mg.

    Pharmacokinetics:

    After oral administration, it is rapidly absorbed and almost completely metabolized in the liver, becoming an active metabolite of carabastine. After a single dose of 5 or 10 mg of the drug, the maximum plasma concentration of carbastine is reached after 2.8-3.4 hours and is 108-209 ng / ml. Fatty foods accelerate absorption (concentration in the blood increases to 50%). It is excreted by the kidneys - 60-70%, in the form of conjugates. With renal insufficiency T1/2 increases to 23-26 hours, with hepatic insufficiency - up to 27 hours. It does not penetrate the blood-brain barrier.

    Indications:

    - Allergic rhinitis seasonal and / or all-the-year-round (caused by household pollen, epidermal, food, drug allergens);

    - urticaria (can be caused by domestic, pollen, epidermal food, insect, drug allergens, exposure to the sun, cold, etc.);

    - allergic diseases and conditions due to increased release of histamine.

    Contraindications:Hypersensitivity to the drug, pregnancy, the period of breastfeeding.
    Carefully:

    With hepatic and / or kidney failure, childhood (up to 6 years).

    Use with caution in patients with increased QT-interval, hypokalemia.

    Pregnancy and lactation:

    The safety of the use of Kestina in pregnant women has not been studied, so taking Kestin® during pregnancy not recommended. Nursing mothers are not recommended to take Kestin®, as the release of ebastin into breast milk has not been studied.

    Dosing and Administration:

    Children from 6 to 12 years: 5 mg (5 ml) once a day.

    Children from 12 to 15 years: 10 mg (10 ml) once a day.

    Adults and children over 15 years of age prescribe 10-20 mg (10-20 ml) ofandn times a day.

    A daily dose of 20 mg is given on the recommendation of a doctor.

    Kestin® is taken regardless of food intake.

    Side effects:

    Headache, dry mouth.

    In rare cases - dyspepsia, nausea, insomnia, drowsiness, abdominal pain.

    Asthenic syndrome, sinusitis.

    Overdose:

    There is no special antidote for the drug. In case of an overdose, it is recommended to wash the stomach, monitor vital body functions. Symptomatic treatment.

    Interaction:

    It is not recommended to appoint Kestin® simultaneously with ketoconazole and erythromycin.

    Kestin® does not interact with theophylline, indirect anticoagulants, cimetidine, diazepam,ethanol and ethanol-containing preparations.

    Special instructions:If the liver function is impaired, the daily dose should not exceed 10 mg.
    Effect on the ability to drive transp. cf. and fur:

    Kestin® does not affect the ability to drive vehicles and machinery.

    Form release / dosage:Syrup, 1 mg / ml.
    Packaging:

    60 ml or 120 ml in a bottle of dark glass, sealed with a screw-on aluminum cap, into which a plastic gasket is inserted. Aluminum cap provides control of the first opening.

    One bottle, together with the instruction for use and a measuring device in the form of a syringe, is placed in a cardboard box.

    Storage conditions:At a temperature of 15 ° to 25 ° C in a dark place out of the reach of children.
    Shelf life:

    2 years.

    Do not use the drug after the expiration date.

    Terms of leave from pharmacies:Without recipe
    Registration number:П N015154 / 02
    Date of registration:07.10.2008
    Expiration Date:Unlimited
    The owner of the registration certificate:Nycomed Denmark APSNycomed Denmark APS Denmark
    Manufacturer: & nbsp
    Representation: & nbspNycomed Distribution Ltd.Nycomed Distribution Ltd.
    Information update date: & nbsp02.01.2018
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