Hypersensitivity to the components of the drug.
Known hypersensitivity to milk thistle (Silybum marianum) or otherwise plants of the family Compositae, as well as in case of hypersensitivity to quinine. Pregnancy and the period of breastfeeding due to the presence of celandine and chamois in the composition. Age to 18 years due to lack of clinical data.
Insufficiency of lactase, lactose intolerance, glucose-galactose malabsorption.