Active substanceTrypsin + ChymotrypsinTrypsin + Chymotrypsin
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  • Hymopsin®
    lyophilizate locally externally 
    SAMSON-MED, LLC     Russia
  • Dosage form: & nbsplyophilizate for solution preparation for local and external use
    Composition:

    In 1 bottle contains: as active substances - a mixture of trypsin and chymotrypsin - 50 mg.

    Description:Lyophilized powder or porous mass, in the form of a tablet or lumps of white or white with a weak yellowish hue of color.
    Pharmacotherapeutic group:Proteolytic agent
    ATX: & nbsp

    B.06.A.A.07   Trypsin

    B.06.A.A.04   Chymotrypsin

    Pharmacodynamics:Chymopsin is an enzymatic preparation of proteolytic action, it breaks down the necrotic tissue without affecting the living tissue, due to the presence of specific anti- enzymes in it. Liquefies viscous secrets and exudates.
    Indications:

    Suppurative bronchopulmonary diseases: bronchiectatic disease, lung abscess, atelectasis, exudative pleurisy (for liquefaction of thick viscous sputum and sanitation of the respiratory tract).

    Diseases of ENT organs: purulent sinusitis, purulent otitis (acute, subacute, chronic), eustachitis with viscous exudate, after tracheostomy to facilitate the removal of thick viscous exudate, chronic rhinitis.

    Burns, bedsores, trophic ulcers, purulent wounds (purging from purulent-necrotic masses, acceleration of healing).

    In ophthalmology: diseases of the cornea (ulcer, herpetic keratitis); burn of the mucous membrane of the eye, obstruction of the tear ducts, sluggish healing of the skin of the eyelids.

    Contraindications:

    Hypersensitivity to chemopsin.

    Chronic heart failure II-III degree, malignant neoplasms, pulmonary emphysema with respiratory failure, pulmonary tuberculosis (open form), dystrophy and cirrhosis of the liver, viral hepatitis, pancreatitis, hemorrhagic diathesis.

    Do not enter into bleeding cavities, apply to ulcerated surfaces of malignant tumors.

    Carefully:

    Empyema pleura tuberculosis etiology (resorption of exudate can contribute to the development of bronchopleural fistula).

    Pregnancy and lactation:

    Data on the use of the drug during pregnancy and during lactation are not present.

    Dosing and Administration:In diseases of the respiratory system, the drug in a dose of 25-30 mg is dissolved in 5 ml of distilled water and injected into the respiratory tract through an inhalation device, a bronchoscope, an endotracheal probe, a tracheostomy tube. The number of inhalations is from 1 to 3 times a day for several days, depending on the indications.Antibiotics, bronchodilators that enhance the action of chymopsin can be added to drug solutions.

    When chronic rhinitis is instilled or irrigated with Hymopsin solution, the nasal cavity 2-3 times a day (5 mg in 5 ml of 0.9 % solution of sodium chloride). With chronic purulent otitis complicated by cholesteatoma, after washing 0.9 % solution of sodium chloride is instilled in the ear with a 0.5% solution of Himopsin (by 0.9 % solution of sodium chloride) 2-3 times a day.

    With thermal burns of the third degree, a thin layer of Himopsin is applied to the corpse at a rate of 1 g per 100 cm of the wound surface and covered with a bandage soaked in 0.9 % solution of sodium chloride or 0.25% solution of procaine. A moisture-proof bandage is applied on top to slow the drying of the dressings. The bandages are changed every other day.

    In the treatment of purulent wounds and decubitus, the drug is used in doses of 25-50 mg (in 10-50 ml of 0.25% solution of procaine). The solution is moistened with sterile gauze tampons, which are applied to the wound surface for a period of 2 hours to 24 hours, depending on the thickness of the purulent-necrotic masses. Dressings with Hymopsin are changed every 3-5 days.

    In the treatment of ulcers, corneal burns and keratitis, Hymopsin is used in the form of eyebaths in a solution of 1: 500 daily for 2-3 days or as drops of 0.25% solution (prepared ex tempore) 4 times a day for 1-2 days for 2 drops.

    To treat the obstruction of the lacrimal ducts and skin lesions of the eyelids, the drug is applied as a 1% solution (prepared ex tempore), by irrigation of the wound and washing of the tear ducts.

    Side effects:

    There may be allergic reactions. After inhalation: occasionally hoarseness, irritation of the mucous membrane of the respiratory tract, rapidly passing subfebrial temperature.

    In ophthalmology: irritation and swelling of the conjunctiva can be noted; in such cases it is recommended to reduce the concentration of the drug used.

    Interaction:

    Not described.

    Special instructions:

    Before applying the drug to people prone to allergic reactions, you should enter a single therapeutic dose of antihistamines (subcutaneously or intramuscularly). In the next few hours after inhalations, the patient should carefully cough up phlegm or it should be removed by sucking.

    Form release / dosage:

    Liofilizate for solution for local and external use

    Packaging:50 mg (5 ml bottles). 10 Vials with instructions for use in cardboard pack.
    Storage conditions:

    In a dry place, protected from light and out of reach of children, at a temperature not exceeding + 20 ° ะก.

    Shelf life:

    3 years. Do not use after the date shown on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LS-000130
    Date of registration:18.02.2010
    The owner of the registration certificate:SAMSON-MED, LLC SAMSON-MED, LLC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp06.09.2015
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