Clenbuterol - instructions for use, dose, side effects, contraindications

Active substanceClenbuterolClenbuterol

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Clenbuterol

syrup inwards

Balkanfarm - Troyan AD Bulgaria

Clenbuterol

syrup inwards

Sopharma, AO Bulgaria

Clenbuterol Sopharma

pills inwards

Sopharma, AO Bulgaria

Dosage form: & nbspsyrup

Composition:

The content in 5 ml of syrup (or in g per 100 ml of syrup):

active substance: clenbuterol hydrochloride 0.005 mg (or 0.0001 g in 100 ml).

Excipients:

sorbitol 1400.0 mg (28.00 g), glycerol 1000.0 mg (20.00 g), propylene glycol 500.0 mg (10.00 g), sodium citrate dihydrate 23.9 mg (0.478 g ), citric acid monohydrate 35.0 mg (0.70 g), methyl parahydroxybenzoate 2.25 mg (0.045 g), propyl parahydroxybenzoate 0.25 mg (0.005 g), butyl parahydroxybenzoate 0.25 mg (0.005 g), sodium benzoate 6.0 mg (0.120 g), raspberry flavor 6.5 mg (0.013 g), purified water up to 5 ml (up to 100 ml).

Description:

Transparent, slightly viscous liquid with a specific smell of raspberry.

Pharmacotherapeutic group:Bronchodilator - beta2-adrenomimetic selective

ATX: & nbsp

R.03.A.C.14 Clenbuterol

Pharmacodynamics:

Selective beta₂-adrenomimetic, has a bronchodilator and secretolitic effect. Raising beta₂-adrenoceptors, stimulates adenylate cyclase, increases the content of cyclic adenosine monophosphate (cAMP) in cells, which, by affecting the protein kinase system, deprives myosin of the ability to bind to actin and leads to bronchodilation.Prevents bronchospasm caused by histamine, serotonin and acetylcholine. It causes the expansion of the vessels of the brain and skeletal muscles. Possesses tocolytic action. Side effects are associated with its ability, albeit poorly, to cause beta excitement1β-adrenoreceptors of the heart, as a result of which a positive foreign and chronotropic effect is manifested.

Has a slight anabolic effect, can increase body temperature.

The maximum effect of the drug is observed after 2-3 hours and continues until 6-8 hours.

Pharmacokinetics:

Well absorbed after oral administration.

Metabolized in the liver with education 8 metabolites (in minor amounts).

The release from the plasma passes in two phases. The half-life of the first phase is 1 hour, the second - 34 hours. Mostly it is excreted unchanged through the kidneys, with 87% of the dose taken within 168 hours.

Indications:

Symptomatic treatment of COPD, bronchial obstructive syndrome, bronchial asthma.

Clenbuterol syrup is not suitable for the symptomatic treatment of an acute asthmatic attack. Clenbuterol syrup can be used as an additional treatment for anti-inflammatory long-term therapy with corticosteroids or other anti-inflammatory drugs.

Contraindications:

Hypersensitivity to clenbuterol or to drug auxiliaries, thyrotoxicosis, tachyarrhythmia, hypertrophic obstructive cardiomyopathy, severe ischemic heart disease, myocardial infarction (acute, period), sugarase / isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption, pregnancy (I and III trimester) , lactation period.

Carefully:

Hyperthyroidism, diseases of the cardiovascular system (propensity to arrhythmias, heart defects, ischemic heart disease, hypertension), prostatic hyperplasia, diabetes mellitus, II trimester of pregnancy.

Pregnancy and lactation:

It is necessary to avoid prescribing the drug in the first 3 months of pregnancy due to possible adverse effects on fetal development. His appointment is not recommended in the last months of pregnancy and during childbirth due to the presence of tocolytic action of the drug and possible suppression of the tone of the uterus.

No special clinical studies of the penetration of the drug into breast milk, and therefore its appointment to lactating women is not recommended.

Dosing and Administration:

Inside, with meals, 2 times a day.

The dose in children is calculated depending on the age and body weight (from 0.0008 to 0.0015 mg of clenbuterol hydrochloride per kg of body weight per day).

Age	Body mass	Daily dose
up to 8 months	4-8 kg	5 ml
8-24 months	8-12 kg	10 ml
2-4 years	12-16 kg	15 ml
4-6 years old	16-22 kg	20 ml
6-12 years old	22-35 kg	30 ml

Children over 12 years and adults appoint 15 ml 2-3 times a day.

Patients sensitive to beta₂Sympathomimetics, as a rule, are prescribed a lower daily dose compared with the average recommended daily dose. In such patients, it may be effective to perform combined treatment with other drugs.

The daily intake for adults should not exceed 45 ml.

Simultaneously with the treatment with clenbuterol, prolonged anti-inflammatory therapy should be performed.

Side effects:

From the central nervous system: feelings of fear, mental disorders, hyperkinesis, sleep disorders, headache, general weakness redness of the face, sweating, trembling and anxiety, dizziness,in patients with Parkinson's disease, there may be an increase in tremor and muscle rigidity.

From the cardiovascular system: palpitations, tachycardia, decreased or (more often) increased blood pressure.

From the urinary system: decreased urine production associated with spasm of renal vessels and urinary retention associated with spasm of the sphincter of the bladder.

From the side of metabolism: as a result of stimulation of glycogenolysis in patients with diabetes mellitus, hyperglycemia may appear. The appearance of this side effect requires a reduction in the dose of the drug without discontinuing treatment.

From the digestive system: dry mouth, nausea.

Possible allergic reactions: skin rash; hives.

Other hypokalemia.

Overdose:

It is manifested by increased adverse reactions: arrhythmia, tachycardia, increased blood pressure, cardialgia, tremor of the extremities. There is a danger of hypokalemia after an overdose, so it is necessary to monitor the serum potassium concentration.

Treatment: gastric lavage, reception of activated carbon, use of water-salt solutions, symptomatic.

Interaction:

Beta-blockers due to antagonism with clenbuterol may reduce or eliminate its bronchodilator effect.

Reduces the effect of hypoglycemic drugs.

When used simultaneously with cardiac glycosides, monoamine oxidase inhibitors and theophylline, the risk of cardiac rhythm disturbances increases.

Reduces the effectiveness of antihypertensive drugs.

The effect of the drug is enhanced by tricyclic antidepressants, beta-adrenomimetics and anticholinergics. In combination with sympathomimetic drugs, toxicity increases.

Halothane and other inhaled anesthetics, as well as cyclopropane, can enhance the pro-arrhythmic effect of β₂-adrenomimetikov, including clenbuterol.

Special instructions:

Treatment of bronchial asthma can be carried out using a stepwise method in accordance with the severity of the disease under the regular supervision of a doctor.

Exceeding average daily doses of beta₂Sympathomimetics, such as Clenbuterol syrup, without the appointment of a doctor, can be dangerous for patients.The increasing need to increase doses taken is a sign of worsening of the course of the disease. A sudden and progressive increase in asthmatic complaints can pose a threat to life.

In this situation, the physician should revise the therapeutic regimen and, if necessary, create a new, by combining with anti-inflammatory drugs, dose adjustment of the existing anti-inflammatory therapy or additional inclusion of other medications.

When treating patients with sugar diabetesit is necessary to periodically check the concentration of glucose in the blood.

The use of the drug may lead to an increase in body weight due to the presence of anabolic effect, and when prescribed to athletes the drug may cause a false positive result in the conduct of doping control.

During treatment with the drug, the development of resistance and the syndrome of "ricochet" is possible.

The syrup contains, as auxiliary substances, methyl, propyl and butyl parahydroxybenzoates, which, although rare, can induce hypersensitivity reactions of immediate type.

Effect on the ability to drive transp. cf. and fur:

In connection with the possibility of tremors, dizziness and weakness, the drug can adversely affect the ability to drive and work with mechanisms, so during the treatment period, it is necessary to refrain from engaging in potentially dangerous activities requiring increased concentration of attention and speed of psychomotor reactions.

Form release / dosage:Syrup, 1 μg / ml.

Packaging:

For 100 ml of the drug in bottles of dark glass or dark polyethylene terephthalate, sealed with aluminum caps or caps made of polyethylene type "Pilfer-Proof."

Each bottle together with a measuring spoon or a measuring cup and instruction for use is placed in a cardboard pack.

Storage conditions:

In a dry and dark place at a temperature of no higher than 25 ° C.

Do not freeze!

Keep out of the reach of children!

Shelf life:

3 years.

Shelf life after opening the bottle is up to 1 month.

Do not use after the expiry date printed on the package!

Terms of leave from pharmacies:On prescription

Registration number:П N015306 / 01

Date of registration:14.08.2008 / 06.03.2017

Expiration Date:Unlimited

The owner of the registration certificate:Sopharma, AOSopharma, AO Bulgaria

Manufacturer: & nbsp

SOPHARMA, AD Bulgaria

Representation: & nbspSOFARMA SA SOFARMA SA Bulgaria

Information update date: & nbsp25.01.2018

Illustrated instructions

Instructions

Clenbuterol (Clenbuterol)