Clindovit® (Clindovit®)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbspgel for external use
Composition:

100 g of gel contain:

active substance: clindamycin phosphate in terms of clindamycin 1 g;

Excipients: methyl parahydroxybenzoate (Nipagin), allantoin, disodium lauriminodipropionata tocopheryl phosphate, propylene glycol, macrogol-400 (polyoxyethylene-400), carbomer copolymer, carbomer interpolymer, sodium hydroxide, purified water.

Description:

A colorless, almost transparent gel with a specific odor. Opalescence is allowed.

Pharmacotherapeutic group:Antibiotic-Lincosamide
Pharmacodynamics:

Clindamycin is an antibiotic of the lincosamides group, is active against all strains Propionibacterium acnes, the minimum inhibitory concentration (MIC) is 0.4 μg / ml. Inhibits the synthesis of proteins in the microbial cell due to interaction with the 50S-subunits of the ribosomes.

Clindamycin phosphate is inactive in vitro, but after application on the skin quickly hydrolyzed phosphatases at ducts of the sebaceous glands with the formation of clindamycin, possessing antibacterial activity. After application to the skin, the amount of free fatty acids on the skin surface decreases from about 14% to 2%.

Pharmacokinetics:

Clindamycin rapidly accumulates in comedones, where it exhibits antibacterial activity.The average concentration of antibiotic in the contents of comedones after application of the gel is significantly higher than the minimum inhibitory concentration for all strains Propionibacterium acnes - causative agent of acne. After application of 1% clindamycin phosphate gel to the skin in the blood plasma and urine, very low concentrations of clindamycin are determined.

Indications:

The drug is used to treat acne (acne vulgaris).

Contraindications:

Hypersensitivity to clindamycin or lincomycin in anamnesis, Crohn's disease, ulcerative and pseudomembranous colitis (including in the anamnesis).

Carefully:

Age under 12 years (no experience of use).

With caution should be used in patients with allergies, as well as with the simultaneous intake of muscle relaxants.

Pregnancy and lactation:

Perhaps the dermal application of the gel during pregnancy, if the intended benefit for the mother exceeds the potential risk to the fetus.

If it is necessary to use during lactation, it is recommended to stop breastfeeding.

Dosing and Administration:

Outwardly.

Gel a thin layer applied to the affected area of ​​the previously cleaned and dried skin 2-3 times a day.

The course of treatment: to obtain satisfactory results, treatment should be continued for 6-8 weeks, and if necessary, continue for up to 6 months.

Side effects:

The drug is usually well tolerated, however, with local application of the gel, irritation (at the site of application), burning, itching, dry skin, erythema, peeling, increased sebum secretion, contact dermatitis.

With resorption, there is a possibility of developing pseudomembranous enterocolitis.

Overdose:

No information.

Interaction:

Clindamycin and erythromycin are antagonists, as a result of which simultaneous use of these antibiotics is not recommended.

There is cross-resistance between clindamycin and lincomycin.

May enhance the effect of muscle relaxants, disrupting neuromuscular transmission.

Special instructions:

Whenshould be avoided contact with the eyes and oral cavity, and afterCarrying the gel should wash your hands.

Form release / dosage:

Gel for external use, 1%.

Packaging:

For 30 g in an aluminum tube.

Each tube together with instructions for use in a pack of cardboard.

Storage conditions:

At a temperature of 15 to 25 ° C.

Keep out of the reach of children.

Shelf life:

2 years.

Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe
Registration number:LSR-008001/10
Date of registration:12.08.2010 / 17.10.2016
Expiration Date:Unlimited
The owner of the registration certificate:AKRIKHIN HFK, JSC AKRIKHIN HFK, JSC Russia
Manufacturer: & nbsp
Representation: & nbspAKRIKHIN OJSC AKRIKHIN OJSC Russia
Information update date: & nbsp29.01.2018
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