Clopamide + Pindolol (Clopamidum + Pindololum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Beta-blockers

Diuretics

Included in the formulation
  • Viscaldix®
    pills inwards 
    EGIS ZAO Pharmaceutical Plant     Hungary
    • АТХ:

    C.07.C.A.03   Pindolol in combination with other diuretics

    Pharmacodynamics:

    Klopamid

    A non-azidic diuretic of medium strength, stimulates the excretion of sodium, chlorine, potassium, magnesium and water ions, preserves calcium ions. Due to the lower sodium content in the vascular wall, the sensitivity of the baroreceptors to vasoconstrictor influences decreases.

    Pindolol

    Non-selective beta-blocker with intrinsic sympathomimetic activity. Has antihypertensive, antiarrhythmic, antianginal action.

    Reduces the effect of catecholamines on the heart muscle, thereby reducing the heart rate, minute and shock volumes of blood.

    Eliminates the effects of arrhythmogenic factors: tachycardia, arterial hypertension, elevated cAMP content.

    Antianginal action is due to a decrease in myocardial oxygen demand with prolonged diastole and improved perfusion of the heart muscle.

    Blockade of β-receptors of bronchioles and bronchi can lead to an increase in bronchial resistance and bronchospasm.

    Pharmacokinetics:

    Klopamid

    After oral administration, up to 90% is absorbed in the gastrointestinal tract.The maximum concentration in the blood plasma is reached after 2 hours. The connection with plasma proteins is 46%.

    Metabolism in the liver.

    The half-life is 6-7 days. Elimination by the kidneys.

    Pindolol

    After oral administration, up to 98% is absorbed in the gastrointestinal tract. The maximum concentration in the blood plasma is achieved in 1-2 hours. The connection with plasma proteins is 60%.

    Metabolism in the liver.

    The elimination half-life is 3-4 hours. Elimination by the kidneys.

    Indications:

    It is used for the treatment of arterial hypertension, angina pectoris, supraventricular and ventricular extrasystole, hyperkinetic cardiac syndrome, hypertrophic cardiomyopathy. It is used in the complex therapy of pheochromocytoma.

    ICD-10

    II.D10-D36.D35.0   Benign neoplasm of the adrenal gland

    V.F40-F48.F45.3   Somatoform dysfunction of the autonomic nervous system

    IX.I10-I15.I10   Essential [primary] hypertension

    IX.I20-I25.I20   Angina pectoris [angina pectoris]

    IX.I30-I52.I42   Cardiomyopathy

    IX.I30-I52.I47.1   Nadzheludochkovaya tachycardia

    IX.I30-I52.I48   Atrial fibrillation and flutter

    IX.I30-I52.I49.4   Other and unspecified depolarization

    Contraindications:

    Cardiogenic shock, atrioventricular blockade of II-III degree, bradycardia, chronic heart failure,resistant to the action of cardiac glycosides, bronchial asthma, Addison's disease, renal and hepatic insufficiency, hypoglycemia, metabolic acidosis, simultaneous use of monoamine oxidase inhibitors, Raynaud's disease, Prinzmetal angina, age under 18, pregnancy and lactation, individual intolerance.

    Carefully:

    Psoriasis, chronic renal failure, depression.

    Pregnancy and lactation:

    Recommendations for FDA - Category C. Contraindicated in pregnancy and lactation.

    Dosing and Administration:

    Inside, 1 tablet once a day. It is possible to increase the dose to 2-3 tablets in 2 divided doses.

    The highest daily dose: 3 tablets.

    The highest single dose: 2 tablets.

    Side effects:

    Central and peripheral nervous system: dizziness, sleep disorders, with prolonged use possible development of depression.

    Respiratory system: bronchospasm.

    Hemopoietic system: thrombocytopenia, leukopenia, agranulocytosis.

    The cardiovascular system: arterial hypotension, bradycardia, Raynaud's syndrome.

    Digestive system: indigestion, diarrhea, or constipation.

    Musculoskeletal system: arthralgia, back pain, cramps calf muscles.

    Dermatological reactions: a rash, hives.

    Sense organs: "dry eye syndrome", transient visual impairment.

    Reproductive system: decreased potency, weakened libido.

    Allergic reactions.

    Overdose:

    Heart failure, swelling of the lungs, hallucinations.

    Treatment is symptomatic.

    Interaction:

    Strengthens hypoglycemic action of insulin and oral hypoglycemic agents.

    Pindolol is incompatible with alcohol.

    Sympatholytic and peripheral vasodilators enhance the effects of pindolol.

    Bronchodilators, adrenostimulators and sympathomimetics reduce the effects of pindolol.

    Indomethacin reduces the hypotensive effect of the drug.

    Clopamid increases the concentration of lithium in blood plasma.

    With the simultaneous use of clopamid with glucocorticosteroids, the risk of hypokalemia is increased.

    Special instructions:

    Before an operation, an anesthesiologist must be warned about taking the drug.

    In the treatment it is not recommended to drive vehicles and work with moving mechanisms.

    Instructions
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