Codeine + Caffeine + Paracetamol (Codeinum + Coffeinum + Paracetamolum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Anilides

Included in the formulation
  • Solpadein
    pills inwards 
    GlaxoSmithClean Consumer Helscher     United Kingdom
  • Solpadein
    capsules inwards 
    GlaxoSmithClean Consumer Helscher     United Kingdom
  • Solpadein
    pills inwards 
    GlaxoSmithClean Consumer Helscher     United Kingdom
    • АТХ:

    N.02.B.E   Anilides

    Pharmacodynamics:

    The opioid activity of codeine is due to the transformation into morphine. Weak agonist opioidnyh λ- and φ-receptors (activation of λ-receptors is 3 times stronger than φ): suppression of interneuronal transmission of pain impulses in the afferent ways of the central nervous system, a decrease in the emotional evaluation of pain and reaction to it.

    Caffeine inhibits cAMP phosphodiesterase by increasing the concentration of cAMP in the tissues of the brain, heart, and other organs.

    Exciting the centers of the vagus nerve, caffeine causes bradycardia (central action), relaxes the smooth muscles of other organs, including bronchi, slightly increases diuresis due to inhibition of reabsorption of electrolytes in the renal tubules.

    Analeptic action is due to the direct excitation of the respiratory and vasomotor center.

    Paracetamol is a non-narcotic analgesic, a derivative of para-aminophenol, an active metabolite of phenacetin.It has analgesic and antipyretic action. Anti-inflammatory activity is absent. The analgesic effect is associated with the inhibition of cyclooxygenase in the central nervous system. The effect on the serotonergic and cannabinoid systems of the brain is not excluded.

    Pharmacokinetics:

    The components of the drug are well absorbed into the digestive tract.

    Paracetamol penetrates the blood-brain barrier. Metabolised in the liver. It is excreted by the kidneys in the form of metabolites, mainly conjugates, only 3% unchanged.

    Caffeine is well absorbed in the intestines. It is excreted mainly by kidneys in the form of metabolites, about 10% - in unchanged form.

    Codeine slightly binds to plasma proteins. It is subject to biotransformation in the liver (10% by demethylation passes into morphine). It is excreted by the kidneys (5-15% - unchanged).

    Indications:

    Pain syndrome of small and medium intensity (headache and dental pain, neuralgia, myalgia, arthralgia, algodismenorea), fever for colds and other infectious and inflammatory diseases, acute respiratory viral infections.

    ICD-10

    XVIII.R50-R69.R52.9   Pain, unspecified

    XVIII.R50-R69.R52.2   Another constant pain

    XVIII.R50-R69.R52.0   Acute pain

    XVIII.R50-R69.R52   Pain, not elsewhere classified

    XVIII.R50-R69.R51   Headache

    XVIII.R00-R09.R07.0   A sore throat

    XVIII.R00-R09.R07   Sore throat and chest

    XIII.M70-M79.M79.6   Pain in the limb

    XIII.M20-M25.M25.5   Pain in the joint

    VII.H55-H59.H57.1   Eye Pain

    VI.G50-G59.G50.1   Atypical facial pain

    VI.G40-G47.G44.2   Headache of intense type

    XIII.M70-M79.M79.2   Neuralgia and neuritis, unspecified

    VI.G50-G59.G50.0   Neuralgia of the trigeminal nerve

    XVIII.R50-R69.R50   Fever of unknown origin

    XIV.N80-N98.N94.6   Dysmenorrhea, unspecified

    Contraindications:

    Hypersensitivity, deficiency of glucose-6-phosphate dehydrogenase, impaired liver or kidney function, blood diseases, bronchial asthma, conditions accompanied by respiratory depression, glaucoma, increased intracranial pressure, craniocerebral trauma, arterial hypertension, atherosclerosis, I trimester of pregnancy, breast-feeding, children's age (up to 12 years).

    Carefully:

    Stomach ulcer and duodenal ulcer (remission stage), elderly age, pregnancy - II and III trimesters.

    Pregnancy and lactation:

    The category of FDA recommendations is not defined.

    Contraindicated in pregnancy. During lactation, the use is permissible after consultation with the doctor.

    Dosing and Administration:

    Inside, after eating, adults - 1 tablet 3-4 times a day; the maximum single dose - 2 tablets, daily - 8 tablets. The course of treatment is no more than 5 days.

    Children and adolescents aged 12-18 years - in a single dose of 1 / 2-1 tablet, the maximum daily dose - 4 tablets. Course - no more than 3 days.

    The interval between receptions should be at least 4 hours.

    Side effects:

    From the nervous system and sensory organs: agitation, sleep disturbance.

    From the side of the cardiovascular system and blood (hematopoiesis, hemostasis): tachycardia, arrhythmia, thrombocytopenia, leukopenia, agranulocytosis.

    On the part of the digestive system: nausea, constipation.

    Allergic reactions: urticaria, skin rash, itching.

    Others: impaired liver or kidney function (with prolonged use).

    Overdose:

    Symptoms: nausea, vomiting, pain in the stomach, sweating, arrhythmia, respiratory failure, liver failure, coma, pale skin.

    Treatment: gastric lavage, the appointment of activated charcoal, symptomatic therapy.

    Interaction:

    When concomitantly with barbiturates, tricyclic antidepressants, rifampicin, ethanol increases the risk of hepatotoxicity (these combinations should be avoided).

    Long-term use of barbiturates reduces the effectiveness of paracetamol.

    With the joint use of caffeine and barbiturates, primidone, anticonvulsants (hydantoin derivatives, especially phenytoin) it is possible to increase metabolism and increase caffeine clearance; with the simultaneous administration of caffeine and cimetidine, oral contraceptives, disulfiram, ciprofloxacin, norfloxacin - a decrease in the metabolism of caffeine in the liver (slowing its elimination and increasing blood concentrations).

    Simultaneous use of caffeine-containing beverages and other CNS stimulating agents may lead to excessive stimulation of the CNS.

    Special instructions:

    It is possible to reduce the concentration and speed of psychomotor reactions, therefore, during the treatment period, care should be taken when driving vehicles and engaging in other potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.

    With prolonged, uncontrolled use, it is possible to develop addiction (weakening analgesic effect) and drug dependence.

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