Kofitsil-plus (Coficil-plus)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbsppills
Composition:

Active substances: acetylsalicylic acid - 300.0 mg, paracetamol 100.0 mg, caffeine (caffeine anhydrous) - 50.0 mg.

Excipients: potato starch 97.88 mg, sodium carboxymethyl starch (Type A) 30.00 mg, talc 11.20 mg, stearic acid - 5.60 mg, povidone (polyvinylpyrrolidone, Povidone K-17) - 4.00 mg, calcium stearate - 1.32 mg.

Description:

Tablets are white or white with a creamy shade of color, flat-cylindrical with a facet and a risk without odor or with a faint smell. Marble is allowed.

Pharmacotherapeutic group:Analgesic non-narcotic agent (non-steroidal anti-inflammatory agent + analgesic non-narcotic remedy + psychostimulating agent)
ATX: & nbsp
  • Acetylsalicylic acid in combination with psycholeptics
    • Pharmacodynamics:

    Kofitsil-plus - a combined drug, the effect of which is determined by the components that make up its composition.

    Acetylsalicylic acid has an analgesic, antipyretic, anti-inflammatory effect associated with the suppression of cyclooxygenases 1 and 2 regulating the synthesis of prostaglandins; inhibits the aggregation of platelets.

    Caffeine increases the reflex excitability of the spinal cord, excites the respiratory and vasomotor centers, dilates the blood vessels of skeletal muscles, brain, heart, kidneys,reduces aggregation of platelets; reduces drowsiness, a feeling of fatigue, increases mental and physical performance. Paracetamol has antipyretic, analgesic effect.

    Indications:Kofitsil-plus is used in adults with mild to moderate pain syndrome (headache, toothache, neuralgia, myalgia, thoracic radicular syndrome, lumbago, arthralgia, algodismenorea, migraine), in adults and children older than 15 years to reduce fever, with "colds" and other infectious inflammatory diseases.
    Contraindications:

    - Hypersensitivity to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (NSAIDs) or xanthines; hypersensitivity to other components of the drug;

    - erosive and ulcerative lesions of the gastrointestinal tract (in the phase of exacerbation), gastrointestinal bleeding;

    - marked violations of the liver or kidneys;

    - asthma, induced by the use of acetylsalicylic acid, salicylates and other non-steroidal anti-inflammatory drugs;

    - hemorrhagic diathesis (von Willebrand's disease, hemophilia, telangiectasia, hypoprothrombinemia, thrombocytopenia, thrombocytopenic purpura);

    - exfoliating aortic aneurysm;

    - deficiency of glucose-6-phosphate dehydrogenase;

    - portal hypertension, vitamin K deficiency;

    - increased excitability, sleep disturbance, anxiety disorders (agoraphobia, panic disorder);

    - organic diseases of the cardiovascular system (acute myocardial infarction, severe course of coronary heart disease, arterial hypertension), paroxysmal tachycardia, frequent ventricular extrasystole;

    - glaucoma;

    - surgical interventions accompanied by bleeding;

    - children under 15 years.

    Carefully:

    Hyperuricemia, urate nephrolithiasis, gout, peptic ulcer and / or duodenal ulcer (in the anamnesis), heart failure of severe degree.

    Pregnancy and lactation:

    Contraindicated in pregnancy during the I and III trimester, in the second trimester of pregnancy, one-time intake of the drug at recommended doses is possible only if the expected benefit for the mother does not exceed the potential risk to the fetus.

    If it is necessary to use the drug during lactation, breastfeeding should be stopped.

    Dosing and Administration:

    The drug is used inside after eating 1 -2 tablets 2-3 times a day.The maximum daily dose is 6 tablets. The interval between doses should be at least 4 hours. To reduce the irritant effect on the gastrointestinal tract, the drug should be taken after meals, washed down with water, milk, and alkaline mineral water.

    If there is a violation of the kidney or liver function, the break between doses is not less than 6 hours. The drug should not be taken more than 5 days with an appointment as an anesthetic and more than 3 days as an antipyretic. Other dosages and regimens are prescribed by the doctor.

    Side effects:

    Anorexia, nausea, vomiting, gastralgia, diarrhea, erosive-ulcerative lesions of the gastrointestinal tract, gastrointestinal bleeding, hepatic and / or renal insufficiency, increased blood pressure, tachycardia.

    Allergic reactions: skin rash, angioedema, bronchospasm.

    With long-term admission - dizziness, headache, visual disturbances, tinnitus, decreased platelet aggregation, hypocoagulation, hemorrhagic syndrome (epistaxis, bleeding gums, purpura, etc.), kidney damage with papillary necrosis; deafness; Stevens-Johnson syndrome,toxic epidermal nekrolosis (Lyell's syndrome), Reye's syndrome in children (metabolic acidosis of nervous system and psyche disorders, vomiting, liver dysfunction).

    Overdose:

    Nausea, vomiting, pain in the stomach, sweating, pallor of the skin, tachycardia. With light intoxication - ringing in the ears; severe intoxication - drowsiness, collapse, convulsions, bronchospasm, shortness of breath, anuria, bleeding. As the intoxication intensifies, progressive paralysis of respiration and dissociation of oxidative phosphorylation cause respiratory acidosis. If you suspect a poisoning, you should immediately seek medical help.

    Treatment: the affected person should do gastric lavage and prescribe adsorbents (Activated carbon).

    Interaction:

    Enhances the effect of heparin, indirect anticoagulants, reserpine, steroid hormones and hypoglycemic agents. Reduces the effectiveness of spironolactone, furoside, antihypertensive drugs, anti-gout agents that promote the excretion of uric acid.

    Increases the side effects of glucocorticosteroids, sulfonylurea derivatives, methotrexate, non-narcotic analgesics and non-steroidal anti-inflammatory drugs.

    It should be avoided combination of the drug with barbiturates, antiepileptic drugs, zidovudine, rifampicin and alcohol-containing beverages (increases the risk of hepatotoxic effect).

    Under the influence of paracetamol, the time of chloramphenicol elimination is increased by 5 times. Caffeine accelerates the absorption of ergotamine. Salicylamide, and other stimulants of microsomal oxidation contribute to the formation of toxic metabolites of paracetamol, which affect liver function. Metoclopramide accelerates the absorption of paracetamol. At repeated reception paracetamol can enhance the effect of anticoagulants (derivatives of dicumarin).

    Special instructions:

    With continued use of the drug, control of peripheral blood and the functional state of the liver is necessary. Because the acetylsalicylic acid has an antiaggregate effect, the patient, if he is to undergo surgery, must warn the doctor in advance about taking the drug. Acetylsalicylic acid in low doses reduces the excretion of uric acid. This can in some cases provoke a gout attack.

    During treatment, you should stop using alcohol-containing beverages (increased risk of gastrointestinal bleeding).

    Acetylsalicylic acid has a teratogenic effect: when applied in the first trimester of pregnancy leads to malformations - the cleavage of the upper palate; in the third trimester - promotes inhibition of labor (inhibition of the synthesis of prostaglandins), the closure of the arterial duct in the fetus, which causes hyperplasia of the pulmonary vessels and hypertension in the vessels of the small circulation. Acetylsalicylic acid is excreted in breast milk, which increases the risk of bleeding in the child due to a violation of the function of platelets.

    The drug is not prescribed as an anesthetic for people under 18 years of age, as an antipyretic agent - children under 15 years of age with acute respiratory infections caused by viral infections because of the danger of developing Reye's syndrome (encephalopathy and acute fatty liver disease with acute liver failure).

    Effect on the ability to drive transp. cf. and fur:During the treatment period, care must be taken when driving vehicles and occupationspotentially dangerous activities requiring increased concentration of attention and psychomotor reactions.
    Form release / dosage:

    Pills.

    Packaging:

    10 tablets in a contour mesh or cell-free packaging.

    1 or 2 contour mesh or non-cellular packages together with instructions for use in a pack of cardboard. Contour mesh or cellless packaging with an equal number of instructions for use in a group package.

    Storage conditions:

    Store at a temperature not exceeding 25 ° C. Keep out of the reach of children.

    Shelf life:

    3 years. Do not use after the expiration date printed on the package.

    Terms of leave from pharmacies:Without recipe
    Registration number:P N002781 / 01
    Date of registration:05.05.2008 / 21.12.2015
    Expiration Date:Unlimited
    The owner of the registration certificate:PHARMSTANDART-FORESTRY, OJSC PHARMSTANDART-FORESTRY, OJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp21.01.2018
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