Colbiocin (Colbiocin)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceSodium colistimethate + Tetracycline + ChloramphenicolSodium colistimethate + Tetracycline + Chloramphenicol
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  • Colbiocin
    ointment d / eye 
    SIIFI SpA     Italy
    • Dosage form: & nbspointment eye
    Composition:

    Ingredients per 100 g:

    Active substances: tetracycline - 0.5 g, chloramphenicol - 1.0 g, sodium colistimethate - 18000000 ME;

    Excipients: lanolin anhydrous - 15.0 g, paraffin liquid - 15.0 g, paraffin soft white - up to 100.0 g.

    Description:

    Soft mass of light yellow color.

    Pharmacotherapeutic group:Antimicrobial combination
    ATX: & nbsp

    S.01.A.A.20   Antibotics in combination with other drugs

    Pharmacodynamics:

    Combined antibacterial drug.

    Chloramphenicol - a broad-spectrum antibiotic, inhibits the synthesis of proteins of sensitive microorganisms; is active against gram-positive and gram-negative bacteria, Mycoplasma spp., Rickettsia spp., Chlamydia spp.; is not active with respect to Pseudomonas aeruginosa, mushrooms. Tetracycline - a broad-spectrum antibiotic, inhibiting bacterial protein synthesis at the RNA level, has a bacteriostatic effect. It is active against gram-negative bacteria, Chlamydia spp., Mycoplasma spp.. Rickettsia spp., Entamoeba histolytica. Stability of microorganisms develops slowly.

    Sodium colistimethate (colistin) is an antibiotic that is isolated from Bacillus polymixa, var. colistinus. Has a bactericidal effect on most gram-negative bacteria (incl. Pseudomonas spp., Haemophilus spp.). There is no cross-resistance with broad-spectrum antibiotics, with which colistin displays synergism.

    Pharmacokinetics:

    Chloramphenicol passes well through the hemato-ophthalmic barrier when applied topically. It is well distributed in body fluids (cerebrospinal fluid, bile, breast milk) penetrates the placental barrier. Sufficient concentrations are created in aqueous humor, partial systemic absorption occurs. The main way of excretion is through the kidneys.

    Tetracycline does not penetrate the tissues of the eye through intact epithelium. If the epithelium is damaged, the effective concentration of tetracycline in the moisture of the anterior chamber is reached 30 minutes after application. It enters the systemic circulation. The path of excretion is through the kidneys, the gastrointestinal tract.

    Sodium colistimethate has a low ability to penetrate the mucous membrane of the eye. Absorption of it increases with inflammation.

    Indications:

    In the complex therapy: bacterial blepharitis, blepharoconjunctivitis, bacterial conjunctivitis (catarrhal, purulent), chlamydial conjunctivitis, bacterial keratitis, purulent corneal ulcer, dacryocystitis.

    Contraindications:

    - Hypersensitivity to the components of the drug;

    - impaired liver function, kidney function;

    - in rare cases with prolonged use of bone marrow hypoplasia;

    - pregnancy and lactation;

    - children's age till 8 years.

    Dosing and Administration:

    A strip of ointment 1-1.5 cm long is placed behind the lower eyelid of the affected eye 3-4 times a day. If the application of ophthalmic ointment is combined with the application of Kolbiozin in the form of eye drops, then it is sufficient to apply the ointment once a day at night. For the introduction of the ointment, gently pull the lower eyelid down and, lightly pressing on the tube, insert into the conjunctival bag a strip of ointment. Then slowly release the eyelid and press it with a cotton swab or cotton swab for 1-2 minutes. After this, close your eyes for 1-2 minutes.

    The duration of treatment is 7-8 days. In case of severe course of conjunctivitis, blepharoconjunctivitis, keratitis, dacryocyst, and also with purulent ulcer of the cornea, the duration of treatment can be up to 14 days.

    Side effects:

    Transient blurred vision, local irritation (short-term conjunctival hyperemia).

    The cases of the appearance of symptoms of hypersensitivity in the form of burning, angioedema, urticaria, bullous and spotted-papular dermatitis have been reported. The appearance of the above-described symptoms requires discontinuation of the drug and the appointment of therapy.

    Overdose:

    There is no information about drug overdose.

    Interaction:

    With topical application of Kolbiocin, pharmacological interaction with other drugs has not been revealed.

    Special instructions:

    Since rare cases of bone marrow hypoplasia have been reported due to prolonged topical application of chloramphenicol, the drug should be prescribed for a short period of time and under the control of the pattern of peripheral blood.

    With long-term use, the stability of the pathogen develops.

    During treatment, it is necessary to control intraocular pressure.

    During the use of the drug is not recommended to wear contact lenses.

    In the case of Colbiocin ophthalmic ointment with other ophthalmic agents, the interval between the use of drugs should be 5-10 minutes.

    Effect on the ability to drive transp. cf. and fur:After applying the drug, a temporary decrease in the clarity of visual perception is possible and before its restoration it is not recommended to drive and engage in activities requiring increased attention and reaction.
    Form release / dosage:

    Ointment eye.

    Packaging:5 grams of ointment in an aluminum tube with a plastic tip closed with a plastic cap, with the control of the first opening. Tube with instructions for use in a pack of cardboard.
    Storage conditions:

    At a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    3 years.

    After opening the tube, the drug should be used within 30 days. Do not use the product after the expiry date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:П N014748 / 01
    Date of registration:25.02.2010 / 14.12.2017
    Expiration Date:Unlimited
    The owner of the registration certificate:SIIFI SpASIIFI SpA Italy
    Manufacturer: & nbsp
    Representation: & nbspNovaMedika, OOONovaMedika, OOORussia
    Information update date: & nbsp30.01.2018
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