Koldakt® Flu Plus (Coldact® Flu Plus)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceParacetamol + Phenylephrine + ChlorphenamineParacetamol + Phenylephrine + Chlorphenamine
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    • Dosage form: & nbspsustained-release capsules
    Composition:

    Each capsule contains:

    Active Ingredients:

    Chlorphenamine maleate 8 mg

    Paracetamol 200 mg

    Phenylephrine hydrochloride 25 mg

    Auxiliary Ingredients: talc 68.25 mg, hypromellose 4.5 mg, ethylcellulose 29 mg, diethyl phthalate 5.8 mg, microcrystalline cellulose 28.01 mg, povidone 6.41 mg, purified water qs, isopropanol qs, sodium disulfite 0.16 mg , disodium edetate 0.32 mg, dye crimson (Ponso 4R) 0.35 mg, dye yellow-yellow 0.01 mg, dye quinoline yellow 0.08 mg, granules Non Pared Seeds 18/22 (sugar grits: sucrose, molasses starch) 124.11 mg.

    Capsule shell: gelatin q.s. up to 100%, purified water 14-15%, methyl parahydroxybenzoate 0.8%, propyl parahydroxybenzoate 0.2%, dye azorubin 0.35%, dye crimson (Ponso 4R) 0.47%.

    * is lost in the production process

    Pharmacotherapeutic group:ARI and "colds" of symptoms remedy (analgesic non-narcotic means + alpha-adrenomimetic + H1-histamine receptor blocker)
    ATX: & nbsp

    N.02.B.E   Anilides

    N.02.B.E.51   Paracetamol in combination with other drugs, excluding psycholeptics

    Carefully:

    Congenital hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson syndrome and Rotor syndrome), bronchial asthma and chronic obstructive pulmonary disease.

    There is a risk of liver damage in patients with glutathione deficiency (eg, fasting).
    Dosing and Administration:

    Inside, adults and children over 12 years of age take 1 capsule every 12 hours for 3-5 days. Duration of admission as an antipyretic agent - no more than 3 days; as an anesthetic - no more than 5 days.

    Side effects:Increased blood pressure, tachycardia, drowsiness, dyspnoea, dizziness, increased excitability, dry mucous membranes, mydriasis, paresis of accommodation, increased intraocular pressure, decreased appetite, nausea, epigastric pain, anemia, very rarely urinary retention, allergic reactions (cutaneous rash, itching, hives, angioedema, rarely anemia, thrombocytopenia, leukopenia, agranulocytosis; at long reception in high doses probably hepatotoxic and nephrotoxic act, methemoglobinemia, thrombocytopenic purpura.
    Overdose:Symptoms overdosage caused by paracetamol, are manifested after taking more than 10-15 g: pallor of the skin, decreased appetite, nausea, vomiting, increased prothrombin time, increased activity of "hepatic" transaminases, hepatonecrosis, acute liver failure, epigastric pain.
    Acute liver failure can lead to encephalopathy, acute renal failure with tubular necrosis, metabolic acidosis, edema of the brain and death.
    Treatment: gastric lavage in the first 6 hours, introduction of donators SH-groups and precursors of glutathione-methionine synthesis 8-9 hours after an overdose and N-acetylcysteine ​​after 12 hours. In case of accidental overdose, immediately consult a doctor, regardless of whether any symptoms of an overdose are noted or not.
    Interaction:The risk of hepatotoxic action of paracetamol increases with the simultaneous administration of barbiturates, diphenin, carbamazepine, rifampicin, zidovudine and other inducers of microsomal liver enzymes.Strengthens the effects of sedatives, ethanol, inhibitors monoamine oxidase.
    Antidepressants, derivatives phenothiazine series, antiparkinsonian and antipsychotic drugs increase the risk of urinary retention, dryness in mouth, constipation.
    Glucocorticosteroids increase the risk of developing glaucoma. Paracetamol reduces the effectiveness of uricosuric drugs. Chlorphenamine simultaneously with furazolidone can lead to hypertensive crisis, agitation, hyperpyrexia.
    Tricyclic antidepressants strengthen the adrenomimetic effect of phenylephrine, the simultaneous administration of halothane increases the risk of ventricular arrhythmia. Reduces the hypotensive effect of guanethidine, which, in turn, increases alpha-adrenostimulating activity phenylephrine. With prolonged regular use of paracetamol, the anticoagulation effect of warfarin and other coumarin drugs increases and the risk of bleeding increases.
    Shelf life:2 years.
    Terms of leave from pharmacies:Without recipe
    Registration number:П N013266 / 01
    Date of registration:13.12.2007
    The owner of the registration certificate:Ranbaxy Laboratories LimitedRanbaxy Laboratories Limited India
    Manufacturer: & nbsp
    Representation: & nbspRABBAYS LABORATORY LIMITEDRABBAYS LABORATORY LIMITED
    Information update date: & nbsp10.09.2015
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