Immediately before the application of Callalizine®, the contents of the ampoule are dissolved in 0.5 % solution of novocain, 0.9 % solution of sodium chloride for injection or in water for injection.
The drug is administered subconjunctivally, directly into the lesion (spike, scar, vitreous, etc.) by electrophoresis, phonophoresis, and also applied dermally.
Before applying Kollalizina®, the sensitivity of the patient to the drug is checked,for which under the conjunctiva of the diseased eye, 1 KE is administered and 48 hours are observed. In the absence of an allergic reaction, treatment is performed. When the product is applied spontaneously, the skin is tolerated by skin, for which skin tests are performed with the application of a solution of Collalisin® in therapeutic doses for 24 and 48 hours.
1. For the prevention of post-burn symphylarphone Collalisin® is administered at 10 KE in 0.5 % solution of novocaine in the calcified arch after complete corneal epithelialization. Re-introduction is carried out after 2-3 days (after the reactivation of the previous injection subsided). The course of treatment is 2-3 weeks, the total dose of 60-70 KE, the number of injections - 5-7.
2. For the treatment of Simblefaron, keloid and other scars of the eyelids, Callalizin® is injected into the adhesion between the eyelid and the eyeball (immediately under the conjunctiva) or into the rumen at doses that cause limited necrosis - 100 KE in 0.5% solution of novocaine. The procedure is performed under close eye control using a binocular microscope. Repeated injection is performed 2-5 days after the reactivation subsides. To lick the adhesions between the eyelid and the eyeball, 3 injections are sufficient. The total dose is 300 KE, the duration of treatment is 3 weeks.
3. Treatment of narrowing of the tear ducts (tear ducts, tear duct) is performed by washing with Kollalizin® solution (daily or every other day) 50 KE in 2 ml of 0.5% solution of novocaine. The course of treatment is 7-10 procedures, the repeated course of treatment is possible in 2-3 weeks.
4. Treatment of corneal opacities, plastic iridocyclitis (posterior synechiae) and secondary cataracts are performed in one of the following ways:
a) Electrophoresis. Collalyzin® from the solution (50 KE with 10 ml of water for injection) is injected into the eye from the positive pole, the electric current is up to 1 mA, the duration of the procedure is up to 10 minutes. The course of treatment - 10 procedures, re-holding the course is possible in 2-3 weeks,
b) Phonophoresis. Collagenin® in a dose of 50 KE (in 10 ml of water for injection) is injected into the eye with the help of the "�?УТ 0,88 - 4 - 2" sensor of the "Ultrasonic T-5" device. The intensity is 0.2 W / cm, the duration of the procedure is 5 minutes. The course consists of 10 procedures, can be repeated after 2-3 weeks.
at) Electro-phonophoresis (a combination of two techniques). On the background of phonophoresis electrophoresis is connected. The duration of the procedures is as in points "a" and "b". A course of treatment can be repeated after 2-3 weeks.
d) Subconjunctival administration.Collagenin® daily or every other day is administered under the conjunctiva of the eyeball at a dose of 10 ICE in 0.2 ml of 0.5 % solution of novocaine. The course of treatment is 7-10 injections, the total dose of 70-100 KE. The second course is carried out after 2-3 weeks.
5. Treatment of opacities of the vitreous, organized hemophthalmia and cicatrical process in the retina is carried out by subconjunctival (see paragraph "4 g" above) or retrobulbar injections of Collalisin ® 'Retrobulbaric injections (under the tenon capsule) are produced every other day at a dose of 10 KE in 0.2 ml of 0 , 5% solution of novocaine. The course of treatment includes 7-10 injections, the total dose of 70-100 KE. Repeated courses can be conducted after 2-3 weeks.
6. For the treatment of traumatic hemorrhage in the vitreous Collysin® is administered once for 1 KE in 0.2 ml of 0.9 % solution of sodium chloride in the central zone of the vitreous body through the incision of the sclera in the region of the flat part of the ciliary body.
7. Nasal application of Collalisin ® is recommended for the prevention of rumen hypertrophy in patients after dermatology, used for the removal of scarring, facial wrinkles, for the prevention of scar formation after electrocoagulation of various skin lesions.Treatment begins in the postoperative period after complete healing of the wound or epithelization of the wound surface. Collalyzin® is applied to the scar every day at a dose of 500 KE c. 10 ml of water for injection. The course of treatment is 4-5 weeks, the total dose is 15,000-30000 KE.
For the prevention of scar formation in patients after excision of keloids with an increased tendency to excessive connective tissue proliferation (treatment start in the postoperative period after full healing of wounds or epithelization of the wound surface), and for treatment of hypertrophic scars and fresh growing keloids, for formed scarring prescription is not more than a year, the drug is recommended to use the method of electrophoresis. The aqueous solutions of Collalisin® are injected from the positive electrode for 20 minutes at a current of 0.03-0.1 mA per cm2. The course of treatment does not exceed 15 procedures every other day. A total of 2-3 courses of treatment at intervals of 2 months. The dose of Collalisin® for electrophoresis is selected taking into account the size, stage of development of the scar and its clinical manifestations. For the treatment of hypertrophic scars Kollalizin® appoint 500-1000 KE dissolved in 10 ml of water for injections a total dose 22500-45000 KE.For fresh growing cicatricial scars, with formed cicatrixes older than a year, and also after excision of keloid scars in individuals with an increased tendency to excessive proliferation of connective tissue, the drug is prescribed for 1000-2000 KE in 10 ml of water for injection at a total dose of 45,000- 900,000 KE ( on 3 courses of treatment).