Adverse reactions of the drug are systematized relative to each of the organ systems depending on the frequency of occurrence, using the following classification:
Very often (≥ 1/10);
Often (≥ 1/100, <1/10);
Infrequently (≥ 1/1000, <1/100);
Rarely (≥ 1/10000, <1/1000);
Very rarely (<1/10000), including isolated cases.
Immune system disorders:
Rarely, allergic dermatitis or hypersensitivity reaction.
Disturbances from the nervous system:
Often - headache, dizziness;
Very rarely - paresthesia, generalized tonic-clonic seizures.
Metabolic disorders:
Rarely - dehydration;
Very rarely - hyperphosphataemia, hypocalcemia, hypokalemia, hypernatremia, metabolic acidosis.
Disorders from the cardiovascular system:
Very rarely - myocardial infarction, arrhythmia, hypotension.
Disorders from the gastrointestinal tract:
Very often - diarrhea, abdominal pain, bloating, nausea;
Often - vomiting, abnormal colonoscopy (single or multiple aphthous ulcers localized in sigmoid colon or rectum, not clinically significant and spontaneously disappearing without therapy), abnormal gastroscopy (erythematous gastritis with lesions and / or necrotic superficial ulceration in the intestine, most often which are asymptomatic and spontaneously regressive)
General disorders and complications at the site of drug administration:
Very rarely: chills, asthenia.
Disturbances from the musculoskeletal and connective tissue:
Very rarely - muscle cramps.
Disorders from the kidneys and urinary tract:
Increase in the content of nitrogen in the urine, an increase in creatinine, acute renal failure, nephrocalcinosis, acute phosphate nephropathy, and acute tubular necrosis.