Active substancePolypeptides of the cerebral cortexPolypeptides of the cerebral cortex
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  • Cortexin®
    lyophilizate w / m 
    GEROPHARM, LLC     Russia
  • Cortexin®
    lyophilizate w / m 
    GEROPHARM, LLC     Russia
  • Dosage form: & nbsplyophilizate for the preparation of a solution for intramuscular injection
    Composition:

    1 bottle contains

    active substance - Cortexin 5 mg (complex of water-soluble polypeptide fractions);

    Excipients - glycine 6 mg (stabilizer).

    Description:

    Lyophilized powder or porous mass of white or white with a yellowish tinge.

    Pharmacotherapeutic group:Nootropic remedy
    ATX: & nbsp

    N.06.B.X   Other psychostimulants and nootropic drugs

    Pharmacodynamics:

    CORTEXIN® contains a complex of low molecular weight water-soluble polypeptide fractions that penetrate the blood-brain barrier directly to the nerve cells. The drug has nootropic, neuroprotective, antioxidant and tissue-specific effects.

    Nootropic - improves the higher functions of the brain, learning and memory processes, concentration of attention, stability under various stresses.

    Neuroprotective - protects neurons from damage by various endogenous neurotoxic factors (glutamate, calcium ions, free radicals), reduces the toxic effects of psychotropic substances.

    Antioxidant - inhibits lipid peroxidation in neurons, increases the survival of neurons in conditions of oxidative stress and hypoxia.

    Tissue-specific - activates the metabolism of neurons of the central and peripheral nervous system, reparative processes, improves the functions of the cerebral cortex and the general tone of the nervous system.

    Mechanism of action CORTEXIN® is due to the activation of peptides of neurons and neurotrophic brain factors; optimization of the balance of metabolism of excitatory and inhibitory amino acids, dopamine, serotonin; GABA-ergic effect; a decrease in the level of paroxysmal convulsive activity of the brain, the ability to improve its bioelectrical activity; prevention of the formation of free radicals (products of lipid peroxidation).

    Pharmacokinetics:

    The composition of CORTEXIN®, the active ingredient of which is a complex of polypeptide fractions, does not allow the usual pharmacokinetic analysis of individual components.

    Indications:

    In the complex therapy of cerebral blood flow disorders, craniocerebral trauma and its consequences, encephalopathies of various genesis,cognitive disorders (memory and thought disorders), acute and chronic encephalitis and encephalomyelitis, epilepsy, asthenic conditions (nassegmental vegetative disorders), reduced learning ability, delayed psychomotor and speech development in children, various forms of infantile cerebral palsy.

    Contraindications:

    Individual intolerance to the drug.

    Pregnancy and lactation:

    The drug is contraindicated in pregnancy (due to lack of data from clinical studies).

    If it is necessary to prescribe the drug during lactation, breastfeeding should be stopped (due to the lack of data from clinical trials).

    Dosing and Administration:

    The drug is administered intramuscularly.

    The contents of the vial before injection are dissolved in 1-2 ml of 0.5% solution of procaine (novocaine), water for injection or 0.9 % solution of sodium chloride (directing the needle to the wall of the vial to avoid foaming) and administered once daily: to children with a body weight of up to 20 kg at a dose of 0.5 mg / kg, with a body weight of more than 20 kg - 10 mg for 10 days.

    If necessary, repeat the course in 3-6 months.

    Side effects:Individual hypersensitivity to the components of the drug is possible.
    Overdose:

    At present, no cases of drug overdose have been reported.

    Interaction:

    Drug interaction of the drug is not described.

    Special instructions:

    Use CORTEXIN® only as directed by your doctor!

    When using a 0.5% solution of procaine (novocaine) as a solvent for CORTEXIN®, information should be kept on contraindications, precautions and age restrictions set forth in the instructions for the use of procaine (novocaine).

    The bottle with dissolved medicinal product can not be stored and used after storage.

    A solution of CORTEXIN® is not recommended for mixing with other solutions.

    Features of the drug during the first admission or when it is canceled are absent.

    In the case of missed injections, it is not recommended to administer a double dose, but to carry out the next injection as usual on the target day.

    Special precautions for the destruction of unused medications are not required.

    Effect on the ability to drive transp. cf. and fur:No data.
    Form release / dosage:Lyophilizate for solution for intramuscular injection, 5 mg.
    Packaging:

    11 mg per bottle with a capacity of 3 ml, 5 bottles per circuit cell packaging of polyvinylchloride or polyethylene terephthalate film and aluminum foil. 2 contour squares in a pack of cardboard together with instructions for use.

    Storage conditions:

    In the dark place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    3 years.

    Do not use after the expiry date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LSR-003190/09
    Date of registration:27.04.2009 / 22.09.2017
    Expiration Date:Unlimited
    The owner of the registration certificate:GEROPHARM, LLC GEROPHARM, LLC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp04.02.2018
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