Kwamatel mini - instructions for use, dose, side effects, contraindications

Excipients: silicon dioxide colloid - 0.50 mg, magnesium stearate - 1.00 mg, povidone K90 - 2.00 mg, sodium carboxymethyl starch (type A) - 3.00 mg, talc - 3.00 mg, corn starch - 28, 00 mg, lactose monohydrate - 52,50 mg.

Shell: iron oxide red - 0.0020 mg, silicon dioxide colloid - 0.0440 mg, titanium dioxide - 0.1480 mg, macrogol 6000 - 0.2495 mg; septiphilm 003 - 3,3065 mg (macrogol-40 stearate (type I) - 8,00-12,00%, microcrystalline cellulose 35,00-45,00%, hypromellose - 45,00-55,00%).

Description:

Round, biconvex tablets, covered with a coat of light pink color. On one side of the tablet is the "10" marking.

Pharmacotherapeutic group:Gland of the stomach secretion lowering agent - H2-histamine receptor blocker

ATX: & nbsp

A.02.B.A.03 Famotidine

Pharmacodynamics:

Famotidine is a blocker of histamine H₂receptors of parietal cells of the gastric mucosa. Reduces basal and stimulated secretion of hydrochloric acid, caused by irritation of baroreceptors, food load, action of hormones and biogenic stimulants (gastrin, histamine, pentagastrin). Famotidine reduces the volume of gastric juice and the content of hydrochloric acid in it, increases the pH of the contents of the stomach, which leads to a decrease in the activity of pepsin. Famotidine penetrates the placental barrier and is excreted in breast milk.

Pharmacokinetics:

Absorption is incomplete, the maximum concentration is 1-3 hours. Bioavailability is 40-45%, increases with food intake and decreases with antacids. The connection with plasma proteins is 10-20%.

The half-life from plasma is 2.3-3.5 hours, and with creatinine clearance <10 ml / min it can reach 20 hours (dose adjustment is required). 30-35% drug is metabolized in the liver with the formation of Soxide. When ingesting 30-35% of famotidine is excreted by the kidneys in an unchanged form.

Penetrates through the placental barrier, into breast milk and cerebrospinal fluid.

Indications:

Symptomatic treatment of dyspepsia associated with increased acidity of gastric juice (heartburn, acidic eructation, etc.).

Contraindications:

Hypersensitivity to famotidine or other components of the drug, pregnancy, the period of breastfeeding, children under 16 years of age.

Carefully:

Hepatic and / or renal failure, cirrhosis with portosystemic encephalopathy (in the anamnesis), immunodeficiency.

Dosing and Administration:

In case of heartburn or other symptoms of dyspepsia, one tablet of KVAMATEL® MINI should be taken. The tablet should be swallowed whole, washed down with a small amount of water.Do not use more than two tablets per day.

If symptoms persist for at least two weeks, the doctor should be consulted.

Side effects:

Rarely - allergic reactions (rash, itching of the skin, difficulty breathing), headache, dizziness, tinnitus, fatigue, drowsiness, changes in taste, dry mouth, nausea, vomiting, constipation, diarrhea, abdominal pain, decrease appetite, acute pancreatitis, bloating, impaired baking, muscle and joint pain, dry skin, alopecia, heart rhythm disturbance.

Very rarely - hemolytic anemia, angioedema, mnogomorfnaya erythema, exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, anaphylactic shock, anxiety, nervousness, depression, psychosis, mental confusion, hallucinations, gynecomastia, agranulocytosis, pancytopenia, neutropenia, leukopenia, thrombocytopenia.

Overdose:

Symptoms: vomiting, motor excitement, tremor, lowering blood pressure, tachycardia collapse.

Treatment: induction of vomiting and / or gastric lavage.

Symptomatic and maintenance therapy: with convulsions - diazepam in / in; bradycardia - atropine; ventricular arrhythmia-lidocaine. Hemodialysis is effective.

Interaction:

Increases the absorption of amoxicillin and clavulanic acid.

Antacids and sucralfate slow the absorption of famotidine.

Reduces the absorption of itraconazole and ketoconazole.

Drugs that depress the bone marrow increase the risk of developing neutropenia.

Special instructions:

Before taking KVAMATELA MINI, you should consult your doctor if you have a history of gastric and duodenal ulcers, porphyria, heart rhythm disturbances, liver and kidney failure, unmotivated weight loss, and other medications.

Smoking reduces the effectiveness of treatment.

Effect on the ability to drive transp. cf. and fur:The possibility of developing unwanted effects (see section "Side effect") should be taken into account when driving vehicles and performing work that requires a high rate of mental and physical reactions.

Form release / dosage:

Tablets, film-coated, 10 mg.

Packaging:

For 14 tablets in a blister of PVC-aluminum foil.One blister, along with instructions for use, is placed in a cardboard pack.

Storage conditions:

In the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years.

Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:П N014993 / 01

Date of registration:18.08.2008 / 31.05.2016

Expiration Date:Unlimited

The owner of the registration certificate:GEDEON RICHTER, OJSC GEDEON RICHTER, OJSC Hungary

Manufacturer: & nbsp

GEDEON RICHTER-RUS, CJSC Russia

GEDEON RICHTER, Ltd. Hungary

Representation: & nbspGEDEON RICHTER OJSC GEDEON RICHTER OJSC Hungary

Information update date: & nbsp26.12.2017

Illustrated instructions

Instructions

Kwamatel® mini (Quamatel® mini)