Included in the formulation
АТХ:N.05.C.X Sleeping and sedative drugs (excluding barbiturates) in combination with other drugs
Pharmacodynamics:Phytopreparation in the form of lily of the valley herb tincture in the concentration of 100 g / l and herb of the motherwort 100 g / l. It has a blocking effect on the transport sodium / potassium ATP phase, after which the content of sodium ions in cardiomyocytes increases, calcium channels open, calcium enters the cells. An increase in the concentration of sodium accelerates the release of calcium from the sarcoplasmic reticulum and increases its content in the cell, thereby inhibiting the troponin complex, which inhibits the interaction of actin and myosin. The strength and speed of contraction of the cardiac muscle increases regardless of the preliminary stretching of the myocardium - the systole is shortened, becoming energetically economical. Increased myocardial contractility contributes to an increase in the shock volume of the blood.
Reduction of the end systolic and diastolic volumes of the heart together with an increase in myocardial tone reduces the size of the heart, reducing the need for myocardium in oxygen.
Carries out a negative chronotropic action, reduces the increased sympathetic activity, increasing the sensitivity of cardiopulmonary baroreceptors. Strengthening the activity of the vagus nerve, has an antiarrhythmic effect due to the elongation of the refractory period and a decrease in the rate of impulses through the atrioventricular node. The effect is improved by direct action on atrioventricular node and sympatholytic effects.
The herb of the motherwort has a mild sedative effect.
Pharmacokinetics:Binding to blood proteins up to 2-3%. It is not subjected to biotransformation, it is excreted by the kidneys unchanged.
Indications:It is used in complex therapy for sleep disorders, increased nervous excitability, mild heart failure, in the initial stage of arterial hypertension.
XVIII.R40-R46.R45.1 Anxiety and Excitement
IX.I10-I15.I15 Secondary Hypertension
IX.I10-I15.I10 Essential [primary] hypertension
IX.I30-I52.I50 Heart failure
V.F50-F59.F51.0 Insomnia inorganic etiology
Contraindications:- Cardiosclerosis.
- Myocarditis.
- Endocarditis.
- A common atherosclerosis.
- Individual intolerance.
- Children under 12 years.
Carefully:Liver diseases, alcoholism, craniocerebral trauma, brain diseases.
Pregnancy and lactation:Recommendations for FDA - Category C. Penetrates through the placenta and enters the breast milk. During pregnancy and during lactation, the use is contraindicated.
Dosing and Administration:Inside for 15-20 drops 2-3 times a day. The highest daily dose: 60 drops.
The highest single dose: 20 drops.
Side effects:Nausea, vomiting, arrhythmia.
Allergic reactions.
Overdose:Increased side effects.
Treatment - lowering the dose of the drug.
Interaction:Catecholamines, diuretics, calcium preparations - contribute to the risk of glycoside intoxication.
Spironolactone, verapamil, nifedipine, quinidine - Increase the concentration of glycosides in blood plasma.
Reception antacids reduces absorption of the drug.
Inotropic effect increases with simultaneous application with riboflavin, thiamine chloride, pyridoxine, folic acid, methionine, inosine, phosphaden, anabolic steroids.
Special instructions:The likelihood of developing intoxication is increased in patients with impaired electrolyte metabolism (hypokalemia, hypernatremia, hypercalcemia), with obesity and in elderly patients.
The composition of the drug contains at least 64% of ethyl alcohol.
When using the drug should be careful when dealing with potentially dangerous activities that require concentration and speed of psychomotor reactions (including driving, working with moving mechanisms).