Laiys Grass (LAIS Grass)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbspTablets are sublingual.
Composition:

Ingredients name

amount

300 AE *

1000 AE *

Active substance

Monomeric allergoid from a mixture of grasses in

The quantity equivalent to 300 AE

Quantity equivalent to 1000 AE

equal proportions: bukharnik woolly, timothy grass; bluegrass



meadow



Excipients (mg)

Silicon dioxide

1

1

colloidal water



Magnesium stearate

2

2

Cellulose,

37

37

microcrystalline



Lactose Monohydrate

Prior to the weight of the tablet, 110 mg

Prior to the weight of the tablet, 110 mg

* The allergenic unit (AE) is the unit of standardization of the firm Lofarma. One AE is equivalent to a 1/40 provoking dose of the corresponding unmodified allergen assessed by the nasal provoking test in volunteers sensitized to the pollen of the above herbs and suffering from allergic rhinitis.
Description:Round-convex smooth homogeneous white tablets, 7 mm in diameter. With a notch on one side and engraved with a digit on the other side: 300 AE - with the number "3", 1000 AE - with the number "4".

ATX: & nbsp
  • Allergens of grass pollen
    • Pharmacodynamics:BIOLOGICAL AND IMMUNOLOGICAL PROPERTIES: mixture: bukharnik woolly (Holcus lanatus) 33%, timothy grass (Phleum pratense) 33%, meadow grass (Roa pratensis 33%), are carbamylated, to weaken their ability to react with IgE antibodies.This suppresses their allergenic activity and, therefore, provides a favorable immunotherapeutic effect and simultaneously reduces the risk of local and systemic side effects, in contrast to natural allergens.
    Indications:Sublingual allergen-specific immunotherapy (ASIT) of patients with increased sensitivity to a mixture of cereal grasses (bukharnik woolly, timothy grass, meadow grassland), with confirmed presence of an allergic reaction. Assign for allergic diseases associated with allergies to herbal pollen, for example: bronchial asthma, rhinitis and rhinoconjunctivitis.
    Contraindications:
    - hypersensitivity to the components of the drug.

    - severe systemic diseases (malignant neoplasms, autoimmune diseases, immunodeficiency, etc.)

    - chronic infections, viral infections, etc.

    - cardiovascular diseases,

    - severe pulmonary diseases (severe asthma, emphysema, bronchiectasis, etc.).

    - simultaneous therapy with beta-blockers

    - treatment of pathologies, in which the use of adrenaline is contraindicated.
    Dosing and Administration:
    PRECAUTIONARY MEASURES

    Specific immunotherapy is taken according to the individual treatment regimen. Dosages and the number of doses can be changed by the doctor according to the treatment, disease. The phase of initial therapy and treatment is described in the treatment regimen in the item "Dosage and method of administration". The proposed treatment regimens are presented only for reference.

    The patient is also recommended to consult a doctor to adjust the dose for colds with fever or respiratory tract infections. If a patient needs antiviral vaccination, immunotherapy may be suspended one week before vaccination and resumed two weeks after vaccination.

    You should avoid drinking alcohol and heavy physical activity for a few hours after taking the medication.

    The tablets should be kept under the tongue until completely dissolved (1-2 minutes), then swallowed.

    Take the pill whenever possible on an empty stomach.

    Treatment consists of two phases. Phase 1 - the phase of the maintenance dose set (initial therapy), phase number 2 - continuation of treatment with a maintenance dose (maintenance therapy)

    Initial therapy

    Treatment begins with tablets of 300 AE and continue with 1000 AE tablets according to the scheme given below. It is recommended to begin treatment 2 months before the flowering season and continue treatment during the flowering season.

    Reception scheme:

    Blister with tablets 300 AE

    day 1: 1 tablet (equivalent to 300 AE)

    day 2: 2 tablets (equiv. 600 AE)

    day 3: 3 tablets (equiv. 900 AE)

    day 4: 4 tablets (equiv. 1200 AE)

    Next week, a blister with 1000 AE tablets is used.

    After the initial phase, seasonal treatment is continued, taking 1 tablet a day at least 5 times a week (for example, Monday to Friday). Supportive therapy

    The main treatment is continued with 1000 AE tablets as described above. The proposed treatment regimens are given solely as recommendations. The scheme of reception is determined by the allergist doctor, based on observations and anamnesis. It is recommended to continue treatment for 3 to 5 years.

    Side effects:
    Since the drug is a chemically modified allergen (monomeric allergoid), undesirable effects during therapy are extremely rare. Nevertheless, the occurrence of rhinitis, skin rashes, mild dyspnea and delayed reactions in the first hours after taking the drug is not ruled out.Any local (e.g., itching of the mouth and lips), and / or systemic adverse events occurring during immunotherapy should be reported to the physician who will adjust the reception circuit to hold the drug and if necessary the appropriate antiallergic therapy according to the severity of the clinical picture. Such therapy may consist of oral and / or intramuscular administration of antihistamines, corticosteroids and β-2 adrenergic agonists or adrenaline subcutaneously.
    The patient should also inform his attending physician of any side effects that are not listed in the medication instructions.
    Interaction:Contraindicated taking the drug simultaneously with beta-blockers.
    Special instructions:

    Interruption of treatment with the drug Lais Grass

    In case of interruption of treatment for a period of up to 2 weeks, it should be resumed by taking the last well-tolerated dose. "

    If the therapy was interrupted for a period longer than 2 weeks, you should consult your doctor to adjust the dosing. The physician may deviate from these dosage regimens for clinical or therapeutic purposes.

    Pregnancy and lactation:

    Do not start specific immunotherapy during pregnancy because of the general limitations in taking medications for pregnant women.

    In case of pregnancy, consult a doctor before taking the medication.

    If the rate of immunotherapy is interrupted by the risk to the patient, the doctor should decide whether to continue or discontinue therapy after carefully weighing the risks to the patient at the time when the protective action of the immunotherapy stops.

    If you are breastfeeding, consult your doctor before taking the medication.

    Absolute contraindications to taking this medication during breastfeeding does not exist.

    Childhood: The course of immunotherapy can be started in childhood from 5 years.

    Effect on the ability to drive transp. cf. and fur:The drug can cause some fatigue in some patients. As a consequence, lowered attention can affect its ability to drive vehicles and work with mechanisms.
    Form release / dosage:
    Tablets of the sublingual 300,1000 AE


    Packaging:For 10 tablets of each concentration (300 AE and 1000 AE) in separate blisters of transparent polyvinyl chloride and aluminum foil. For 1 blister with a dosage of 300 AE and 3 blisters - 1000 AE, or 3 blisters - 1000 AE per pack of cardboard with instructions for use.
    Storage conditions:Store and transport at a temperature of no higher than 25 ° C. Keep out of the reach of children.
    Shelf life:
    3 years.

    Do not use after expiry date.
    Terms of leave from pharmacies:On prescription
    Registration number:LP-001400
    Date of registration:28.12.2011
    The owner of the registration certificate:Lofarma SpALofarma SpA Italy
    Manufacturer: & nbsp
    Representation: & nbspTD ALLERGEN COMPANY JSCTD ALLERGEN COMPANY JSCRussia
    Information update date: & nbsp13.03.2016
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