Frequency determination: very often (> 1/10), often (> 1/100 to <1/10), sometimes (> 1/1000 to <1/100) rarely (> 1 / 10,000 to <1 / 1000), very rarely (<1/10000).
On the part of the hematopoiesis system: very often - leukopenia (reversible if the drug is stopped on time), thrombocytopenia, lymphopenia, neutropenia, a decrease in hemoglobin; extremely rare - irreversible oppression of bone marrow function.
From the gastrointestinal tract: often - nausea, vomiting, diarrhea, ulceration of the oral mucosa; rarely - hepatotoxic effect of toxic-allergic genesis (hepatonecrosis or cirrhosis, cholestasis, jaundice).
From the respiratory system: very rarely - interstitial lung fibrosis (with prolonged use of chlorambucil), interstitial pneumonia.
Allergic reactions: sometimes - a skin rash; rarely - urtikaropodobnaya rash, angioedema; extremely rarely - multiforme erythema exudative (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome).
From the nervous system: often - convulsions in children with nephrotic syndrome; rarely - local and / or generalized seizures in children and adults receiving chlorambucil in therapeutic doses daily or courses of high-dose pulse therapy; very rarely - uncertainty when walking, tremor, muscle twitching, peripheral neuropathy, paresis, agitation, confusion, marked weakness, anxiety, hallucinations.
From the urinary system: extremely rarely - aseptic cystitis.
Other: hyperuricemia or nephropathy due to increased uric acid formation (the result of rapid cell decay), menstrual irregularity, secondary amenorrhea, azoospermia, secondary malignancy