Lomexin® - a broad-spectrum antifungal agent for topical application in gynecology. Fenticonazole (active ingredient of Lomexin®) is a synthetic derivative of imidazole (its racemic mixture in the form of a nitric acid salt of fenticonazole). Has a local fungicidal and fungistatic effect. It also has antibacterial and anti-inflammatory action.
The mechanism of action is to inhibit the synthesis of ergosterol, which regulates the permeability of the fungal cell membrane. Active for yeast fungi Candida spp. (including Candida albicans) and Gram-positive bacteria (Staphylococcus aureus, Streptococcus spp.), as well as in relation to Trichomonas vaginalis.
Unlike other known azole compounds (in particular, econazole, miconazole and ketoconazole) fenticonazole inhibits biosynthesis of proteases Candida spp. At concentrations below the minimum inhibitory concentration, 0.25 to 16 μg / ml /. This action does not depend on the magnitude of antimycotic activity and is due to the inhibition of one of the stages of the formation of proteolytic enzymes yeast-like mushrooms.