Lorinden® A (Lorinden® A)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceSalicylic acid + FlumethasoneSalicylic acid + Flumethasone
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  • Lorinden® A
    ointment externally 
    VALEANT, LLC     Russia
    • Dosage form: & nbspointment for external use
    Composition:

    1 g of the preparation contains:

    Active substances: flumethasone pivalate - 0.20 mg, salicylic acid - 30.0 mg.

    Excipients: propylene glycol 50.0 mg, lanolin 50.0 mg, petrolatum up to 1.0 g.

    Description:White with a light yellow shade of fatty, soft mass.
    Pharmacotherapeutic group:Glucocorticosteroid for topical application + keratolytic agent
    ATX: & nbsp

    D.07.X.B.01   Flumethasone in combination with other drugs

    Pharmacodynamics:

    Combination drug for external use. Flumethasone - synthetic glucocorticosteroid (GCS), has anti-inflammatory, anti-edematous, antiallergic, antipruritic effect. Inhibits the activity of phospholipase A2, which leads to suppression of the synthesis of prostaglandins and leukotrienes, inhibits the release of inflammatory mediators. It inhibits the migration of leukocytes and lymphocytes to the inflammatory focus, prevents the accumulation of neutrophils, which leads to a decrease in inflammatory exudate, production of cytokines and inhibition of migration of macrophages, in turn,leading to a decrease in infiltration and granulation, inhibits the proteolytic activity of tissue kinin, inhibits the growth of fibroblasts, prevents the development of connective tissue in the focus of inflammation.

    Reduces the manifestations of hypersensitivity reactions, proliferative and exudative processes occurring in connective tissue in the inflammatory focus, reduces hyperemia.

    Salicylic acid - non-steroidal anti-inflammatory drug (NSAID), exhibits a moderate keratolytic property, promotes the penetration of flumethasone into the skin.

    Pharmacokinetics:

    Due to keratolytic action of salicylic acid flumethasone easily penetrates into the stratum corneum of the epidermis, where cumulates. Flumethasone practically not metabolized in the skin. In a small amount can enter the body with external application and have a systemic effect. After a slight absorption in the body is metabolized mainly in the liver. It is excreted through the kidneys and, to a lesser extent, with bile in the form of compounds with glucuronic acid, and also in small amounts in unchanged form.

    Salicylic acid when applied to the skin is not absorbed, does not enter the systemic circulation.

    Indications:Acute and chronic dermatoses that occur with keratinization of the skin: atopic dermatitis, diffuse neurodermatitis, Vidal's chronic lien, various forms of subacute and chronic eczema (especially horny), hyperkeratosis (eg ichthyosis), psoriasis, seborrhea, red flat lichen, red warty lichen; nodular prurigo with severe lichenification, photodermatitis, erythema multiforme; discoid lupus erythematosus, insect bites.
    Contraindications:

    Bacterial, viral (including chicken pox and shingles), fungal skin diseases, skin tuberculosis, skin manifestations of syphilis, skin tumors, precancerous skin diseases, vulgar and rosacea, trophic ulcers of the shins associated with varicose veins; acute wetting and subacute exudative stages of skin diseases. Hypersensitivity to the components of the drug.

    I trimester of pregnancy, children under 2 years.

    Carefully:Elderly, persons with atrophic skin changes.
    Pregnancy and lactation:With extreme caution should be used in pregnant women in the II and III trimester - as an exception and on small body surfaces, only if the expected benefit for the mother exceeds the possible risk to the fetus. Do not administer in the first trimester of pregnancy. Take special care when prescribing to nursing mothers. Use in exceptional cases, briefly, in limited areas of the skin, before the drug is not recommended to apply to the skin of the mammary glands.
    Dosing and Administration:Outwardly. A thin layer of ointment is applied to the damaged skin areas 2-3 times a day, and after the acute inflammation is removed - 1-2 times a day. After complete disappearance of the symptoms of the disease, treatment is carried out for another 3-4 days. In chronic skin lesions, treatment should not last more than 3 weeks. When treating lesions on dry and defatted skin areas, the ointment can be used as an occlusive dressing, which should be changed every 24-48 hours; the degree of moistening can be controlled by the thickness of the applied layer, in accordance with the therapeutic requirements specific to each individual case.
    Side effects:

    Burning, itching, dry skin. With long-term use - skin atrophy, local hirsutism, telangiectasia, purpura, steroid acne, perioral dermatitis, pigmentation disorders. With long-term use and / or application to large areas of the skin and with the use of occlusive dressings, systemic side effects characteristic of glucocorticosteroids are possible: suppression of adrenal cortex function, weight gain, osteoporosis, increased blood pressure, swelling, ulceration of the gastrointestinal mucosa, exacerbation of hidden foci of infection, hyperkalemia, agitation, insomnia, menstrual cycle disorders.

    In children (side effects are additional to side effects in adults) - oppression of the hypothalamic-pituitary-adrenal system, Itenko-Cushing syndrome, growth retardation, lag in weight gain, increased intracranial pressure (flumethasone).

    Overdose:With prolonged use in large areas of the skin, symptoms of hypercorticism may occur, which requires a gradual discontinuation of the drug under the supervision of a physician. There is no evidence of an overdose of salicylic acid.
    Interaction:Do not vaccinate and immunize, due to the immunosuppressive effect of the drug. Do not administer in combination with other drugs for external use. In the case of resorption of the drug into the total bloodstream, glucocorticosteroid reduces the action of insulin, oral hypoglycemic agents, antihypertensive drugs, anticoagulants, reduces the concentration of praziquantel in the blood serum. With the simultaneous use of the drug with androgens, estrogens, oral contraceptives, anabolic steroids, antipsychotic drugs, carbutamide, azathioprine, holinoblockers, antihistamines, tricyclic antidepressants, nitrates, diuretics and cardiac glycosides, the risk of side effects of glucocorticosteroids increases.
    Special instructions:

    Do not apply the product to the skin of the face. Do not apply for extended periods on large areas of the skin. Avoid getting ointment in the eyes. Do not use in the periorbital area (do not apply to the skin of the eyelids because of the risk of cataracts or glaucoma). With prolonged use of glucocorticosteroids in large areas of the skin, the incidence of side effects increases.

    When attaching a bacterial or fungal infection, appropriate complementary therapy should be prescribed.

    Children. Children are allowed to prescribe the drug from two years only on strict indications and under the supervision of a doctor.

    Effect on the ability to drive transp. cf. and fur:The drug does not limit the psychophysical activity, the ability to drive vehicles and maintain machinery in motion.
    Form release / dosage:
    Ointment for external use.
    Packaging:For 15 grams in aluminum tubes with a varnished inner surface. The tube is placed in a cardboard box with instructions for use.
    Storage conditions:Store at a temperature not exceeding 25 ° C. Keep out of the reach of children.
    Shelf life:
    3 years. Do not use after expiry date.
    Terms of leave from pharmacies:On prescription
    Registration number:П N011810 / 01
    Date of registration:06.08.2010 / 24.10.2013
    Expiration Date:Unlimited
    The owner of the registration certificate:VALEANT, LLC VALEANT, LLC Russia
    Manufacturer: & nbsp
    Representation: & nbspVALEANT LLC VALEANT LLC Russia
    Information update date: & nbsp19.03.2018
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