Classification of the frequency of development of side effects of the World Health Organization (WHO):
Often ≥1/10
often from ≥1 / 100 to <1/10
infrequently from ≥1 / 1000 to <1/100
rarely from ≥1 / 10000 to <1/1000
very rarely <1/10000
the frequency of the unknown can not be estimated from the available data. Undesirable reactions with the combination hydrochlorothiazide / losartan were observed earlier with and losartan and / or hydrochlorothiazide.
Postmarketing application combinations hydrochlorothiazide / losartan
Additional adverse reactions:
From the digestive system:
rarely: hepatitis.
Laboratory data:
rarely: hyperkalemia, increased activity of alanine aminotransferase (ALT).
Undesirable reactions that occurred when used in monotherapy with losartan or hydrochlorothiazide and can be used with the combination hydrochlorothiazide / losartan:
Losartan
From the hematopoiesis:
infrequently: anemia, purple Shenlaine-Henoch, ecchymosis, hemolysis;
frequency unknown: thrombocytopenia.
From the cardiovascular system:
infrequently: marked decrease in blood pressure, Orthostatic hypotension, chest pain, angina pectoris, atrioventricular blockade (AV blockade) II degree, cerebral blood flow disorder, myocardial infarction (with excessive decrease in blood pressure), a feeling of "heartbeat", arrhythmia (atrial fibrillation, sinus bradycardia, tachycardia, ventricular tachycardia, ventricular fibrillation), vasculitis.
From the sense organs:
infrequently: vertigo, tinnitus, blurred vision, burning sensation / tingling sensation in the eyes, conjunctivitis, decreased visual acuity.
From the digestive system:
often: abdominal pain, nausea, diarrhea, dyspepsia;
infrequent: constipation, pain in the teeth, dryness mucous membrane of the oral cavity, bloating stomach, gastritis, vomiting, obstruction intestines;
frequency unknown: pancreatitis, abnormal liver function.
Allergic reactions:
rarely: hypersensitivity: anaphylactic reactions, angioedema, including edema larynx and pharynx causing obstruction of the airways and / or swelling of the face, lips, throat and / or tongue; the some angioedema patients edema was also noted in a history of treatment with other drugs, including ACE inhibitors.
From the side of the locomotor system apparatus:
often: muscle cramps, back pain, pain in the legs, myalgia;
infrequently: pain in the hands, swelling of the joints, pain in the knees, musculoskeletal pain, pain in the shoulders, stiffness, arthralgia, arthritis, coxalgia, fibromyalgia, muscle weakness;
frequency unknown: rhabdomyolysis.
From the nervous system:
often: headache, dizziness, insomnia;
infrequently: nervousness, paresthesia,peripheral neuropathy, tremor, migraine, fainting, anxiety, anxiety disorder (excessive, uncontrolled and often irrational anxiety about everyday events), panic disorder panic attacks), confusion, depression, nightmarish dreams, sleep disturbance, drowsiness, memory impairment.
From the genitourinary system: often: renal dysfunction, kidney failure; infrequently: nocturia, frequent urination, urinary tract infections.
On the part of the reproductive system:
infrequently: decreased libido, erectile dysfunction / impotence.
From the respiratory system: often: cough, upper respiratory tract infections, nasal congestion, sinusitis, violation of upper airway patency;
infrequently: a feeling of discomfort in the pharynx, pharyngitis, laryngitis, dyspnea, bronchitis, epistaxis, rhinitis, congestion in the respiratory tract.
From the skin:
infrequently: alopecia, dermatitis, dry skin, erythema, sensation of "hot flashes" blood to the skin of the face, photosensitivity, itchy skin, skin rash, urticaria, increased sweating.
Other:
often: asthenia, increased fatigue, anorexia;
infrequently: swelling of the face, swelling, fever; frequency unknown: influenza-like symptoms, malaise.
Laboratory indicators:
often: hyperkalemia, insignificant reduction of hemoglobin and hematocrit, hypoglycemia;
infrequently: a slight increase Serum concentrations of urea and creatinine;
very rarely: increased activity "hepatic" enzymes and bilirubin concentration in plasma blood;
frequency unknown: hyponatremia.
Hydrochlorothiazide
From the hematopoiesis:
infrequently: agranulocytosis, aplastic anemia, hemolytic anemia, leukopenia, purpura, thrombocytopenia.
Allergic reactions:
rarely: anaphylactic reaction.
From the side of metabolism:
infrequently: anorexia, hyperglycemia, hyperuricemia, hypokalemia, hyponatremia.
From the nervous system:
often: headache;
infrequently: insomnia.
From the sense organs:
infrequently: transitory violation visual perception, xantopsy;
frequency unknown: acute myopia and acute closed angle glaucoma.
From the side of cardiovascular system:
infrequently: necrotizing angiitis (vasculitis, cutaneous vasculitis).
From the respiratory system:
infrequently: respiratory distress syndrome, including pneumonitis and pulmonary edema.
From the digestive system:
infrequently: sialadenitis, spasm, irritation stomach, nausea, vomiting, diarrhea, constipation, jaundice (intrahepatic cholestasis), pancreatitis.
From the skin:
infrequently: photosensitivity, urticaria, toxic epidermal necrolysis.
From the side of the locomotor system apparatus:
infrequently: muscle cramps.
From the genitourinary system:
infrequently: glucosuria, interstitial
nephritis. impaired renal function, renal insufficiency.
Other:
infrequently: fever, dizziness.