Magnelis® B6 (Magnelis® B6)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbspcoated tablets
Composition:

For one tablet

Active substances

Magnesium lactate dihydrate 470 mg

in terms of magnesium (Mg2+) - 48 mg

Pyridoxine hydrochloride - 5 mg

Excipients: sucrose (white sugar) - 27.4 mg, kaolin 41.0 mg, acacia gum (gum arabic) 25.0 mg, kollidone® SR [polyvinyl acetate 80%, povidone (K 30) 19%, sodium laurelsulphate 0.8%, silicon dioxide 0.2%] 34.0 mg, magnesium stearate 6.8 mg, carmellose sodium 34.0 mg, talc is 6.8 mg.

Shell composition: sucrose (white sugar) 166.7 mg, kaolin 54.0 mg, gelatin 0.9 mg, acacia gum (4.0 g), beeswax 0.4 mg, titanium dioxide 9, 0 mg, talc - 15.0 mg.

Description:

Round biconvex tablets covered with a white coating with a grayish shade of color. On a cross-section the rough kernel of white color with impregnations from white with a creamy shade to light yellow color.

Pharmacotherapeutic group:Magnesium preparation
ATX: & nbsp
  • Preparations of magnesium
    • Pharmacodynamics:

    Replenishes the deficiency of magnesium.

    Magnesium is a vital element that is found in all tissues of the body and is necessary for the normal functioning of cells. Participates in most metabolic reactions, in the regulation of nerve impulse transmission and in muscle contraction, has antispasmodic, antiarrhythmic and antiaggregant effects.

    The body gets magnesium along with the food.The lack of magnesium in the body can be observed with a violation of diet (diet) or with increasing demand for magnesium (with increased physical and mental stress, stress, pregnancy, the use of diuretics).

    Pyridoxine (vitamin B6) is involved in many metabolic processes, in the regulation of the metabolism of the nervous system. Vitamin B6 improves the absorption of magnesium from the gastrointestinal tract and its penetration into the cells.

    Magnesium content in serum:

    - from 12 to 17 mg / l (0.5-07 mmol / l) indicates a moderate magnesium deficiency;

    - below 12 mg / L (0.5 mmol / L) indicates a severe magnesium deficiency.

    Pharmacokinetics:

    The absorption of magnesium in the gastrointestinal tract is 50% of the ingested dose. It is excreted mainly through the kidneys. In the kidneys, after the glomerular filtration of 70% of the magnesium present in the plasma, it is reabsorbed by the renal tubules in a proportion of 95-97%.

    Indications:

    The established magnesium deficiency, isolated or associated with other deficient conditions, accompanied by such symptoms as: increased irritability; minor sleep disorders; gastrointestinal spasms; cardiopalmus; increased fatigue; pain and muscle spasms, a tingling sensation in the muscles.

    Contraindications:

    Hypersensitivity to the drug components, marked renal failure (creatinine clearance less than 30 ml / min), sugarase / isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption.

    Children under 6 years.

    Carefully:

    With moderate renal failure, as there is a risk of hypermagnesemia.

    Pregnancy and lactation:

    Pregnancy

    Clinical experience has not revealed fetotoxic or defective fetal developmental effects. Magnelis® AT6 can be used during pregnancy only as directed by the doctor.

    Breastfeeding period

    Magnesium penetrates into breast milk.

    Avoid the use of the drug during breastfeeding.

    Dosing and Administration:

    Before taking the drug, you should consult your doctor.

    Adults are recommended to take 6-8 tablets per day.

    Children older than 6 years (body weight over 20 kg) 4-6 tablets per day.

    The daily dose should be divided into 2-3 doses, taken with food, washed down with a glass of water.

    Treatment should be discontinued after the normalization of the magnesium concentration in the blood.

    Side effects:

    On the part of the digestive system: abdominal pain, constipation, nausea, vomiting, flatulence.

    Allergic reactions: atAllergic reactions to the drug components are possible.

    Overdose:

    With normal kidney function, oral magnesium intake does not cause toxic reactions. Magnesium poisoning can develop with kidney failure. Toxic effects mainly depend on the magnesium content in the blood serum.

    Symptoms of overdose: drop in arterial pressure, nausea, vomiting, slowing of reflexes, anuria, respiratory depression, coma, cardiac arrest.

    Treatment: rehydration, forced diuresis. With renal failure, hemodialysis or peritoneal dialysis is necessary.

    Interaction:

    - The simultaneous use of drugs containing phosphates or calcium salts can significantly reduce the absorption of magnesium in the gastrointestinal tract.

    - Magnesium preparations reduce the absorption of tetracycline, it is recommended to divide the reception of these drugs with a three-hour interval.

    - Magnesium weakens the effect of oral thrombolytic agents, reduces the absorption of iron.

    - Vitamin B6 inhibits the activity of levodopa.

    Special instructions:

    Information for patients with diabetes mellitus: The tablets contain sucrose as an auxiliary.

    In case of concomitant calcium deficiency, magnesium deficiency should be eliminated before calcium intake is started.

    With frequent use of laxatives, alcohol, intense physical and mental stress, the need for magnesium increases, which can lead to to the development of magnesium deficiency in the body.

    Effect on the ability to drive transp. cf. and fur:

    The drug does not adversely affect the driving of motor vehicles and the performance of potentially hazardous activities requiring increased concentration of attention and speed of psychomotor reactions.

    Form release / dosage:

    The tablets covered with a cover.

    Packaging:

    For 60 or 90 tablets in cans of polymeric, made of low-density polyethylene.

    Banks are capped with screw caps, made of high pressure polyethylene or low pressure polyethylene.

    Each jar is wrapped with a polyvinyl chloride shrink tube. 10 tablets per contour cell pack.

    Each jar or 3 or 5 contour squares is placed in a pack of cardboard together with an instruction for use.

    Storage conditions:

    At a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    3 years.

    Do not use after expiry date.

    Terms of leave from pharmacies:Without recipe
    Registration number:LSR-008492/08
    Date of registration:24.10.2008 / 19.01.2018
    Expiration Date:Unlimited
    The owner of the registration certificate:OTISIFARM, OJSC OTISIFARM, OJSC Russia
    Manufacturer: & nbsp
    Representation: & nbspPHARMSTANDART-Ufa-VITA, JSCPHARMSTANDART-Ufa-VITA, JSC
    Information update date: & nbsp22.03.2018
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