Magnesium plus (Magnesium plus)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
Read on
Similar drugsTo uncover
Dosage form: & nbsptablets, effervescent
Composition:

For one tablet:

Active substances:

Magnesium lactate

200.0 mg

Magnesium carbonate

Pyridoxine hydrochloride (Vitamin B6)

2.0 mg

Folic acid (Vitamin B9)

0,2 mg

Cyanocobalamin 0.1% (Vitamin B12 0,1%)

1,000 mg

in terms of vitamin B12

0,001 mg

Excipients: sodium hydrogen carbonate 800.0 mg, citric acid 1300.0 mg, sodium saccharinate dihydrate 10.0 mg, sorbitol 966.8 mg, macrogol 40.0 mg, lime flavor 80.0 mg.

Description:

Round, flat-cylindrical, with a beveled edge of the tablet white or white with a slightly yellowish-greenish tint of color, with a dividing strip on one side, with a weak specific odor.

Pharmacotherapeutic group:Magnesium preparation
ATX: & nbsp
  • Preparations of magnesium
    • Pharmacodynamics:

    Magnesium is a vital element. It plays an important role in the activity of the nervous system, participates in the regulation of the transmission of nerve impulses and in the contraction of muscles, in most metabolic reactions plays an important physiological role in maintaining the ion balance, participates in energy processes (ATP, a chemical energy source, can enter the formation process energy only in the form of a magnesium salt).

    Vitamin B6 plays an important role in the metabolism, helps maintain the structure and function of bones, teeth, gums; has an effect on erythropoiesis,contributes to the normal functioning of the nervous system and supplements the effect of magnesium.

    Vitamin B12 and folic acid participate in many enzymatic reactions and have a beneficial effect on the nervous and hematopoietic systems.

    Pharmacokinetics:

    Suction magnesium in the gastrointestinal tract is no more than 50% of the dose taken. In the body, 99% of magnesium is found inside cells. Approximately 2/3 of intracellular magnesium is distributed in the bone tissue, and 1/3 is in the smooth and striated muscle tissue. It is excreted in the urine. Glomerular filtration is 70% of the plasma, tubular reabsorption - 95-97%. With urine, at least 1/3 of the intake of magnesium is taken.

    Pyridoxine hydrochloride absorbed rapidly throughout the small intestine, a larger amount is absorbed in the jejunum. Metabolised in the liver with the formation of pharmacologically active metabolites (pyridoxal phosphate and pyridoxamine phosphate). Pyridoxal phosphate with plasma proteins binds to 90%. It penetrates well into all tissues; accumulates mainly in the liver, less - in the muscles and the central nervous system. Penetrates through the placenta, is secreted with breast milk. T1/2 - 15-20 days.It is excreted by the kidneys (with iv in the introduction - with bile 2%), as well as during hemodialysis. About 8-10% the drug is excreted in the urine unchanged.

    Folic acid well and fully absorbed in the gastrointestinal tract, mainly in the upper parts of the duodenum. Intensively binds to plasma proteins. Penetrates through the blood-brain barrier, the placenta and into breast milk. The time to reach the maximum concentration is 60 minutes. Deposited and is metabolized in the liver to form tetrahydrofolic acid (in the presence of ascorbic acid under the action of dihydrofolate reductase). It is excreted by the kidneys, mainly in the form of metabolites.

    Cyanocobalamin absorbed in the thin (partly in the thick) intestine, connecting with the internal factor, becomes protected from the microflora of the intestine. In blood Cyanocobalamin with the trans-balanamines I and II, with which it is transported to the tissues. Deposited Cyanocobalamin mainly in the liver, is excreted from the liver with bile in the intestine, from which it is again absorbed. Eliminated from the body by the kidneys. After oral administration up to 2 mg, 30-97% is absorbed, the absorption of the drug (depending on the internal absorption factor) after taking in a dose of more than 2 mg is markedly reduced. The connection with plasma proteins is 90%. FROMmOh after oral administration is achieved after 6-14 hours. T1/2 in the liver - 500 days. It is excreted at normal kidney function - 7-10% by kidneys, about 50% - with calves; with a reduced renal function - 0-7% kidney, 70-100% - with a caloric mass. Penetrates through the placental barrier, into breast milk.

    Indications:

    Prevention of magnesium deficiency and related conditions: neuromuscular disorders (muscle weakness, trembling, spasms, convulsions), mental disorders (insomnia, irritability, anxiety), cardiac rhythm and activity of the gastrointestinal tract (pain, spasms, bloating intestines).

    Contraindications:

    Severe renal failure (creatinine clearance less than 30 ml / min), hypersensitivity to the components of the drug, children under 6 years.

    Carefully:

    With moderate violations of kidney function because of the risk of hypermagnesemia.

    Pregnancy and lactation:

    During pregnancy and lactation, the use of the drug is possible with caution and under indications, because at this time the need for magnesium is significantly increased. If its content is not balanced, it can lead to serious complications, incl. miscarriage.

    Magnesium penetrates into breast milk, so you should avoid using the drug during breastfeeding.

    Dosing and Administration:

    Inside.

    Adults and children from 12 years: for 1-2 tablets.

    Children from 6 to 12 years: 1/2 tablets.

    Take in the morning, pre-dissolved in a glass of water.

    Side effects:

    Allergic reactions, dyspeptic disorders (diarrhea, abdominal pain).

    When used in high doses, it is possible to develop hypermagnesia.

    Overdose:

    Symptoms of overdose: drop in arterial pressure, nausea, vomiting, slowing of reflexes, respiratory depression, coma, cardiac arrest and paralysis of the heart, anuria.

    Treatment: rehydration, forced diuresis. With renal failure, hemodialysis or peritoneal dialysis is necessary.
    Interaction:

    Phosphates and calcium salts reduce the absorption of magnesium in the gastrointestinal tract.

    Magnesium preparations reduce the absorption of tetracycline, it is recommended to do an interval of 3 hours before using MAGNESIUM PLUS.

    Pyridoxine can weaken the action of levodopa.

    Special instructions:

    In the case of concomitant calcium deficiency, magnesium deficiency should be eliminated before the introduction of additional calcium intake.

    With frequent use of laxatives, alcohol, increased physical and mental stress, the need for magnesium increases.

    Effect on the ability to drive transp. cf. and fur:

    The drug does not affect the ability to drive vehicles and work with potentially dangerous mechanisms.

    Form release / dosage:The tablets are effervescent.
    Packaging:

    For 10, 12 tablets in a plastic case.

    For 1 pencil case in a cardboard box or in a pack-envelope with a device for hanging with instructions for use.

    Storage conditions:

    At a temperature of no higher than 25 ° C.

    Keep out of the reach of children.
    Shelf life:

    3 years.

    Do not use after the expiration date.

    Terms of leave from pharmacies:Without recipe
    Registration number:П N010435
    Date of registration:04.08.2011 / 30.04.2014
    Expiration Date:Unlimited
    The owner of the registration certificate:VALEANT, LLC VALEANT, LLC Russia
    Manufacturer: & nbsp
    Representation: & nbspVALEANT LLC VALEANT LLC Russia
    Information update date: & nbsp22.03.2018
    Illustrated instructions
      Instructions
      Up