Mardil Zink - instructions for use, dose, side effects, contraindications

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Dosage form: & nbsptopical solution

Composition:

In 1 ml:

Active substance: Mardil Zink semi-finished solution (1.5% zinc chloropropionate solution in 2-chloropropionic acid) 0.3 ml.

Excipient: water purified to 1 ml.

Description:Transparent liquid is colorless or slightly yellow with a specific odor.

Pharmacotherapeutic group:Local necrotizing agent

ATX: & nbsp

Other drugs for use in gynecology

Pharmacodynamics:

Mardil Zinc^® is a 30% aqueous solution of zinc chloropropionate and 2-chloropropionic acid. With topical application on the affected parts of the mucous membrane of Mardil Zinc^® is able to interrupt the growth and vital activity of pathologically altered cells and tissues, including benign neoplasms of the mucosa, through angiocoagulation, dehydration and devitalization. With topical application to the affected areas of the mucosa, the drug leads to fixation followed by necrotic tissue pathology. The direct effect of the drug is expressed in the discoloration of the mucous membrane with the appearance of a characteristic pale gray shade.

When the preparation is applied to the ectopic cylindrical epithelium (cervical ectopia and transformation zone), coagulation and devitalization take place. At the same time intact multilayered flat epithelium of the vaginal part of the cervix and mucous membranesheath of the vagina, which is more resistant to the effects of the drug Mardil Zinc^®, remains practically intact. Healing occurs without complications in the absence of secondary infection, does not leave scarring, deformations of adjacent tissues and violations of organs.

Pharmacokinetics:When applied to the affected areas of the mucous membrane of Mardil Zinc^® It is not absorbed and has no systemic effect on the body.

Indications:Mardil Zinc^®It is intended for topical treatment of benign mucous membrane formations of the vagina and cervix: anogenital warts, cervical ectopy.

Contraindications:Malignant neoplasms of the cervix, vagina and anogenital zones, cervical intraepithelial neoplasia (CIN), pregnancy, lactation, hypersensitivity to the components of the drug, children under 18 years of age.

Dosing and Administration:

Locally.

Treatment of ectopia. Before the procedure is mandatory oncocytological examination of smears-prints. The procedure should be performed by a specialist gynecologist or dermatovenereologist using a colposcope.The drug should be applied only to the altered tissue, avoiding the solution on a healthy mucous membrane. Before the treatment procedure it is necessary to prepare the vagina and cervix by removing the vaginal slime with a cotton swab. The application is carried out once by a universal probe or an applicator. The effect is manifested as the appearance of a whitish-yellow color of the tissue. In the following, a decrease in the scab and its rejection is noted. The duration of epithelialization depends on the size of the ectopia and can range from 2 to 6 weeks. The amount of the drug applied depends on the area of the lesion and can vary from 0.02 to 0.2 ml.

The maximum daily dose should not exceed 0.2 ml.

Treatment of anogenital warts. Treatment is carried out on an outpatient basis under the supervision of a physician. The procedure does not require anesthesia. The drug is applied with a probe a universal or an applicator. After applying the drug, the color of the tissues changes to a whitish-gray color. The number of applications and the volume of the drug applied depend on the size of the formation and the area of the mucosal lesion and can be 0.02 ml to 0.2 ml.

The maximum daily dose should not exceed 0.2 ml.

In the presence of extensive lesions, treatment with the drug should be carried out in several stages with an interval of at least 24 hours. During each procedure, no more than 2-3 lesions with a total area of up to 3 cm2 can be treated. When applying the drug Mardil Zinc^® there is a small swelling of the mucosa. Within 2-3 days after using the drug, rejection of necrotic tissues takes place. Complete regeneration is observed for 10-14 days. With large anogenital warts in case of incomplete necrosis, it is possible to re-apply the drug after 5-7 days.

Side effects:Possible short-term itching and burning, swelling of the tissue. Allergic reactions with individual sensitivity to the components of the drug.

Overdose:If the product is used incorrectly, erosion can occur. To prevent acid burns, the preparation should be rinsed with running water. Healing can occur independently without the use of additional drugs or with the use of wound healing drugs.

Interaction:Interaction of the drug Mardil Zinc^®with other drugs of local action is not established.

Special instructions:

Handle with care.

Before opening the vial should be shaken and move the solution, which got in the top of the bottle, to its bottom. The opened vial should be in a strictly vertical position.

Mardil Zinc^® contains an acid in its composition. Avoid getting the product on healthy skin or mucous membranes. If there was an accidental ingestion of the drug Mardil Zinc^® on a healthy skin or mucous, it is necessary to remove the drug as quickly as possible with a cotton swab moistened with water. If accidental ingestion occurs in the eyes, rinse immediately with plenty of water and 1% sodium hydrogen carbonate solution, and then consult a doctor.

After carrying out medical manipulations, it is possible to conduct hygienic procedures. However, you should avoid visiting the pool, baths, saunas, swimming in open water, taking baths.

Disposal of used bottles: Before discarding the vial, the rests of the drug should be washed off in running water. Empty vial can be thrown into the garbage container.

Form release / dosage:Solution for topical application.

Packaging:1 ml of solution in a bottle of light-protective glass, sealed with a rubber lid with a combined aluminum-plastic cap. One bottle is placed in a container of foam and together with instructions for use in a cardboard pack.

Storage conditions:

In the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years.

Do not use the medicinal product after the expiration date indicated on the package.

Terms of leave from pharmacies:On prescription

Registration number:LSR-005234/09

Date of registration:30.06.2009 / 28.05.2010

Expiration Date:Unlimited

The owner of the registration certificate:OXYGON, LTD. OXYGON, LTD. Russia

Manufacturer: & nbsp

FARMTSENTR VILAR, ZAO Russia

Information update date: & nbsp27.03.2018

Illustrated instructions

Instructions

Mardil Zinc® (Mardil Zink)