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Dosage form: & nbspfilm-coated tablets
Composition:

One tablet contains 60 mg of Amur wood extract maakia (with a content of a sum of stilbenes and isoflavones of not less than 19.8%) as an active substance, Excipients: dextrose monohydrate 16.43 mg, potato starch 63.97 mg, magnesium stearate 2.08 mg, microcrystalline cellulose 65.52 mg; membrane film - hypromellose 6.50 mg, tropeolin-O 20 μg, silicon dioxide colloid 650 μg, talc 1.30 mg, titanium dioxide 1.53 mg.

Description:Round, biconvex tablets, covered with a film coating of yellow color.
Pharmacotherapeutic group:Hepatoprotective agent of plant origin
ATX: & nbsp
  • Preparations for the treatment of liver diseases
  • Pharmacodynamics:

    The therapeutic effect of Maksar® is due to a complex of biologically active substances of dry extract from the wood of Maacia Amur, the most important of which are isoflavones (formononetin, genistein, retuzin, maakiasin) and stilbenes (resveratrol and piceatanol).

    Maxar® has a hepatoprotective, choleretic effect, it helps normalize the impaired liver histoarchitectonics, while reducing the number of necrotic hepatocytes, eliminating the protein and fatty degeneration of the liver parenchyma. Maxar® inhibits the reactions of lipid peroxidation; improves the respiratory function of mitochondria; stabilizes the membrane of lysosomes and inhibits the release of necrosogenic hydrolases,including phospholipase A; stimulates the processes of oxidation and conjugation of xenobiotics, glucuronidation of bilirubin; increases the excretory function of the liver; reduces hyperfermentation (aminotransferase, lactate dehydrogenase, alkaline phosphatase). With chronic hepatitis, the drug, suppressing the lipid peroxidation-stimulated synthesis of collagen and glucosaminoglycans, inhibits the formation of fibrosis inside the hepatic lobules, providing anti- necrotic and anti-inflammatory effects.

    Maxar® has a choleretic effect: increases the rate of bile secretion and excretion of fatty acids, bilirubin and cholesterol into it.

    Pharmacokinetics:Not studied.
    Indications:

    At adults at treatment of an acute and chronic hepatitis, a cirrhosis of a liver, a fatty hepatosis, at a syndrome of a cholestasis.

    Contraindications:Hypersensitivity to the components of the drug; pregnancy, the period of breastfeeding, age to 18 years, cholelithiasis (exacerbation period).
    Pregnancy and lactation:Contraindicated in pregnancy and lactation.
    Dosing and Administration:

    Inside, 1 tablet 3 times a day for 30-40 minutes before meals. Duration of treatment - 4 weeks.An increase in the duration and conduct of repeated courses of treatment is possible on the recommendation of a doctor.

    Side effects:Allergic reactions are possible.
    Overdose:

    So far, no cases of overdose have been reported.

    Interaction:

    Interaction with other drugs is not described.

    Effect on the ability to drive transp. cf. and fur:The drug does not affect the ability to drive vehicles and engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
    Form release / dosage:

    Tablets of 60 mg.

    Packaging:

    50, 100 tablets in cans of orange glass or polymeric; banks along with instructions for use in a pack of cardboard.

    10 tablets per contour cell packaging made of polyvinylchloride film and aluminum foil.

    For 1,2, 3, 4, 5 contour squares with instructions for use in cardboard pack.
    Storage conditions:

    In a dry, dark place at a temperature of 8 to 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    3 years.

    Do not use the drug after the expiration date.

    Terms of leave from pharmacies:On prescription
    Registration number:P N003294 / 01
    Date of registration:04.04.2011 / 06.02.2014
    Expiration Date:Unlimited
    The owner of the registration certificate:Pacific Institute of Bioorganic Chemistry FEB RAS Pacific Institute of Bioorganic Chemistry FEB RAS Russia
    Manufacturer: & nbsp
    Information update date: & nbsp30.03.2018
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